- JAK2 inhibition for the treatment of hematologic and solid malignancies
[作者:Harry, BL; Eckhardt, SG; Jimeno, A,期刊:Expert opinion on investigational drugs, 页码:637-655 , 文章类型: Review,,卷期:2012年21-5]
- Introduction: Mutations in Janus kinase 2 (JAK2), and in particular JAK2 V617F, are common in Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). In the past several years, JAK2 inhibitors have been rap...
- Targeting of polo-like kinases and their cross talk with Aurora kinases - possible therapeutic strategies in human acute myeloid leukemia?
[作者:Tsykunova, G; Reikvam, H; Ahmed, AB; Nepstad, I; Gjertsen, BT; Bruserud, O,期刊:Expert opinion on investigational drugs, 页码:587-603 , 文章类型: Review,,卷期:2012年21-5]
- Introduction: Five human polo-like kinases (PLKs) have been identified, and PLK1 - 4 seem to interact with Aurora kinases and act as cell cycle regulators in both normal and malignant human cells.Areas covered: The prese...
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