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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   New 26S Proteasome Inhibitors with High Selectivity for Chymotrypsin-Like Activity and p53-Dependent Cytotoxicity [作者：NEILSEN PAUL M; PEHERE ASHOK D; PISHAS KATHLEEN I; CALLEN DAVID F; ABELL ANDREW D,期刊：ACS CHEMICAL BIOLOGY, 页码：353-359 , 文章类型： Article，,卷期：2013年8-2] The 26S proteasome has emerged over the past decade as an attractive therapeutic target in the treatment of cancers. Here, we report new tripeptide aldehydes that are highly specific for the chymotrypsin-like catalytic a... Role of SbmA in the Uptake of Peptide Nucleic Acid (PNA)-Peptide Conjugates in E-coli [作者：GHOSAL ANUBRATA; VITALI ALLY; STACH JAMES E M; NIELSEN PETER E,期刊：ACS CHEMICAL BIOLOGY, 页码：360-367 , 文章类型： Article，,卷期：2013年8-2] Antisense PNA oligomers targeting essential genes (acpP or ftsZ) and conjugated to the delivery peptide L((KFF)(3)K) show complete growth inhibition of wild type E. coil strain (MG1655) with submicromolar MIC. In this st... Effective Phagocytosis of Low Her2 Tumor Cell Lines with Engineered, Aglycosylated IgG Displaying High Fc gamma RIIa Affinity and Selectivity [作者：JUNG SANG TAEK; KELTON WILLIAM; KANG TAE HYUN; NG DAPHNE T W; ANDERSEN JAN TERJE; SANDLIE INGER; SARKAR CASIM A; GEORGIOU GEORGE,期刊：ACS CHEMICAL BIOLOGY, 页码：368-375 , 文章类型： Article，,卷期：2013年8-2] Glycans anchored to residue N297 of the antibody IgG Fc domain are critical in mediating binding toward Fc gamma Rs to direct both adaptive and innate immune responses. However, using a full length bacterial IgG display ... Engineering the Binding Site of an Antibody against N-Glycolyl GM3: From Functional Mapping to Novel Anti-ganglioside Specificities [作者：ROJAS GERTRUDIS; PUPO AMAURY; GOMEZ SILVIA; KRENGEL UTE; MORENO ERNESTO,期刊：ACS CHEMICAL BIOLOGY, 页码：376-386 , 文章类型： Article，,卷期：2013年8-2] The structurally related gangliosides N-glycolyl GM3 and N-acetyl GM3 are potential targets for tumor immunotherapy. 14F7 is a monoclonal antibody able to discriminate the tumor-specific antigen N-glycolyl GM3 from the c... Allosteric Competitive Inhibitors of the Glucose-1-phosphate Thymidylyltransferase (RmlA) from Pseudomonas aeruginosa [作者：ALPHEY MAGNUS S; PIRRIE LISA; TORRIE LEAH S; BOULKEROUA WASSILA ABDELLI; GARDINER MARY; SARKAR AURIJIT; MARINGER MARKO; OEHLMANN WULF; BRENK RUTH; SCHERMAN MICHAEL S; MCNEIL MICHAEL; REJZEK MARTIN; FIELD ROBERT A; SINGH MAHAVIR; GRAY DAVID; WESTWOOD NICHOLAS J; NAISMITH JAMES H,期刊：ACS CHEMICAL BIOLOGY, 页码：387-396 , 文章类型： Article，,卷期：2013年8-2] Glucose-1-phosphate thymidylyltransferase (RmlA) catalyzes the condensation of glucose-1-phosphate (G1P) with deoxy-thymidine triphosphate (dTTP) to yield dTDP-D-glucose and pyrophosphate. This is the first step in the L... Rational Epitope Design for Protein Targeting [作者：PERI CLAUDIO; GAGNI PAOLA; COMBI FABIO; GORI ALESSANDRO; CHIARI MARCELLA; LONGHI RENATO; CRETICH MARINA; COLOMBO GIORGIO,期刊：ACS CHEMICAL BIOLOGY, 页码：397-404 , 文章类型： Article，,卷期：2013年8-2] We present a new multidisciplinary strategy integrating computational biology with high-throughput microarray analysis aimed to translate molecular understanding of protein-antibody recognition into the design of efficie... Genetic Incorporation of Twelve meta-Substituted Phenylalanine Derivatives Using a Single Pyrrolysyl-tRNA Synthetase Mutant [作者：WANG YANESHIH; FANG XINQIANG; CHEN HSUEHYING; WU BO; WANG ZHIYONG U; HILTY CHRISTIAN; LIU WENSHE R,期刊：ACS CHEMICAL BIOLOGY, 页码：405-415 , 文章类型： Article，,卷期：2013年8-2] When coexpressed with its cognate amber suppressing tRNA(CUA)(Pyl), a pyrrolysyl-tRNA synthetase mutant N346A/C348A is able to genetically incorporate 12 meta-substituted phenylalanine derivatives into proteins site-spec... Protein-Associated Cation Clusters in Aqueous Arginine Solutions and Their Effects on Protein Stability and Size [作者：VAGENENDE VINCENT; HAN ALVIN X; MUELLER