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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共21条记录   Flexible fitting of atomic structures into electron microscopy maps using molecular dynamics [作者：Trabuco, LG; Villa, E; Mitra, K; Frank, J; Schulten, K,期刊：Structure, 页码：673-683 , 文章类型： Article，,卷期：2008年16-5] A novel method to flexibly fit atomic structures into electron microscopy (EM) maps using molecular dynamics simulations is presented. The simulations incorporate the EM data as an external potential added to the molecul... A coupled equilibrium shift mechanism in calmodulin-mediated signal transduction [作者：Gsponer, J; Christodoulou, J; Cavalli, A; Bui, JM; Richter, B; Dobson, CM; Vendruscolo, M,期刊：Structure, 页码：736-746 , 文章类型： Article，,卷期：2008年16-5] We used nuclear magnetic resonance data to determine ensembles of conformations representing the structure and dynamics of calmodulin (CaM) in the calcium-bound state (Ca2+-CaM)and in the state bound to myosin light c... The molecular mechanism of toxin-induced conformational changes in a potassium channel: Relation to C-type inactivation [作者：Zachariae, U; Schneider, R; Velisetty, P; Lange, A; Seeliger, D; Wacker, SJ; Karimi-Nejad, Y; Vriend, G; Becker, S; Pongs, O; Baldus, M; de Groot, BL,期刊：Structure, 页码：747-754 , 文章类型： Article，,卷期：2008年16-5] Recently, a solid-state NMR study revealed that scorpion toxin binding leads to conformational changes in the selectivity filter of potassium channels. The exact nature of the conformational changes, however, remained el... Multiple conformations of E-coli Hsp90 in solution: Insights into the conformational dynamics of Hsp90 [作者：Krukenberg, KA; Forster, F; Rice, LM; Sali, A; Agard, DA,期刊：Structure, 页码：755-765 , 文章类型： Article，,卷期：2008年16-5] Hsp90, an essential eukaryotic chaperone, depends upon its intrinsic ATPase activity for function. Crystal structures of the bacterial Hsp90 homolog, HtpG, and the yeast Hsp90 reveal large domain rearrangements between t... An intersubunit active site between supercoiled parallel beta helices in the trimeric tailspike endorhamnosidase of Shigella flexneri phage Sf6 [作者：Muller, JJ; Barbirz, S; Heinle, K; Freiberg, A; Seckler, R; Heinemann, U,期刊：Structure, 页码：766-775 , 文章类型： Article，,卷期：2008年16-5] Sf6 belongs to the Podoviridae family of temperate bacteriophages that infect gram-negative bacteria by insertion of their double-stranded DNA. They attach to their hosts specifically via their tailspike proteins. The 1.... Partitivirus structure reveals a 120-subunit, helix-rich capsid with distinctive surface arches formed by quasisymmetric coat-protein dimers [作者：Ochoa, WF; Havens, WM; Sinkovits, RS; Nibert, ML; Ghabrial, SA; Baker, TS,期刊：Structure, 页码：776-786 , 文章类型： Article，,卷期：2008年16-5] Two distinct partitiviruses, Penicillium stoloniferurn viruses S and F, can be isolated from the fungus Penicillium stoloniferum. The bisegmented dsRNA genomes of these viruses are separately packaged in icosahedral caps... Crystal structure of NFAT bound to the HIV-1 LTR tandem kappa B enhancer element [作者：Bates, DL; Barthel, KKB; Wu, YQ; Kalhor, R; Stroud, JC; Giffin, MJ; Chen, L,期刊：Structure, 页码：684-694 , 文章类型： Article，,卷期：2008年16-5] The host factor, nuclear factor of activated T-cells (NFAT), regulates the transcription and replication of HIV-1. Here, we have determined the crystal structure of the DNA binding domain of NFAT bound to the HIV-1 long ... X-ray scattering study of activated Arp2/3 complex with bound actin-WCA [作者：Boczkowska, M; Rebowski, G; Petoukhov, MV; Hayes, DB; Svergun, DI; Dominguez, R,期刊：Structure, 页码：695-704 , 文章类型： Article，,卷期：2008年16-5] Previous structures