- Structures of Ca(V)2Ca(2+)/CaM-IQ Domain Complexes Reveal Binding Modes that Underlie Calcium-Dependent Inactivation and Facilitation
[作者：Kim, EY; Rumpf, CH; Fujiwara, Y; Cooley, ES; Van Petegem, F; Minor, DL,期刊：Structure, 页码：1455-1467 , 文章类型： Article，,卷期：2008年16-10]
- Calcium influx drives two opposing voltage-activated calcium channel (Ca-V) self-modulatory processes: calcium-dependent inactivation (CDI) and calcium-dependent facilitation (CDF). Specific Ca2+/calmodulin (Ca2+/CaM) lo...
- Elucidation of Rab27 Recruitment by Its Effectors: Structure of Rab27a Bound to Exophilin4/Slp2-a
[作者：Chavas, LMG; Ihara, K; Kawasaki, M; Torii, S; Uejima, T; Kato, R; Izumi, T; Wakatsuki, S,期刊：Structure, 页码：1468-1477 , 文章类型： Article，,卷期：2008年16-10]
- Rab GTPases coordinate vesicular trafficking within eukaryotic cells by collaborating with a set of effector proteins. Rab27a regulates numerous exocytotic pathways, and its dysfunction causes the Griscelli syndrome huma...
- Structural Basis for the Exclusive Specificity of Slac2-a/Melanophilin for the Rab27 GTPases
[作者：Kukimoto-Niino, M; Sakamoto, A; Kanno, E; Hanawa-Suetsugu, K; Terada, T; Shirouzu, M; Fukuda, M; Yokoyama, S,期刊：Structure, 页码：1478-1490 , 文章类型： Article，,卷期：2008年16-10]
- Rab27A is required for actin-based melanosome transport in mammalian skin melanocytes through its interaction with a specific effector, Slac2-a/melanophilin. Mutations that disrupt the Rab27A/Slac2-a interaction cause hu...
- Virus Capsid Expansion Driven by the Capture of Mobile Surface Loops
[作者：Lee, KK; Gan, L; Tsuruta, H; Moyer, C; Conway, JF; Duda, RL; Hendrix, RW; Steven, AC; Johnson, JE,期刊：Structure, 页码：1491-1502 , 文章类型： Article，,卷期：2008年16-10]
- The capsids of tailed-DNA bacteriophages first assemble as procapsids, which mature by converting into a new form that is strong enough to contain a densely packed viral chromosome. We demonstrate that the intersubunit c...
- Architecture of the Pontin/Reptin Complex, Essential in the Assembly of Several Macromolecular Complexes
[作者：Torreira, E; Jha, S; Lopez-Blanco, JR; Arias-Palomo, E; Chacon, P; Canas, C; Ayora, S; Dutta, A; Llorca, O,期刊：Structure, 页码：1511-1520 , 文章类型： Article，,卷期：2008年16-10]
- Pontin and reptin belong to the AAA+ family, and they are essential for the structural integrity and catalytic activity of several chromatin remodeling complexes. They are also indispensable for the assembly of several r...
- Structural Analysis of the Interactions Between Paxillin LD Motifs and alpha-Parvin
[作者：Lorenz, S; Vakonakis, I; Lowe, ED; Campbell, LD; Noble, MEM; Hoellerer, MK,期刊：Structure, 页码：1521-1531 , 文章类型： Article，,卷期：2008年16-10]
- The adaptor protein paxillin contains five conserved leucine-rich (LD) motifs that interact with a variety of focal adhesion proteins, such as alpha-parvin. Here, we report the first crystal structure of the C-terminal c...
- Recognition of the Activated States of G alpha 13 by the rgRGS Domain of PDZRhoGEF
[作者：Chen, Z; Singer, WD; Danesh, SM; Sternweis, PC; Sprang, SR,期刊：Structure, 页码：1532-1543 , 文章类型： Article，,卷期：2008年16-10]
- G12 class heterotrimeric G proteins stimulate RhoA activation by RGS-RhoGEFs. However, p115RhoGEF is a GTPase Activating Protein (GAP) toward Gal 3, whereas PDZRhoGEF is not. We have characterized the interaction between...
