- The Therapeutic Potential of Sigma (sigma) Receptors for the Treatment of Central Nervous System Diseases: Evaluation of the Evidence
[作者:Banister, SD; Kassiou, M,期刊:Current Pharmaceutical Design, 页码:884-901 , 文章类型: Review,,卷期:2012年18-7]
- Since their proposal in 1976, sigma (sigma) receptors have been increasingly implicated in the pathophysiology of virtually all major central nervous system (CNS) disorders, including anxiety, depression, schizophrenia, ...
- The Ligand Binding Region of the Sigma-1 Receptor: Studies Utilizing Photoaffinity Probes, Sphingosine and N-Alkylamines
[作者:Ruoho, AE; Chu, UB; Ramachandran, S; Fontanilla, D; Mavlyutov, T; Hajipour, AR,期刊:Current Pharmaceutical Design, 页码:920-929 , 文章类型: Review,,卷期:2012年18-7]
- The sigma-1 receptor is a 26 kDa endoplasmic reticulum resident membrane protein that has been shown to have chaperone activity in addition to its promiscuous binding to pharmacological agents. Ligand binding domain(s) o...
- Combinations of Renin-Angiotensin-Aldosterone System Antagonists: True Advantages?
[作者:Veglio, F; Puglisi, E; Milan, A; Mulatero, P,期刊:Current Pharmaceutical Design, 页码:952-957 , 文章类型: Review,,卷期:2012年18-7]
- The renin angiotensin aldosterone system (RAAS) inhibitors induce an incomplete blockade of the system at different steps. Recently, the dual RAAS therapy is emerging in clinical practice, although there is a lack of evi...
- Role of Renin-Angiotensin System in Inflammation, Immunity and Aging
[作者:Capettini, LSA; Montecucco, F; Mach, F; Stergiopulos, N; Santos, RAS; da Silva, RF,期刊:Current Pharmaceutical Design, 页码:963-970 , 文章类型: Review,,卷期:2012年18-7]
- Recent data support the idea that the effects of RAS are not restricted to the cardiovascular and renal systems. Importantly, RAS modulates free radical production and the cellular synthesis of several molecules such as ...
- RAAS Inhibition and Renal Protection
[作者:Giovanna, L; Francesca, V; Roberto, P,期刊:Current Pharmaceutical Design, 页码:971-980 , 文章类型: Review,,卷期:2012年18-7]
- Chronic kidney disease has become a major public health problem worldwide mainly as a consequence of the emerging epidemic of hypertension, diabetes, and obesity. It is currently estimated that nearly 15% of the general ...
- Role of the Renin-Angiotensin-Aldosterone System in the Pathogenesis of Atherosclerosis
[作者:Durante, A; Peretto, G; Laricchia, A; Ancona, F; Spartera, M; Mangieri, A; Cianflone, D,期刊:Current Pharmaceutical Design, 页码:981-1004 , 文章类型: Review,,卷期:2012年18-7]
- Renin-Angiotensin-Aldosterone (RAAS) is a hormone system which acts on multiple physiologic pathways primarily by regulating blood pressure and fluid balance, but also by local autocrine and paracrine actions. In pathoph...
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