of Arp2/3 complex, determined in the absence of a nucleation-promoting factor and actin, reveal its inactive conformation. The study of the activated structure has been hampered by uncontrollable poly... The leucine-rich repeat domain of internalin B folds along a polarized N-terminal pathway [作者：Courtemanche, N; Barrick, D,期刊：Structure, 页码：705-714 , 文章类型： Article，,卷期：2008年16-5] The leucine-rich repeat domain of Internalin B is composed of seven tandem leucine-rich repeats, which each contain a short beta strand connected to a 3(10) helix by a short turn, and an N-terminal alpha-helical capping ... Improved structures of full-length p97, an AAA ATPase: Implications for mechanisms of nucleotide-dependent conformational change [作者：Davies, JM; Brunger, AT; Weis, WI,期刊：Structure, 页码：715-726 , 文章类型： Article，,卷期：2008年16-5] The ATPases associated with various cellular activities (AAA) protein p97 has been implicated in a variety of cellular processes, including endoplasmic reticulum-associated degradation and homotypic membrane fusion. p97 ... Structure of the Staphylococcus aureus AgrA LytTR domain bound to DNA reveals a beta fold with an unusual mode of binding [作者：Sidote, DJ; Barbieri, CM; Wu, T; Stock, AM,期刊：Structure, 页码：727-735 , 文章类型： Article，,卷期：2008年16-5] The LytTR domain is a DNA-binding motif found within the AlgR/AgrA/LytR family of transcription factors that regulate virulence factor and toxin gene expression in pathogenic bacteria. This previously uncharacterized dom... Transmembrane helix uniformity examined by spectral mapping of torsion angles [作者：Page, RC; Kim, S; Cross, TA,期刊：Structure, 页码：787-797 , 文章类型： Article，,卷期：2008年16-5] The environment and unique balance of molecular forces within lipid bilayers has a profound impact upon the structure, dynamics, and function of membrane proteins. We describe the biophysical foundations for the remarkab... Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site [作者：Rushe, M; Silvian, L; Bixler, S; Chen, LL; Cheung, A; Bowes, S; Cuervo, H; Berkowitz, S; Zheng, T; Guckian, K; Pellegrini, M; Lugovskoy, A,期刊：Structure, 页码：798-808 , 文章类型： Article，,卷期：2008年16-5] The phosphorylation Of I kappa B by the IKK complex targets it for degradation and releases NF-kappa B for translocation into the nucleus to initiate the inflammatory response, cell proliferation, or cell differentiation... Crystal structures of human saposins C and D: Implications for lipid recognition and membrane interactions [作者：Rossmann, M; Schultz-Heienbrok, R; Behlke, J; Remmel, N; Alings, C; Sandhoff, K; Saenger, W; Maier, T,期刊：Structure, 页码：809-817 , 文章类型： Article，,卷期：2008年16-5] Human saposins are essential proteins required for degradation of sphingolipids and lipid antigen presentation. Despite the conserved structural organization of saposins, their distinct modes of interaction with biologic... Structural plasticity underpins promiscuous binding of the prosurvival protein a1 [作者：Smits, C; Czabotar, PE; Hinds, MG; Day, CL,期刊：Structure, 页码：818-829 , 文章类型： Article，,卷期：2008年16-5] Apoptotic pathways are regulated by protein-protein interactions. Interaction of the BH3 domains of proapoptotic Bcl-2 family proteins with the hydrophobic groove of prosurvival proteins is critical. Whereas some BH3 dom... Assembly of a tightly interwound DNA recombination complex poised for deletion [作者：Johnson, RC; Heiss, JK,期刊：Structure, 页码：653-655 , 文章类型： Editorial Material，,卷期：2008年16-5] In a recent issue of Molecular Cell, Mouw et al. (2008) report a crystal structure of a serine recombinase bound to a regulatory DNA site in an unexpected synaptic complex configuration, which forms the framework for a n...