- Structural Characterization of the Type-III Pilot-Secretin Complex from Shigella flexneri
[作者：Okon, M; Moraes, TF; Lario, PI; Creagh, AL; Haynes, CA; Strynadka, NCJ; Mclntosh, LP,期刊：Structure, 页码：1544-1554 , 文章类型： Article，,卷期：2008年16-10]
- Assembly of the type-III secretion apparatus, which translocates proteins through both membranes of Gram-negative bacterial pathogens into host cells, requires the formation of an integral outer-membrane secretin ring. T...
- Structure of Seneca Valley Virus-001: An Oncolytic Picornavirus Representing a New Genus
[作者：Venkataraman, S; Reddy, SP; Loo, J; Idamakanti, N; Hallenbeck, PL; Reddy, VS,期刊：Structure, 页码：1555-1561 , 文章类型： Article，,卷期：2008年16-10]
- The crystal structure of Seneca Valley Virus-001 (SVV-001), the representative member of a new genus, Senecavirus, is reported at 2.3 angstrom resolution. SVV-001 is the first naturally occurring nonpathogenic picornavir...
- Structural Basis for Ca2+-Dependent Formation of ALG-2/Alix Peptide Complex: Ca2+/EF3-Driven Arginine Switch Mechanism
[作者：Suzuki, H; Kawasaki, M; Inuzuka, T; Okumura, M; Kakiuchi, T; Shibata, H; Wakatsuki, S; Maki, M,期刊：Structure, 页码：1562-1573 , 文章类型： Article，,卷期：2008年16-10]
- ALG-2 belongs to the penta-EF-hand (PEF)protein family and interacts with various intracellular proteins, such as Alix and TSG101, that are involved in endosomal sorting and HIV budding. Through X-ray crystallography, we...
- Structure and Plasticity of Endophilin and Sorting Nexin 9
[作者：Wang, Q; Kaan, HYK; Hooda, RN; Goh, SL; Sondermann, H,期刊：Structure, 页码：1574-1587 , 文章类型： Article，,卷期：2008年16-10]
- Endophilin and Sorting Nexin 9 (Snx9) play key roles in endocytosis by membrane curvature sensing and remodeling via their Bin/Amphiphysin/Rvs (BAR) domains. BAR and the related F-BAR domains form dimeric, crescent-shape...
- A Potent Peptidomimetic Inhibitor of Botulinum Neurotoxin Serotype A Has a Very Different Conformation than SNAP-25 Substrate
[作者：Zuniga, JE; Schmidt, JJ; Fenn, T; Burnett, JC; Arac, D; Gussio, R; Stafford, RG; Badie, SS; Bavari, S; Brunger, AT,期刊：Structure, 页码：1588-1597 , 文章类型： Article，,卷期：2008年16-10]
- Botulinum neurotoxin serotype A is the most lethal of all known toxins. Here, we report the crystal structure, along with SAR data, of the zinc metalloprotease domain of BoNT/A bound to a potent peptidomimetic inhibitor ...
- Key Determinants of Rab Specificity
[作者：Itzen, A; Goody, RS,期刊：Structure, 页码：1437-1439 , 文章类型： Editorial Material，,卷期：2008年16-10]
- Structures are reported for complexes between Rab27 and the Rab27-binding domains of two molecules involved in successive steps in melanosome transport. Comparison of the Rab27B:Slac2-a (Chavas et al., 2008) and Rab27A:S...
- Tripping a Switch: PDZRhoGEF rgRGS-Bound G alpha 13
[作者：Hamaneh, MB; Buck, M,期刊：Structure, 页码：1439-1441 , 文章类型： Editorial Material，,卷期：2008年16-10]
- Ras superfamily guanine nucleotide-binding proteins, such as G-proteins and small GTPases, are a paradigm for two-state molecular switches in cell signaling. Recent experimental and theoretical studies question this simp...
- A Pilot Sheds Light on Secretin Assembly
[作者：Derrick, J,期刊：Structure, 页码：1441-1442 , 文章类型： Editorial Material，,卷期：2008年16-10]
- The structure of a pilot protein (MxiM), in complex with a peptide from its cognate secretin (MxiD), reported by Okon et al. (2008), shows how specific recognition between the two proteins is achieved and suggests a mode...
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