- Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively
[作者：Pebernard, S; Schaffer, L; Campbell, D; Head, SR; Boddy, MN,期刊：EMBO journal, 页码：3011-3023 , 文章类型： Article，,卷期：2008年27-22]
- The Smc5/6 holocomplex executes key functions in genome maintenance that include ensuring the faithful segregation of chromosomes at mitosis and facilitating critical DNA repair pathways. Smc5/6 is essential for viabilit...
- RNA-dependent recruitment of the origin recognition complex
[作者：Norseen, J; Thomae, A; Sridharan, V; Aiyar, A; Schepers, A; Lieberman, PM,期刊：EMBO journal, 页码：3024-3035 , 文章类型： Article，,卷期：2008年27-22]
- The origin recognition complex (ORC) has an important function in determining the initiation sites of DNA replication. In higher eukaryotes, ORC lacks sequence-specific DNA binding, and the mechanisms of ORC recruitment ...
- Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe
[作者：Nakamura, KI; Okamoto, A; Katou, Y; Yadani, C; Shitanda, T; Kaweeteerawat, C; Takahashi, TS; Itoh, T; Shirahige, K; Masukata, H; Nakagawa, T,期刊：EMBO journal, 页码：3036-3046 , 文章类型： Article，,卷期：2008年27-22]
- Centromere that plays a pivotal role in chromosome segregation is composed of repetitive elements in many eukaryotes. Although chromosomal regions containing repeats are the hotspots of rearrangements, little is known ab...
- ASIC3, a sensor of acidic and primary inflammatory pain
[作者：Deval, E; Noel, J; Lay, N; Alloui, A; Diochot, S; Friend, V; Jodar, M; Lazdunski, M; Lingueglia, E,期刊：EMBO journal, 页码：3047-3055 , 文章类型： Article，,卷期：2008年27-22]
- Acid-sensing ion channels (ASICs) are cationic channels activated by extracellular acidosis that are expressed in both central and peripheral nervous systems. Although peripheral ASICs seem to be natural sensors of acidi...
- Thrombospondin-1 binds to ApoER2 and VLDL receptor and functions in postnatal neuronal migration
[作者：Blake, SM; Strasser, V; Andrade, N; Duit, S; Hofbauer, R; Schneider, WJ; Nimpf, J,期刊：EMBO journal, 页码：3069-3080 , 文章类型： Article，,卷期：2008年27-22]
- Apolipoprotein E receptor 2 (ApoER2), very low-density lipoprotein receptor (VLDLR), and Dab1 are the main components of the Reelin signalling cascade. Reelin is the sole ligand defined so far in signalling through this ...
- Clustering of VASP actively drives processive, WH2 domain-mediated actin filament elongation
[作者：Breitsprecher, D; Kiesewetter, AK; Linkner, J; Urbanke, C; Resch, GP; Small, JV; Faix, J,期刊：EMBO journal, 页码：2943-2954 , 文章类型： Article，,卷期：2008年27-22]
- Vasodilator-stimulated phosphoprotein (VASP) is a key regulator of dynamic actin structures like filopodia and lamellipodia, but its precise function in their formation is controversial. Using in vitro TIRF microscopy, w...
- An Id-like molecule, HHM, is a synexpression group-restricted regulator of TGF-beta signalling
[作者：Ikushima, H; Komuro, A; Isogaya, K; Shinozaki, M; Hellman, U; Miyazawa, K; Miyazono, K,期刊：EMBO journal, 页码：2955-2965 , 文章类型： Article，,卷期：2008年27-22]
- Transforming growth factor (TGF)-beta induces various cellular responses principally through Smad-dependent transcriptional regulation. Activated Smad complexes cooperate with transcription factors in regulating a group ...
- A novel disulphide switch mechanism in Ero1 alpha balances ER oxidation in human cells
[作者：Appenzeller-Herzog, C; Riemer, J; Christensen, B; Sorensen, ES; Ellgaard, L,期刊：EMBO journal, 页码：2977-2987 , 文章类型： Article，,卷期：2008年27-22]
- Oxidative maturation of secretory and membrane proteins in the endoplasmic reticulum (ER) is powered by Ero1 oxidases. To prevent cellular hyperoxidation, Ero1 activity can be regulated by intramolecular disulphide switc...
- Low reduction potential of Ero1 alpha regulatory disulphides ensures tight control of substrate oxidation
[作者：Baker, KM; Chakravarthi, S; Langton, KP; Sheppard, AM; Lu, H; Bulleid, NJ,期刊：EMBO journal, 页码：2988-2997 , 文章类型： Article，,卷期：2008年27-22]
- Formation of disulphide bonds within the mammalian endoplasmic reticulum (ER) requires the combined activities of Ero1 alpha and protein disulphide isomerase (PDI). As Ero1 alpha produces hydrogen peroxide during oxidati...
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