- Anaplastic Lymphoma Kinase Inhibition in Non-Small-Cell Lung Cancer
[作者：Kwak, EL; Bang, YJ; Camidge, DR; Shaw, AT; Solomon, B; Maki, RG; Ou, SHI; Dezube, BJ; Janne, PA; Costa, DB; Varella-Garcia, M; Kim, WH; Lynch, TJ; Fidias, P; Stubbs, H; Engelman, JA; Sequist, LV; Tan, WW; Gandhi, L; Mino-Kenudson, M; Wei, GC; Shreeve, SM; Ratain, MJ; Settleman, J; Christensen, JG; Haber, DA; Wilner, K; Salgia, R; Shapiro, GI; Clark, JW; Iafrate, AJ,期刊：New England Journal of Medicine, 页码：1693-1703 , 文章类型： Article，,卷期：2010年363-18]
- BACKGROUNDOncogenic fusion genes consisting of EML4 and anaplastic lymphoma kinase (ALK) are present in a subgroup of non-small-cell lung cancers, representing 2 to 7% of such tumors. We explored the therapeutic efficacy...
- Effects of CYP2C19 Genotype on Outcomes of Clopidogrel Treatment
[作者：Pare, G; Mehta, SR; Yusuf, S; Anand, SS; Connolly, SJ; Hirsh, J; Simonsen, K; Bhatt, DL; Fox, KAA; Eikelboom, JW,期刊：New England Journal of Medicine, 页码：1704-1714 , 文章类型： Article，,卷期：2010年363-18]
- BACKGROUNDIt has been suggested that clopidogrel may be less effective in reducing the rate of cardiovascular events among persons who are carriers of loss-of-function CYP2C19 alleles that are associated with reduced con...
- Tiotropium Bromide Step-Up Therapy for Adults with Uncontrolled Asthma
[作者：Peters, SP; Kunselman, SJ; Icitovic, N; Moore, WC; Pascual, R; Ameredes, BT; Boushey, HA; Calhoun, WJ; Castro, M; Cherniack, RM; Craig, T; Denlinger, L; Engle, LL; DiMango, EA; Fahy, JV; Israel, E; Jarjour, N; Kazani, SD; Kraft, M; Lazarus, SC; Lemanske, RF; Lugogo, N; Martin, RJ; Meyers, DA; Ramsdell, J; Sorkness, CA; Sutherland, ER; Szefler, SJ; Wasserman, SI; Walter, MJ; Wechsler, ME; Chinchilli, VM; Bleecker, ER,期刊：New England Journal of Medicine, 页码：1715-1726 , 文章类型： Article，,卷期：2010年363-18]
- BACKGROUNDLong-acting beta-agonist (LABA) therapy improves symptoms in patients whose asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for adults with uncontrolled asthma are needed....
- Crizotinib in ALK-Rearranged Inflammatory Myofibroblastic Tumor
[作者：Butrynski, JE; D'Adamo, DR; Hornick, JL; Dal Cin, P; Antonescu, CR; Jhanwar, SC; Ladanyi, M; Capelletti, M; Rodig, SJ; Ramaiya, N; Kwak, EL; Clark, JW; Wilner, KD; Christensen, JG; Janne, PA; Maki, RG; Demetri, GD; Shapiro, GI,期刊：New England Journal of Medicine, 页码：1727-1733 , 文章类型： Article，,卷期：2010年363-18]
- Inflammatory myofibroblastic tumor (IMT) is a distinctive mesenchymal neoplasm characterized by a spindle-cell proliferation with an inflammatory infiltrate. Approximately half of IMTs carry rearrangements of the anaplas...
- EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors
[作者：Choi, YL; Soda, M; Yamashita, Y; Ueno, T; Takashima, J; Nakajima, T; Yatabe, Y; Takeuchi, K; Hamada, T; Haruta, H; Ishikawa, Y; Kimura, H; Mitsudomi, T; Tanio, Y; Mano, H,期刊：New England Journal of Medicine, 页码：1734-1739 , 文章类型： Article，,卷期：2010年363-18]
- The EML4 (echinoderm microtubule-associated protein-like 4)-ALK (anaplastic lymphoma kinase) fusion-type tyrosine kinase is an oncoprotein found in 4 to 5% of non-small-cell lung cancers, and clinical trials of specific ...
- Recurrent Miscarriage
[作者：Branch, DW; Gibson, M; Silver, RM,期刊：New England Journal of Medicine, 页码：1740-1747 , 文章类型： Article，,卷期：2010年363-18]
- A 32-year-old woman presents for evaluation after three consecutive miscarriages. Before these miscarriages, she had one successful pregnancy. The patient reports no medical problems or previous surgeries. In her first m...
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