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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共47条记录   Plasmacytoid dendritic cells lead the charge against tumors [作者：Jimenez-Baranda, S; Silva, IP; Bhardwaj, N,期刊：Journal of clinical investigation, 页码：481-484 , 文章类型： Editorial Material，,卷期：2012年122-2] Imiquimod is a TLR agonist that is used as an antitumor agent, mainly against skin tumors. Its clinical benefits are well described in several studies; however, the mechanisms behind its antitumor effects are not complet... Genetic instability in neural stem cells: an inconvenient truth? [作者：Harrison, NJ,期刊：Journal of clinical investigation, 页码：484-486 , 文章类型： Editorial Material，,卷期：2012年122-2] The evolutionary struggles from which mutants arise have been documented in almost every living system. In this issue of the JCI, Varela and colleagues extend this list of systems to include neural derivatives of human e... Yes, even human brown fat is on fire! [作者：Cannon, B; Nedergaard, J,期刊：Journal of clinical investigation, 页码：486-489 , 文章类型： Editorial Material，,卷期：2012年122-2] That adult humans possess brown fat is now accepted - but is the brown fat metabolically active? Does human brown fat actually combust fat to release heat? In this issue of the JCI, Ouellet et al. demonstrate that metabo... MicroRNAs, fibrotic remodeling, and aortic aneurysms [作者：Milewicz, DM,期刊：Journal of clinical investigation, 页码：490-493 , 文章类型： Editorial Material，,卷期：2012年122-2] Aortic aneurysms are a common clinical condition that can cause death due to aortic dissection or rupture. The association between aortic aneurysm pathogenesis and altered TGF-beta signaling has been the subject of numer... Preserving postischemic reperfusion in the kidney: a role for extracellular adenosine [作者：Weinberg, JM; Venkatachalam, MA,期刊：Journal of clinical investigation, 页码：493-496 , 文章类型： Editorial Material，,卷期：2012年122-2] Several adenosine receptor subtypes on endothelial, epithelial, mesangial, and inflammatory cells have been implicated in ischemic acute kidney injury, a life-threatening condition that frequently complicates the care of... Inhibition of microRNA-29b reduces murine abdominal aortic aneurysm development [作者：Maegdefessel, L; Azuma, J; Toh, R; Merk, DR; Deng, A; Chin, JT; Raaz, U; Schoelmerich, AM; Raiesdana, A; Leeper, NJ; McConnell, MV; Dalman, RL; Spin, JM; Tsao, PS,期刊：Journal of clinical investigation, 页码：497-506 , 文章类型： Article，,卷期：2012年122-2] MicroRNAs (miRs) regulate gene expression at the posttranscriptional level and play crucial roles in vascular integrity. As such, they may have a role in modifying abdominal aortic aneurysm (AAA) expansion, the pathophys... Dopamine dysregulation in a mouse model of paroxysmal nonkinesigenic dyskinesia [作者：Lee, HY; Nakayama, J; Xu, Y; Fan, XL; Karouani, M; Shen, YG; Pothos, EN; Hess, EJ; Fu, YH; Edwards, RH; Ptacek, LJ,期刊：Journal of clinical investigation, 页码：507-518 , 文章类型： Article，,卷期：2012年122-2] Paroxysmal nonkinesigenic dyskinesia (PNKD) is an autosomal dominant episodic movement disorder. Patients have episodes that last 1 to 4 hours and are precipitated by alcohol, coffee, and stress. Previous research has sh... Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver [作者：van de Steeg, E; Stranecky, V; Hartmannova, H; Noskova, L; Hrebicek, M; Wagenaar, E; van Esch, A; de Waart, DR; Elferink, RPJO; Kenworthy, KE; Sticova, E; al-Edreesi, M; Knisely, AS; Kmoch, S; Jirsa, M; Schinkel, AH,期刊：Journal of clinical investigation, 页码：519-528 , 文章类型： Article，,卷期：2012年122-2] Bilirubin, a breakdown product of heme, is normally glucuronidated and excreted by the liver into bile. Failure of this system can lead to a buildup of conjugated bilirubin in the blood, resulting in jaundice. The mechan... IFN-alpha inhibits HBV transcription and replication in cell culture and in humanized mice by targeting the epigenetic regulation of the nuclear cccDNA minichromosome [作者：Belloni, L; Allweiss, L; Guerrieri, F; Pediconi, N; Volz, T; Pollicino, T; Petersen, J; Raimondo, G; Dandri, M; Levrero, M,期刊：Journal of clinical investigation, 页码：529-537 , 文章类型： Article，,卷期：2012年122-2] HBV infection remains a leading cause of death worldwide. IFN-alpha inhibits