MONIKA; TROUT BERNHARDT L,期刊：ACS CHEMICAL BIOLOGY, 页码：416-422 , 文章类型： Article，,卷期：2013年8-2] Arginine is one of the most prominent residues in protein interactions, and arginine hydrochloride is widely used as an additive in protein solutions because of its exceptional effects on protein association and folding.... Efficient Delivery of Cyclic Peptides into Mammalian Cells with Short Sequence Motifs [作者：QIAN ZIQING; LIU TAO; LIU YUYU; BRIESEWITZ ROGER; BARRIOS AMY M; JHIANG SISSY M; PEI DEHUA,期刊：ACS CHEMICAL BIOLOGY, 页码：423-431 , 文章类型： Article，,卷期：2013年8-2] Cyclic peptides hold great potential as therapeutic agents and research tools, but their broad application has been limited by poor membrane permeability. Here, we report a potentially general approach for intracellular ... HGF Stimulation of Rac1 Signaling Enhances Pharmacological Correction of the Most Prevalent Cystic Fibrosis Mutant F508del-CFTR [作者：MONIZ SONIA; SOUSA MARISA; MORAES BRUNO JOSE; MENDES ANA ISABEL; PALMA MARTA; BARRETO CELESTE; FRAGATA JOSE I; AMARAL MARGARIDA D; MATOS PAULO,期刊：ACS CHEMICAL BIOLOGY, 页码：432-442 , 文章类型： Article，,卷期：2013年8-2] Cystic fibrosis (CF), a major life-limiting genetic disease leading to severe respiratory symptoms, is caused by mutations in CF transmembrane conductance regulator (CFTR), a chloride (Cl-) channel expressed at the apica... Enzyme-Directed Mutasynthesis: A Combined Experimental and Theoretical Approach to Substrate Recognition of a Polyketide Synthase [作者：SUNDERMANN USCHI; BRAVORODRIGUEZ KENNY; KLOPRIES STEPHAN; KUSHNIR SUSANNA; GOMEZ HANSEL; SANCHEZGARCIA ELSA; SCHULZ FRANK,期刊：ACS CHEMICAL BIOLOGY, 页码：443-450 , 文章类型： Article，,卷期：2013年8-2] Acyltransferase domains control the extender unit recognition in Polyketide Synthases (PKS) and thereby the side-chain diversity of the resulting natural products. The enzyme engineering strategy presented here allows th... Kinase Drug Discovery - What's Next in the Field? (vol 8, pg 96, 2012) [作者：COHEN PHILIP; ALESSI DARIO R,期刊：ACS CHEMICAL BIOLOGY, 页码：464-464 , 文章类型： Correction，,卷期：2013年8-2] ATP Sequestration by a Synthetic ATP-Binding Protein Leads to Novel Phenotypic Changes in Escherichia coli [作者：KORCH SHALEEN B; STOMEL JOSHUA M; LEON MEGAN A; HAMADA MATT A; STEVENSON CHRISTINE R; SIMPSON BRENT W; GUJULLA SUNIL K; CHAPUT JOHN C,期刊：ACS CHEMICAL BIOLOGY, 页码：451-463 , 文章类型： Article，,卷期：2013年8-2] Artificial proteins that bind key metabolites with high affinity and specificity hold great promise as new tools in synthetic biology, but little has been done to create such molecules and examine their effects on living... Chemically Modified Tandem Repeats in Proteins: Natural Combinatorial Peptide Libraries [作者：FUCHS STEPHEN M,期刊：ACS CHEMICAL BIOLOGY, 页码：275-282 , 文章类型： Review，,卷期：2013年8-2] Many proteins composed of tandem repeats (a linear motif, directly repeated within the sequence) are substrates for post-translational modifications (PTMs). Tandem repeats are also dynamic in number, presumably due to in... Diverse Functional Roles of Reactive Cysteines [作者：PACE NICHOLAS J; WEERAPANA ERANTHIE,期刊：ACS CHEMICAL BIOLOGY, 页码：283-296 , 文章类型： Review，,卷期：2013年8-2] Cysteine residues on proteins play key roles in catalysis and regulation. These functional cysteines serve as active sites for nucleophilic and redox catalysis, sites of allosteric regulation, and metal-binding ligands o... Stabilizing the Pro-Apoptotic BimBH3 Helix (BimSAHB) Does Not Necessarily Enhance Affinity or Biological Activity [作者：OKAMOTO TORU; ZOBEL KERRY; FEDOROVA ANNA; QUAN CLIFFORD; YANG HONG; FAIRBROTHER WAYNE J; HUANG DAVID C S; SMITH BRIAN J; DESHAYES KURT; CZABOTAR PETER E,期刊：ACS CHEMICAL BIOLOGY, 页码：297-302 , 文章类型： Article，,卷期：2013年8-2] An attractive approach for developing therapeutic peptides is to enhance binding to their targets by stabilizing their a-helical conformation, for example, stabilized BimBH3 peptides (BimSAHB) designed to induce apoptosi...