- Differential Regulation of HIC1 Target Genes by CtBP and NuRD, via an Acetylation/SUMOylation Switch, in Quiescent versus Proliferating Cells
[作者:Van Rechem, C; Boulay, G; Pinte, S; Stankovic-Valentin, N; Guerardel, C; Leprince, D,期刊:Molecular and Cellular Biology, 页码:4045-4059 , 文章类型: Article,,卷期:2010年30-16]
- The tumor suppressor gene HIC1 encodes a transcriptional repressor involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. Despite its importance, few...
- Inactivation of Foxo3a and Subsequent Downregulation of PGC-1 alpha Mediate Nitric Oxide-Induced Endothelial Cell Migration
[作者:Borniquel, S; Garcia-Quintans, N; Valle, I; Olmos, Y; Wild, B; Martinez-Granero, F; Soria, E; Lamas, S; Monsalve, M,期刊:Molecular and Cellular Biology, 页码:4035-4044 , 文章类型: Article,,卷期:2010年30-16]
- In damaged or proliferating endothelium, production of nitric oxide (NO) from endothelial nitric oxide synthase (eNOS) is associated with elevated levels of reactive oxygen species (ROS), which are necessary for endothel...
- Epidermis-Type Lipoxygenase 3 Regulates Adipocyte Differentiation and Peroxisome Proliferator-Activated Receptor gamma Activity
[作者:Hallenborg, P; Jorgensen, C; Petersen, RK; Feddersen, S; Araujo, P; Markt, P; Langer, T; Furstenberger, G; Krieg, P; Koppen, A; Kalkhoven, E; Madsen, L; Kristiansen, K,期刊:Molecular and Cellular Biology, 页码:4077-4091 , 文章类型: Article,,卷期:2010年30-16]
- The nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR gamma) is essential for adipogenesis. Although several fatty acids and their derivatives are known to bind and activate PPAR gamma, the nature o...
- In Vitro Reconstitution of PHO5 Promoter Chromatin Remodeling Points to a Role for Activator-Nucleosome Competition In Vivo
[作者:Ertel, F; Dirac-Svejstrup, AB; Hertel, CB; Blaschke, D; Svejstrup, JQ; Korber, P,期刊:Molecular and Cellular Biology, 页码:4060-4076 , 文章类型: Article,,卷期:2010年30-16]
- The yeast PHO5 promoter is a classical model for studying the role of chromatin in gene regulation. To enable biochemical dissection of the mechanism leading to PHO5 activation, we reconstituted the process in vitro. Pos...
- Domain-Specific Response of Imprinted Genes to Reduced DNMT1
[作者:Weaver, JR; Sarkisian, G; Krapp, C; Mager, J; Mann, MRW; Bartolomei, MS,期刊:Molecular and Cellular Biology, 页码:3916-3928 , 文章类型: Article,,卷期:2010年30-16]
- Imprinted genes are expressed in a monoallelic, parent-of-origin-specific manner. Clusters of imprinted genes are regulated by imprinting control regions (ICRs) characterized by DNA methylation of one allele. This methyl...
- Zinc Finger Protein Gfi1 Controls the Endotoxin-Mediated Toll-Like Receptor Inflammatory Response by Antagonizing NF-kappa B p65
[作者:Sharif-Askari, E; Vassen, L; Kosan, C; Khandanpour, C; Gaudreau, MC; Heyd, F; Okayama, T; Jin, JM; Rojas, MEB; Grimes, HL; Zeng, H; Moroy, T,期刊:Molecular and Cellular Biology, 页码:3929-3942 , 文章类型: Article,,卷期:2010年30-16]
- Endotoxin (bacterial lipopolysaccharide [LPS]) causes fatal septic shock via the Toll-like receptor 4 (TLR-4) protein present on innate immunity effector cells, which activates nuclear factor kappa B (NF-kappa B), induci...