viral replication in vitro and in vivo, and pegylated IFN-alpha is a commonly administered treatment for individuals infected with HBV. The HBV... Mutations in the ER-shaping protein reticulon 2 cause the axon-degenerative disorder hereditary spastic paraplegia type 12 [作者：Montenegro, G; Rebelo, AP; Connell, J; Allison, R; Babalini, C; D'Aloia, M; Montieri, P; Schule, R; Ishiura, H; Price, J; Strickland, A; Gonzalez, MA; Baumbach-Reardon, L; Deconinck, T; Huang, J; Bernardi, G; Vance, JM; Rogers, MT; Tsuji, S; De Jonghe, P; Pericak-Vance, MA; Schols, L; Orlacchio, A; Reid, E; Zuchner, S,期刊：Journal of clinical investigation, 页码：538-544 , 文章类型： Article，,卷期：2012年122-2] Hereditary spastic paraplegias (HSPs) are a group of genetically heterogeneous neurodegenerative conditions. They are characterized by progressive spastic paralysis of the legs as a result of selective, length-dependent ... Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans [作者：Ouellet, V; Labbe, SM; Blondin, DP; Phoenix, S; Guerin, B; Haman, F; Turcotte, EE; Richard, D; Carpentier, AC,期刊：Journal of clinical investigation, 页码：545-552 , 文章类型： Article，,卷期：2012年122-2] Brown adipose tissue (BAT) is vital for proper thermogenesis during cold exposure in rodents, but until recently its presence in adult humans and its contribution to human metabolism were thought to be minimal or insigni... An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice [作者：Kinross, KM; Montgomery, KG; Kleinschmidt, M; Waring, P; Ivetac, I; Tikoo, A; Saad, M; Hare, L; Roh, V; Mantamadiotis, T; Sheppard, KE; Ryland, GL; Campbell, IG; Gorringe, KL; Christensen, JG; Cullinane, C; Hicks, RJ; Pearson, RB; Johnstone, RW; McArthur, GA; Phillips, WA,期刊：Journal of clinical investigation, 页码：553-557 , 文章类型： Article，,卷期：2012年122-2] Mutations in the gene encoding the p110 alpha subunit of PI3K (PIK3CA) that result in enhanced PI3K activity are frequently observed in human cancers. To better understand the role of mutant PIK3CA in the initiation or p... Monocyte tissue factor-dependent activation of coagulation in hypercholesterolemic mice and monkeys is inhibited by simvastatin [作者：Owens, AP; Passam, FH; Antoniak, S; Marshall, SM; McDaniel, AL; Rudel, L; Williams, JC; Hubbard, BK; Dutton, JA; Wang, JG; Tobias, PS; Curtiss, LK; Daugherty, A; Kirchhofer, D; Luyendyk, JP; Moriarty, PM; Nagarajan, S; Furie, BC; Furie, B; Johns, DG; Temel, RE; Mackman, N,期刊：Journal of clinical investigation, 页码：558-568 , 文章类型： Article，,卷期：2012年122-2] Hypercholesterolemia is a major risk factor for atherosclerosis. It also is associated with platelet hyperactivity, which increases morbidity and mortality from cardiovascular disease. However, the mechanisms by which hy... Recurrent genomic instability of chromosome 1q in neural derivatives of human embryonic stem cells [作者：Varela, C; Denis, JA; Polentes, J; Feyeux, M; Aubert, S; Champon, B; Pietu, G; Peschanski, M; Lefort, N,期刊：Journal of clinical investigation, 页码：569-574 , 文章类型： Article，,卷期：2012年122-2] Human pluripotent stem cells offer a limitless source of cells for regenerative medicine. Neural derivatives of human embryonic stem cells (hESCs) are currently being used for cell therapy in 3 clinical trials. However, ... Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells [作者：Drobits, B; Holcmann, M; Amberg, N; Swiecki, M; Grundtner, R; Hammer, M; Colonna, M; Sibilia, M,期刊：Journal of clinical investigation, 页码：575-585 , 文章类型： Article，,卷期：2012年122-2] Imiquimod is a synthetic compound with antitumor properties; a 5% cream formulation is successfully used to treat skin tumors. The antitumor effect of imiquimod is multifactorial, although its ability to modulate immune ... Oncogenic beta-catenin triggers an inflammatory response that determines the aggressiveness of hepatocellular carcinoma in mice [作者：Anson, M; Crain-Denoyelle, AM; Baud, V; Chereau, F; Gougelet, A; Terris, B; Yamagoe, S; Colnot, S; Viguier, M; Perret, C; Couty, JP,期刊：Journal of clinical investigation, 页码：586-599 , 文章类型： Article，,卷期：2012年122-2] Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Its pathogenesis is frequently linked to liver inflammation. Gain-of-function mutations in the gene encoding beta-catenin are f...