- Downregulation of Rap1GAP in Human Tumor Cells Alters Cell/Matrix and Cell/Cell Adhesion
[作者:Tsygankova, OM; Ma, CQ; Tang, WX; Korch, C; Feldman, MD; Lv, Y; Brose, MS; Meinkoth, JL,期刊:Molecular and Cellular Biology, 页码:3262-3274 , 文章类型: Article,,卷期:2010年30-13]
- Rap1GAP expression is decreased in human tumors. The significance of its downregulation is unknown. We show that Rap1GAP expression is decreased in primary colorectal carcinomas. To elucidate the advantages conferred on ...
- The Prodomain of Ssy5 Protease Controls Receptor-Activated Proteolysis of Transcription Factor Stp1
[作者:Pfirrmann, T; Heessen, S; Omnus, DJ; Andreasson, C; Ljungdahl, PO,期刊:Molecular and Cellular Biology, 页码:3299-3309 , 文章类型: Article,,卷期:2010年30-13]
- Extracellular amino acids induce the yeast SPS sensor to endoproteolytically cleave transcription factors Stp1 and Stp2 in a process termed receptor-activated proteolysis (RAP). Ssy5, the activating endoprotease, is synt...
- A Noncanonical Mechanism of Nrf2 Activation by Autophagy Deficiency: Direct Interaction between Keap1 and p62
[作者:Lau, A; Wang, XJ; Zhao, F; Villeneuve, NF; Wu, TD; Jiang, T; Sun, Z; White, E; Zhang, DD,期刊:Molecular and Cellular Biology, 页码:3275-3285 , 文章类型: Article,,卷期:2010年30-13]
- In response to stress, cells can utilize several cellular processes, such as autophagy, which is a bulk-lysosomal degradation pathway, to mitigate damages and increase the chances of cell survival. Deregulation of autoph...
- PHF8 Targets Histone Methylation and RNA Polymerase II To Activate Transcription
[作者:Fortschegger, K; de Graaf, P; Outchkourov, NS; van Schaik, FMA; Timmers, HTM; Shiekhattar, R,期刊:Molecular and Cellular Biology, 页码:3286-3298 , 文章类型: Article,,卷期:2010年30-13]
- Mutations in PHF8 are associated with X-linked mental retardation and cleft lip/cleft palate. PHF8 contains a plant homeodomain (PHD) in its N terminus and is a member of a family of JmjC domain-containing proteins. Whil...
- The Transcription Factor TCFAP2C/AP-2 gamma Cooperates with CDX2 To Maintain Trophectoderm Formation
[作者:Kuckenberg, P; Buhl, S; Woynecki, T; van Fuerden, B; Tolkunova, E; Seiffe, F; Moser, M; Tomilin, A; Winterhager, E; Schorle, H,期刊:Molecular and Cellular Biology, 页码:3310-3320 , 文章类型: Article,,卷期:2010年30-13]
- In mammals, cell lineage specification is established at the blastocyst stage. At this stage, transcription factor Cdx2 represses pluripotency genes, thus promoting extraembryonic trophoblast fate. Recently, transcriptio...
- Successful Computational Prediction of Novel Imprinted Genes from Epigenomic Features
[作者:Brideau, CM; Eilertson, KE; Hagarman, JA; Bustamante, CD; Soloway, PD,期刊:Molecular and Cellular Biology, 页码:3357-3370 , 文章类型: Article,,卷期:2010年30-13]
- Approximately 100 mouse genes undergo genomic imprinting, whereby one of the two parental alleles is epigenetically silenced. Imprinted genes influence processes including development, X chromosome inactivation, obesity,...
- Role of ATM and the Damage Response Mediator Proteins 53BP1 and MDC1 in the Maintenance of G(2)/M Checkpoint Arrest
[作者:Shibata, A; Barton, O; Noon, AT; Dahm, K; Deckbar, D; Goodarzi, AA; Lobrich, M; Jeggo, PA,期刊:Molecular and Cellular Biology, 页码:3371-3383 , 文章类型: Article,,卷期:2010年30-13]
- ATM-dependent initiation of the radiation-induced G(2)/M checkpoint arrest is well established. Recent results have shown that the majority of DNA double-strand breaks (DSBs) in G(2) phase are repaired by DNA nonhomologo...
- Transcriptional Activation of the General Amino Acid Permease Gene per1 by the Histone Deacetylase Clr6 Is Regulated by Oca2 Kinase
[作者:Kaufmann, I; White, E; Azad, A; Marguerat, S; Bahler, J; Proudfoot, NJ,期刊:Molecular and Cellular Biology, 页码:3396-3410 , 文章类型: Article,,卷期:2010年30-13]
- Expression of nitrogen metabolism genes is regulated by the quality of the nitrogen supply. Here, we describe a mechanism for the transcriptional regulation of the general amino acid permease gene per1 in Schizosaccharom...
- Recruitment of Cdc20 to the Kinetochore Requires BubR1 but Not Mad2 in Drosophila melanogaster
[作者:Li, DY; Morley, G; Whitaker, M; Huang, JY,期刊:Molecular and Cellular Biology, 页码:3384-3395 , 文章类型: Article,,卷期:2010年30-13]
- To prevent aneuploidy, cells require a mitotic surveillance mechanism, the spindle assembly checkpoint (SAC). The SAC prevents metaphase/anaphase transition by blocking the ubiquitylation and destruction of cyclin B and ...
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