- The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals
[作者:Thierbach, R; Drewes, G; Fusser, M; Voigt, A; Kuhlow, D; Blume, U; Schulz, TJ; Reiche, C; Glatt, H; Epe, B; Steinberg, P; Ristow, M,期刊:Biochemical Journal, 页码:165-172 , 文章类型: Article,,卷期:2010年432-Part 1]
- DNA-repair mechanisms enable cells to maintain their genetic information by protecting it from mutations that may cause malignant growth. Recent evidence suggests that specific DNA-repair enzymes contain ISCs (iron-sulfu...
- Shiga toxin 1 and ricin A chain bind to human polymorphonuclear leucocytes through a common receptor
[作者:Arfilli, V; Carnicelli, D; Rocchi, L; Ricci, F; Pagliaro, P; Tazzari, PL; Brigotti, M,期刊:Biochemical Journal, 页码:173-180 , 文章类型: Article,,卷期:2010年432-Part 1]
- The main cause of acute renal failure in children is HUS (haemolytic uraemic syndrome), a consequence of intestinal infections with Escherichia coli strains producing Six (Shiga toxins). Stx released in the gut by the no...
- Functional domains of yeast hexokinase 2
[作者:Pelaez, R; Herrero, P; Moreno, F,期刊:Biochemical Journal, 页码:181-190 , 文章类型: Article,,卷期:2010年432-Part 1]
- Hkx2 (hexokinase 2) from Saccharomyces cerevisiae was one of the first metabolic enzymes described as a multifunctional protein. Hxk2 has a double subcellular localization: it functions as a glycolytic enzyme in the cyto...
- MicroRNA-7 targets IGF1R (insulin-like growth factor 1 receptor) in tongue squamous cell carcinoma cells
[作者:Jiang, L; Liu, XQ; Chen, ZJ; Jin, Y; Heidbreder, CE; Kolokythas, A; Wang, AX; Dai, Y; Zhou, XF,期刊:Biochemical Journal, 页码:199-205 , 文章类型: Article,,卷期:2010年432-Part 1]
- miR-7 (microRNA-7) has been characterized as a tumour suppressor in several human cancers. It targets a number of proto-oncogenes that contribute to cell proliferation and survival. However, the mechanism(s) by which miR...
- Prevention of diabetic nephropathy in Ins2(+/-AkitaJ) mice by the mitochondria-targeted therapy MitoQ
[作者:Chacko, BK; Reily, C; Srivastava, A; Johnson, MS; Ye, YZ; Ulasova, E; Agarwal, A; Zinn, KR; Murphy, MP; Kalyanaraman, B; Darley-Usmar, V,期刊:Biochemical Journal, 页码:9-19 , 文章类型: Article,,卷期:2010年432-Part 1]
- Mitochondrial production of ROS (reactive oxygen species) is thought to be associated with the cellular damage resulting from chronic exposure to high glucose in long-term diabetic patients. We hypothesized that a mitoch...
- High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules
[作者:Andrews, PD; Becroft, M; Aspegren, A; Gilmour, J; James, MJ; Mcrae, S; Kime, R; Allcock, RW; Abraham, A; Jiang, Z; Strehl, R; Mountford, JC; Milligan, G; Houslay, MD; Adams, DR; Frearson, JA,期刊:Biochemical Journal, 页码:21-33 , 文章类型: Article,,卷期:2010年432-Part 1]
- The propensity of human embryonic stem cells to die upon enzymatic disaggregation or low-density plating is an obstacle to their isolation and routine use in drug discovery and basic research. Equally, the very low rate ...
- Lysophosphatidylcholines activate G2A inducing G(alpha i-1)-/G(alpha q/11)- Ca2+ flux, G(beta gamma)-Hck activation and clathrin/beta-arrestin-1/GRK6 recruitment in PMNs
[作者:Khan, SY; McLaughlin, NJD; Kelher, MR; Eckels, P; Gamboni-Robertson, F; Banerjee, A; Silliman, CC,期刊:Biochemical Journal, 页码:35-45 , 文章类型: Article,,卷期:2010年432-Part 1]
- Lyso-PCs (lysophosphatidylcholines) are a mixture of lipids that accumulate during storage of cellular blood components, have been implicated in TRALI (transfusion-related acute lung injury) and directly affect the physi...
- Chondroitin sulfate N-acetylgalactosaminyltransferase-1 is required for normal cartilage development
[作者:Watanabe, Y; Takeuchi, K; Onaga, SH; Sato, M; Tsujita, M; Abe, M; Natsume, R; Li, MQ; Furuichi, T; Saeki, M; Izumikawa, T; Hasegawa, A; Yokoyama, M; Ikegawa, S; Sakimura, K; Amizuka, N; Kitagawa, H; Igarashi, M,期刊:Biochemical Journal, 页码:47-55 , 文章类型: Article,,卷期:2010年432-Part 1]
- CS (chondroitin sulfate) is a glycosaminoglycan species that is widely distributed in the extracellular matrix. To understand the physiological roles of enzymes involved in CS synthesis, we produced CSGalNAcT1 (CS N-acet...
- The role of vicinal tyrosine residues in the function of Haemophilus influenzae ferric-binding protein A
[作者:Khambati, HK; Moraes, TF; Singh, J; Shouldice, SR; Yu, RH; Schryvers, AB,期刊:Biochemical Journal, 页码:57-64 , 文章类型: Article,,卷期:2010年432-Part 1]
- The periplasmic FbpA (ferric-binding protein A) from Haemophilus influenzae plays a critical role in acquiring iron from host transferrin, shuttling iron from the outer-membrane receptor complex to the inner-membrane tra...
- Lipin proteins form homo- and hetero-oligomers
[作者:Liu, GH; Qu, J; Carmack, AE; Kim, HB; Chen, C; Ren, HM; Morris, AJ; Finck, BN; Harris, TE,期刊:Biochemical Journal, 页码:65-76 , 文章类型: Article,,卷期:2010年432-Part 1]
- Lipin family members (lipin 1, 2 and 3) are bi-functional proteins that dephosphorylate PA (phosphatidic acid) to produce DAG (diacylglycerol) and act in the nucleus to regulate gene expression. Although other components...
- Site-specific modification of calmodulin Ca2+ affinity tunes the skeletal muscle ryanodine receptor activation profile
[作者:Jiang, J; Zhou, YB; Zou, J; Chen, YY; Patel, P; Yang, JJ; Balog, EM,期刊:Biochemical Journal, 页码:89-99 , 文章类型: Article,,卷期:2010年432-Part 1]
- The skeletal muscle isoform of the ryanodine receptor Ca2+-release channel (RyR1) is regulated by Ca2+ and CaM (calmodulin). CaM shifts the biphasic Ca2+-dependence of RyR1 activation leftward, effectively increasing cha...
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