- p53 Requires an Intact C-Terminal Domain for DNA Binding and Transactivation
[作者:Kim, H; Kim, K; Choi, J; Heo, K; Baek, HJ; Roeder, RG; An, WJ,期刊:Journal of Molecular Biology, 页码:843-854 , 文章类型: Article,,卷期:2012年415-5]
- The tumor suppressor p53 plays a critical role in mediating cellular response to a wide range of environmental stresses. p53 regulates these processes mainly by acting as a short-lived DNA binding protein that stimulates...
- Functional Defect and Restoration of Temperature-Sensitive Mutants of FlhA, a Subunit of the Flagellar Protein Export Apparatus
[作者:Shimada, M; Saijo-Hamano, Y; Furukawa, Y; Minamino, T; Imade, K; Namba, K,期刊:Journal of Molecular Biology, 页码:855-865 , 文章类型: Article,,卷期:2012年415-5]
- The flagellar axial component proteins are exported to the distal end of the growing flagellum for self-assembly by the flagellar type III export apparatus. FlhA is a key membrane protein of the export apparatus, and its...
- Structural Insights into the Allosteric Effects of 4EBP1 on the Eukaryotic Translation Initiation Factor eIF4E
[作者:Siddiqui, N; Tempel, W; Nedyalkova, L; Volpon, L; Wernimont, AK; Osborne, MJ; Park, HW; Borden, KLB,期刊:Journal of Molecular Biology, 页码:781-792 , 文章类型: Article,,卷期:2012年415-5]
- The eukaryotic translation initiation factor eIF4E plays key roles in cap-dependent translation and mRNA export. These functions rely on binding the 7-methyl-guanosine moiety (5'cap) on the 5'-end of all mRNAs. eIF4E is ...
- Slow Amyloid Nucleation via alpha-Helix-Rich Oligomeric Intermediates in Short Polyglutamine-Containing Huntingtin Fragments
[作者:Jayaraman, M; Kodali, R; Sahoo, B; Thakur, AK; Mayasundari, A; Mishra, R; Peterson, CB; Wetzel, R,期刊:Journal of Molecular Biology, 页码:881-899 , 文章类型: Article,,卷期:2012年415-5]
- The 17-amino-acid N-terminal segment (htt(NT)) that leads into the polyglutamine (polyQ) segment in the Huntington's disease protein huntingtin (htt) dramatically increases aggregation rates and changes the aggregation m...
- Inhibiting the Nucleation of Amyloid Structure in a Huntingtin Fragment by Targeting alpha-Helix-Rich Oligomeric Intermediates
[作者:Mishra, R; Jayaraman, M; Roland, BP; Landrum, E; Fullam, T; Kodali, R; Thakur, AK; Arduini, I; Wetzel, R,期刊:Journal of Molecular Biology, 页码:900-917 , 文章类型: Article,,卷期:2012年415-5]
- Although oligomeric intermediates are transiently formed in almost all known amyloid assembly reactions, their mechanistic roles are poorly understood. Recently, we demonstrated a critical role for the 17-amino-acid N-te...
- A Structural Basis for Sustained Bacterial Adhesion: Biomechanical Properties of CFA/I Pili
[作者:Andersson, M; Bjornham, O; Svantesson, M; Badandah, A; Uhlin, BE; Bullitt, E,期刊:Journal of Molecular Biology, 页码:918-928 , 文章类型: Article,,卷期:2012年415-5]
- Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrheal disease worldwide. Adhesion pill (or fimbriae), such as the CFA/I (colonization factor antigen I) organelles that enable ETEC to attach efficiently t...
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