- Rescue of the Transcription Factors Sp1 and NFI in Human Skin Keratinocytes through a Feeder-Layer-Dependent Suppression of the Proteasome Activity
[作者:Duval, C; Gaudreault, M; Vigneault, F; Touzel-Deschenes, L; Rochette, PJ; Masson-Gadais, B; Germain, L; Guerin, SL,期刊:Journal of Molecular Biology, 页码:281-299 , 文章类型: Article,,卷期:2012年418-5]
- Co-culturing human skin keratinocytes along with a feeder layer has proven to considerably improve their proliferative properties by delaying massive induction of terminal differentiation. Through a yet unclear mechanism...
- Mapping the Transition State for DNA Bending by IHF
[作者:Vivas, P; Velmurugu, Y; Kuznetsov, SV; Rice, PA; Ansari, A,期刊:Journal of Molecular Biology, 页码:300-315 , 文章类型: Article,,卷期:2012年418-5]
- How DNA-bending proteins recognize their specific sites on DNA remains elusive, particularly for proteins that use indirect readout, which relies on sequence-dependent variations in DNA flexibility/bendability. The quest...
- Impact of Ligand and Protein Desolvation on Ligand Binding to the S1 Pocket of Thrombin
[作者:Biela, A; Khayat, M; Tan, H; Kong, J; Heine, A; Hangauer, D; Klebe, G,期刊:Journal of Molecular Biology, 页码:350-366 , 文章类型: Article,,卷期:2012年418-5]
- In the present study, we investigate the impact of a tightly bound water molecule on ligand binding in the Si pocket of thrombin. The Si pocket contains a deeply buried deprotonated aspartate residue (Asp189) that is, du...
- Structural and Functional Dynamics of an Integral Membrane Protein Complex Modulated by Lipid Headgroup Charge
[作者:Li, J; James, ZM; Dong, XQ; Karim, CB; Thomas, DD,期刊:Journal of Molecular Biology, 页码:379-389 , 文章类型: Article,,卷期:2012年418-5]
- We have used membrane surface charge to modulate the structural dynamics of an integral membrane protein, phospholamban (PLB), and thereby its functional inhibition of the sarcoplasmic reticulum Ca-ATPase (SERCA). It was...
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