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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共30条记录   Geminal dialkyl derivatives of N-substituted pantothenamides: Synthesis and antibacterial activity [作者：AKINNUSI T OLUKAYODE; VONG KENWARD; AUCLAIR KARINE,期刊：Bioorganic & Medicinal Chemistry, 页码：2696-2706 , 文章类型： Article，,卷期：2011年19-8] As a key precursor of coenzyme A (CoA) biosynthesis, pantothenic acid has proven to be a useful backbone to elaborate probes of this biosynthetic pathway, study CoA-utilizing systems, and design molecules with antimicrob... Anti-tumor and anti-leishmanial evaluations of 1,3,4-oxadiazine, pyran derivatives derived from cross-coupling reactions of beta-bromo-6H-1,3,4-oxadiazine derivatives [作者：MOHAREB RAFAT M; SCHATZ JUERGEN,期刊：Bioorganic & Medicinal Chemistry, 页码：2707-2713 , 文章类型： Article，,卷期：2011年19-8] Cyanoacetylhydrazine reacted with the omega-bromoacetophenones 2a,b to give hydrazide-hydrazone derivatives 3a,b. The latter products were cyclized to the 1,3,4-oxadiazine derivatives 4a,b. Bromination of the latter prod... Fluorescent cyclin-dependent kinase inhibitors block the proliferation of human breast cancer cells [作者：YENUGONDA VENKATA MAHIDHAR; DEB TUSHAR B; GRINDROD SCOTT C; DAKSHANAMURTHY SIVANESAN; YANG YONGHONG; PAIGE MIKELL; BROWN MILTON L,期刊：Bioorganic & Medicinal Chemistry, 页码：2714-2725 , 文章类型： Article，,卷期：2011年19-8] Inhibitors of cyclin-dependent kinases (CDKs) are an emerging class of drugs for the treatment of cancers. CDK inhibitors are currently under evaluation in clinical trials as single agents and as sensitizers in combinati... 7-Azabicyclo[2.2.1]heptane as a structural motif to block mutagenicity of nitrosamines [作者：OHWADA TOMOHIKO; ISHIKAWA SATOKO; MINE YUSUKE; INAMI KEIKO; YANAGIMOTO TAKAHIRO; KARAKI FUMIKA; KABASAWA YOJI; OTANI YUKO; MOCHIZUKI MASATAKA,期刊：Bioorganic & Medicinal Chemistry, 页码：2726-2741 , 文章类型： Article，,卷期：2011年19-8] Nitrosamines are potent carcinogens and toxicants in the rat and potential genotoxins in humans. They are metabolically activated by hydroxylation at an alpha-carbon atom with respect to the nitrosoamino group, catalyzed... The synthesis and evaluation of indolylureas as PKC alpha inhibitors [作者：DJUNG JANE F; MEARS RICHARD J; MONTALBETTI CHRISTIAN A G N; COULTER THOMAS S; GOLEBIOWSKI ADAM; CARR ANDREW N; BARKER OLIVER; GREIS KENNETH D; ZHOU SONGTAO; DOLAN ELIZABETH; DAVIS GREGORY F,期刊：Bioorganic & Medicinal Chemistry, 页码：2742-2750 , 文章类型： Article，,卷期：2011年19-8] PKC alpha and PKA have crucial but opposing roles in the regulation of calcium handling within myocytes. Identification of compounds that inhibit PKC alpha, but not PKA, are potential therapeutic targets for the treatmen... Inhibitory effects of Mannich bases of heterocyclic chalcones on NO production by activated RAW 264.7 macrophages and superoxide anion generation and elastase release by activated human neutrophils [作者：REDDY M VIJAYA BHASKAR; HWANG TSONGLONG; LEU YANNLII; CHIOU WENFEI; WU TIANSHUNG,期刊：Bioorganic & Medicinal Chemistry, 页码：2751-2756 , 文章类型： Article，,卷期：2011年19-8] Some chalcones exert potent anti-inflammatory activities. Mannich bases of heterocyclic chalcones inhibited nitric oxide (NO) production in lipopolysaccharide and interferon-c stimulated RAW 264.7 macrophages. Also Formy... In vitro and QSAR studies of cucurbitacins on HepG2 and HSC-T6 liver cell lines [作者：BARTALIS JUDIT; HALAWEISH FATHI T,期刊：Bioorganic & Medicinal Chemistry, 页码：2757-2766 , 文章类型： Article，,卷期：2011年19-8] The aim of this study was to evaluate cucurbitacins (Cucs) liver protective activity in vitro and conduct QSAR studies against lipophilicity and ab initio descriptors. Nine Cucs were isolated from Cucurbitaceae plants an... Introduction of aromatic group on 4 '-OH of alpha-GalCer manipulated NKT cell cytokine production [作者：ZHANG WENPENG; XIA CHENGFENG; NADAS JANOS; CHEN WENLAN; GU LI; WANG PENG GEORGE,期刊：Bioorganic & Medicinal Chemistry, 页码：2767-2776 , 文章类型： Article，,卷期：2011年19-8] The glycosphingolipid alpha-GalCer has been found to influence mammalian immune system significantly through the natural killer T cells. Unfortunately, the