- The Interaction of Epac1 and Ran Promotes Rap1 Activation at the Nuclear Envelope
[作者:Liu, C; Takahashi, M; Li, YP; Dillon, TJ; Kaech, S; Stork, PJS,期刊:Molecular and Cellular Biology, 页码:3956-3969 , 文章类型: Article,,卷期:2010年30-16]
- Epac1 (exchange protein directly activated by cyclic AMP [cAMP]) couples intracellular cAMP to the activation of Rap1, a Ras family GTPase that regulates cell adhesion, proliferation, and differentiation. Using mass spec...
- Analysis of CUGBP1 Targets Identifies GU-Repeat Sequences That Mediate Rapid mRNA Decay
[作者:Rattenbacher, B; Beisang, D; Wiesner, DL; Jeschke, JC; von Hohenberg, M; St Louis-Vlasova, IA; Bohjanen, PR,期刊:Molecular and Cellular Biology, 页码:3970-3980 , 文章类型: Article,,卷期:2010年30-16]
- CUG-repeat binding protein 1 (CUGBP1) mediates selective mRNA decay by binding to GU-rich elements (GREs) containing the sequence UGUUUGUUUGU found in the 3' untranslated region (UTR) of short-lived transcripts. We used ...
- Genome-Wide Analysis of Estrogen Receptor alpha DNA Binding and Tethering Mechanisms Identifies Runx1 as a Novel Tethering Factor in Receptor-Mediated Transcriptional Activation
[作者:Stender, JD; Kim, K; Charn, TH; Komm, B; Chang, KCN; Kraus, WL; Benner, C; Glass, CK; Katzenellenbogen, BS,期刊:Molecular and Cellular Biology, 页码:3943-3955 , 文章类型: Article,,卷期:2010年30-16]
- Nuclear receptor estrogen receptor alpha (ER alpha) controls the expression of hundreds of genes responsible for target cell phenotypic properties, but the relative importance of direct versus tethering mechanisms of DNA...
- The Anaphase-Promoting Complex/Cyclosome Activator Cdh1 Modulates Rho GTPase by Targeting p190 RhoGAP for Degradation
[作者:Naoe, H; Araki, K; Nagano, O; Kobayashi, Y; Ishizawa, J; Chiyoda, T; Shimizu, T; Yamamura, K; Sasaki, Y; Saya, H; Kuninaka, S,期刊:Molecular and Cellular Biology, 页码:3994-4005 , 文章类型: Article,,卷期:2010年30-16]
- Cdh1 is an activator of the anaphase-promoting complex/cyclosome and contributes to mitotic exit and G(1) maintenance by targeting cell cycle proteins for degradation. However, Cdh1 is expressed and active in postmitotic...
- Mitochondrial HEP27 Is a c-Myb Target Gene That Inhibits Mdm2 and Stabilizes p53
[作者:Deisenroth, C; Thorner, AR; Enomoto, T; Perou, CM; Zhang, YP,期刊:Molecular and Cellular Biology, 页码:3981-3993 , 文章类型: Article,,卷期:2010年30-16]
- The ever-expanding knowledge of the role of p53 in cellular metabolism, apoptosis, and cell cycle control has led to increasing interest in defining the stress response pathways that regulate Mdm2. In an effort to identi...
- The Repressing Function of the Oncoprotein BCL-3 Requires CtBP, while Its Polyubiquitination and Degradation Involve the E3 Ligase TBLR1
[作者:Keutgens, A; Shostak, K; Close, P; Zhang, X; Hennuy, B; Aussems, M; Chapelle, JP; Viatour, P; Gothot, A; Fillet, M; Chariot, A,期刊:Molecular and Cellular Biology, 页码:4006-4021 , 文章类型: Article,,卷期:2010年30-16]
- The nuclear and oncogenic BCL-3 protein activates or represses gene transcription when bound to NF-kappa B proteins p50 and p52, yet the molecules that specifically interact with BCL-3 and drive BCL-3-mediated effects on...
|