- Drug Design and Identification of Potent Leads Against Mycobacterium tuberculosis Thymidine Monophosphate Kinase
[作者:Van Calenbergh, S; Pochet, S; Munier-Lehmann, H,期刊:Current Topics in Medicinal Chemistry, 页码:694-705 , 文章类型: Review,,卷期:2012年12-7]
- Antiviral chemotherapy often relies on nucleoside analogues, which, once phophorylated by intracellular kinases, target viral polymerases impeding DNA synthesis. In contrast, nucleoside analogues are much less explored a...
- Derivatives of 3-Isoxazolecarboxylic Acid Esters - A Potent and Selective Compound Class against Replicating and Nonreplicating Mycobacterium tuberculosis
[作者:Lilienkampf, A; Pieroni, M; Franzblau, SG; Bishai, WR; Kozikowski, AP,期刊:Current Topics in Medicinal Chemistry, 页码:729-734 , 文章类型: Review,,卷期:2012年12-7]
- New antituberculosis (anti-TB) drugs are urgently needed to battle drug-resistant Mycobacterium tuberculosis (Mtb) strains and to shorten the long treatment regimen. A series of isoxazole-based compounds, bearing a carbo...
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