- Post-transfer editing by a eukaryotic leucyl-tRNA synthetase resistant to the broad-spectrum drug AN2690
[作者:Zhou, XL; Tan, M; Wang, M; Chen, X; Wang, ED,期刊:Biochemical Journal, 页码:325-333 , 文章类型: Article,,卷期:2010年430-Part 2]
- Some aaRSs (aminoacyl-tRNA synthetases) develop editing mechanisms to correct mis-charged tRNA. The CP1 (connective peptide 1) domain of LeuRS (leucyl-tRNA synthetase) contains the editing active site, which is the prove...
- Distribution and paralogue specificity of mammalian deSUMOylating enzymes
[作者:Kolli, N; Mikolajczyk, J; Drag, M; Mukhopadhyay, D; Moffatt, N; Dasso, M; Salvesen, G; Wilkinson, KD,期刊:Biochemical Journal, 页码:335-344 , 文章类型: Article,,卷期:2010年430-Part 2]
- The covalent attachment of SUMO (small ubiquitin-like protein modifier) to target proteins results in modifications in their activity, binding interactions, localization or half-life. The reversal of this modification is...
- c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18
[作者:Yeap, YYC; Ng, IHW; Badrian, B; Nguyen, TV; Yip, YY; Dhillon, AS; Mutsaers, SE; Silke, J; Bogoyevitch, MA; Ng, DCH,期刊:Biochemical Journal, 页码:345-354 , 文章类型: Article,,卷期:2010年430-Part 2]
- The JNKs (c-Jun N-terminal kinases) are stress-activated serine/threonine kinases that can regulate both cell death and cell proliferation. We have developed a cell system to control JNK re-expression at physiological le...
- Promiscuous partnering and independent activity of MexB, the multidrug transporter protein from Pseudomonas aeruginosa
[作者:Welch, A; Awah, CU; Jing, SH; van Veen, HW; Venter, H,期刊:Biochemical Journal, 页码:355-364 , 文章类型: Article,,卷期:2010年430-Part 2]
- The MexAB-OprM drug efflux pump is central to multidrug resistance of Pseudomonas aeruginosa. The ability of the tripartite protein to confer drug resistance on the pathogen is crucially dependent on the presence of all ...
- Human RASSF7 regulates the microtubule cytoskeleton and is required for spindle formation, Aurora B activation and chromosomal congression during mitosis
[作者:Recino, A; Sherwood, V; Flaxman, A; Cooper, WN; Latif, F; Ward, A; Chalmers, AD,期刊:Biochemical Journal, 页码:207-213 , 文章类型: Article,,卷期:2010年430-Part 2]
- RASSF7, a member of the N-terminal Ras association domain family, has increased expression in various cancers and, on the basis of our previous work in Xenopus embryos, may be a regulator of mitosis. In the present study...
- Genomic tagging reveals a random association of endogenous PtdIns5P 4-kinases II alpha and II beta and a partial nuclear localization of the II alpha isoform
[作者:Wang, MC; Bond, NJ; Letcher, AJ; Richardson, JP; Lilley, KS; Irvine, RF; Clarke, JH,期刊:Biochemical Journal, 页码:215-221 , 文章类型: Article,,卷期:2010年430-Part 2]
- PtdIns5P 4-kinases II alpha and II beta are cytosolic and nuclear respectively when transfected into cells, including DT40 cells [Richardson, Wang, Clarke, Patel and Irvine (2007) Cell. Signalling 119, 1309-1314]. In the...
- Dual roles for MEF2A and MEF2D during human macrophage terminal differentiation and c-Jun expression
[作者:Aude-Garcia, C; Collin-Faure, V; Bausinger, H; Hanau, D; Rabilloud, T; Lemercier, C,期刊:Biochemical Journal, 页码:237-244 , 文章类型: Article,,卷期:2010年430-Part 2]
- Recent reports have evidenced a role for MEF2C (myocyte enhancer factor 2C) in myelopoiesis, although the precise functions of this transcription factor are still unclear. We show in the present study that MEF2A and MEF2...
- Sterol-regulatory-element-binding protein 1c mediates the effect of insulin on the expression of Cidea in mouse hepatocytes
[作者:Wang, R; Kong, XX; Cui, AF; Liu, XJ; Xiang, RL; Yang, YL; Guan, YF; Fang, FD; Chang, YS,期刊:Biochemical Journal, 页码:245-254 , 文章类型: Article,,卷期:2010年430-Part 2]
- Members of the Cide [cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector] gene family have been reported to be associated with lipid metabolism. In the present study, we show that Cidea mRNA levels ar...
- Role of calpain in the regulation of CFTR (cystic fibrosis transmembrane conductance regulator) turnover
[作者:Averna, M; Stifanese, R; Grosso, R; Pedrazzi, M; De Tullio, R; Salamino, F; Pontremoli, S; Melloni, E,期刊:Biochemical Journal, 页码:255-263 , 文章类型: Article,,卷期:2010年430-Part 2]
- The level of the mature native 170 kDa form of CFTR (cystic fibrosis transmembrane conductance regulator) at the plasma membrane is under the control of a selective proteolysis catalysed by calpain. The product of this l...
- Substrate-specific binding and conformational changes involving Ser(313) and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking
[作者:Hou, ZJ; Wu, JM; Ye, J; Cherian, C; Matherly, LH,期刊:Biochemical Journal, 页码:265-274 , 文章类型: Article,,卷期:2010年430-Part 2]
- RFC (reduced folate carrier) is the major transporter for reduced folates and anti folates [e.g. MIX (methotrexate)]. RFC is characterized by two halves, each with six TMD (transmembrane domain) alpha helices connected b...
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