- Delta 6-desaturase (FADS2) deficiency unveils the role of omega 3- and omega 6-polyunsaturated fatty acids
[作者:Stoffel, W; Holz, B; Jenke, B; Binczek, E; Gunter, RH; Kiss, C; Karakesisoglou, I; Thevis, M; Weber, AA; Arnhold, S; Addicks, K,期刊:EMBO journal, 页码:2281-2292 , 文章类型: Article,,卷期:2008年27-17]
- Mammalian cell viability is dependent on the supply of the essential fatty acids (EFAs) linoleic and alpha-linolenic acid. EFAs are converted into omega 3- and omega 6-polyunsaturated fatty acids (PUFAs), which are essen...
- Dopamine D2 receptors form higher order oligomers at physiological expression levels
[作者:Guo, W; Urizar, E; Kralikova, M; Mobarec, JC; Shi, L; Filizola, M; Javitch, JA,期刊:EMBO journal, 页码:2293-2304 , 文章类型: Article,,卷期:2008年27-17]
- G-protein-coupled receptors are generally thought to be organized as dimers; whether they form higher order oligomers is a topic of much controversy. We combined bioluminescence/fluorescence complementation and energy tr...
- Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein
[作者:Brummer, T; Larance, M; Abreu, MTH; Lyons, RJ; Timpson, P; Emmerich, CH; Fleuren, EDG; Lehrbach, GM; Schramek, D; Guilhaus, M; James, DE; Daly, RJ,期刊:EMBO journal, 页码:2305-2316 , 文章类型: Article,,卷期:2008年27-17]
- Grb2-associated binder ( Gab) 2 functions downstream of a variety of receptor and cytoplasmic tyrosine kinases as a docking platform for specific signal transducers and performs important functions in both normal physiol...
- The plant-specific TFIIB-related protein, pBrp, is a general transcription factor for RNA polymerase I
[作者:Imamura, S; Hanaoka, M; Tanaka, K,期刊:EMBO journal, 页码:2317-2327 , 文章类型: Article,,卷期:2008年27-17]
- TFIIB and BRF are general transcription factors (GTFs) for eukaryotic RNA polymerases II and III, respectively, and have important functions in transcriptional initiation. In this study, the third type of TFIIB-related p...
- Distinct roles for yeast Stn1 in telomere capping and telomerase inhibition
[作者:Puglisi, A; Bianchi, A; Lemmens, L; Damay, P; Shore, D,期刊:EMBO journal, 页码:2328-2339 , 文章类型: Article,,卷期:2008年27-17]
- The budding yeast Cdc13, Stn1 and Ten1 (CST) proteins are proposed to function as an RPA-like complex at telomeres that protects ('caps') chromosome ends and regulates their elongation by telomerase. We show that Stn1 ha...
- Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex
[作者:Hecker, A; Lopreiato, R; Graille, M; Collinet, B; Forterre, P; Libri, D; van Tilbeurgh, H,期刊:EMBO journal, 页码:2340-2351 , 文章类型: Article,,卷期:2008年27-17]
- The EKC/KEOPS yeast complex is involved in telomere maintenance and transcription. The Bud32p and kinase-associated endopeptidase 1 (Kae1p) components of the complex are totally conserved in eukarya and archaea. Their ge...
- Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase (vol 27, pg 2239, 2008)
[作者:Gotthardt, K; Weyand, M; Kortholt, A; Van Haastert, PJM; Wittinghofer, A,期刊:EMBO journal, 页码:2352-2352 , 文章类型: Correction,,卷期:2008年27-17]
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- Architectures and biogenesis of non-flagellar protein appendages in Gram-negative bacteria
[作者:Fronzes, R; Remaut, H; Waksman, G,期刊:EMBO journal, 页码:2271-2280 , 文章类型: Review,,卷期:2008年27-17]
- Bacteria commonly expose non-flagellar proteinaceous appendages on their outer surfaces. These extracellular structures, called pili or fimbriae, are employed in attachment and invasion, biofilm formation, cell motility ...
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