pre-clinical and clinical studies revealed several critical disa... New and more efficient multivalent glyco-ligands for asialoglycoprotein receptor of mammalian hepatocytes [作者：LEE REIKO T; WANG MEIHUI; LIN WUUJYH; LEE YUAN C,期刊：Bioorganic & Medicinal Chemistry, 页码：2494-2500 , 文章类型： Article，,卷期：2011年19-8] New multi-valent, carbohydrate ligands that contain terminal N-acetylgalactosamine (GalNAc) or lactose (Lac) were prepared using a nitrilotriacetic acid (NTA) derivative of L-lysine as scaffold. Tri-valent structures wer... Diphenylamine-based retinoid antagonists: Regulation of RAR and RXR function depending on the N-substituent [作者：OHTA KIMINORI; KAWACHI EMIKO; FUKASAWA HIROSHI; SHUDO KOICHI; KAGECHIKA HIROYUKI,期刊：Bioorganic & Medicinal Chemistry, 页码：2501-2507 , 文章类型： Article，,卷期：2011年19-8] Based upon the structure-activity relationships of diphenylamine derivatives with retinoid synergistic activity (RXR agonists), novel diphenylamine derivatives with a long alkyl chain (9a and 9b) or a benzyl group (10a-f... Fluorescent phosphoinositide 3-kinase inhibitors suitable for monitoring of intracellular distribution [作者：KIM DONGHEE; LEE HYUNSEUNG; JUN HWISEOK; HONG SOONSUN; HONG SUNGWOO,期刊：Bioorganic & Medicinal Chemistry, 页码：2508-2516 , 文章类型： Article，,卷期：2011年19-8] The monitoring of the drug behavior and distribution in biological system can provide information whether drug reaches its desired target, and a biological rationale for the design of new therapeutics. We have developed ... Synthesis and pharmacological evaluation of thieno[2,3-b]pyridine derivatives as novel c-Src inhibitors [作者：PEVET ISABELLE; BRULE CEDRIC; TIZOT ANDRE; GOHIER ARNAUD; CRUZALEGUI FRANCISCO; BOUTIN JEAN A; GOLDSTEIN SOLO,期刊：Bioorganic & Medicinal Chemistry, 页码：2517-2528 , 文章类型： Article，,卷期：2011年19-8] Among the recently investigated targets for cancer therapy is the c-Src non-receptor tyrosine kinase. Indeed research around deregulated activity of this enzyme has proven its role in tumor progression, while the benefic... Synthesis and characterization of a cell-permeable bimodal contrast agent targeting beta-galactosidase [作者：KELIRIS ANETA; ZIEGLER THOMAS; MISHRA RITU; POHMANN ROLF; SAUER MARTIN G; UGURBIL KAMIL; ENGELMANN JOERN,期刊：Bioorganic & Medicinal Chemistry, 页码：2529-2540 , 文章类型： Article，,卷期：2011年19-8] Noninvasive monitoring of intracellular targets such as enzymes, receptors, or mRNA by means of magnetic resonance imaging (MRI) is increasingly gaining relevance in various research areas. A vital prerequisite for their... Synthesis and biological evaluation of tetracyclic thienopyridones as antibacterial and antitumor agents [作者：ALTRAWNEH SALAH A; ELABADELAH MUSTAFA M; ZAHRA JALAL A; ALTAWEEL SAMIR A; ZANI FRANCA; INCERTI MATTEO; CAVAZZONI ANDREA; VICINI PAOLA,期刊：Bioorganic & Medicinal Chemistry, 页码：2541-2548 , 文章类型： Article，,卷期：2011年19-8] A facile synthesis of model 4-oxopyrido[3',2':4,5]thieno[3,2-b]indole-3-carboxylic acids 9a-e was achieved via Stille arylation of 2-chloro-3-nitro-4-oxothieno[2,3-b]pyridine-5-carboxylate and a subsequent microwave-assi... Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand [作者：DE SOUZA MELISSA; MATTHEWS HAYDEN; LEE JODI A; RANSON MARIE; KELSO MICHAEL J,期刊：Bioorganic & Medicinal Chemistry, 页码：2549-2556 , 文章类型： Article，,卷期：2011年19-8] Binding of the urokinase-type plasminogen activator (uPA) to its cell-surface-bound receptor uPAR and upregulation of the plasminogen activation system (PAS) correlates with increased metastasis and poor prognosis in sev... Polyvalent saccharide-functionalized generation 3 poly(amidoamine) dendrimer-methotrexate conjugate as a potential anticancer agent [作者：ZHANG YUEHUA; THOMAS THOMMEY P; LEE KYUNGHOON; LI MINGHSIN; ZONG HONG; DESAI ANKUR M; KOTLYAR ALINA; HUANG BAOHUA; HOLL MARK M BANASZAK; BAKER JAMES R JR,期刊：Bioorganic & Medicinal Chemistry, 页码：2557-2564 , 文章类型： Article，,卷期：2011年19-8] A saccharide-terminated generation 3 (G3) polyamidoamine (PAMAM) dendrimer was synthesized as a drug carrier. Utilizing this dendritic platform, we have successfully synthesized polyvalent conjugates (G3-MTX) containing ...