- Synthesis of sulfonyl flosulide
[作者:Black, WC; Guay, B,期刊:Synthesis, 页码:1101-1103 , 文章类型: Article,,卷期:1998年-8]
- The sulfone analogue of the selective cyclooxygenase-2 inhibitor flosulide (1) has been prepared in an eight step synthesis. A key step involves a thiol conjugate addition reaction followed by nucleophilic aromatic subst...
- Convenient and simplified approaches to N-monoprotected triaminopropane derivatives: Key intermediates for bifunctional chelating agent synthesis
[作者:Benoist, E; Loussouarn, A; Remaud, P; Chatal, JF; Gestin, JF,期刊:Synthesis, 页码:1113-1118 , 文章类型: Article,,卷期:1998年-8]
- High yields of selectively N-protected-1,2,3-triaminopropanes (1,3 or 1,2 functionalized diamines) were obtained in 6 or 4 steps from diamino alcohols or aminodiols, respectively. These two multi-step procedures involve ...
- Conjugate addition of amidoalkyl zinc-copper reagents to a propyne iminium triflate
[作者:Reisser, M; Maas, G,期刊:Synthesis, 页码:1129-1132 , 文章类型: Article,,卷期:1998年-8]
- Zinc-copper reagents of the type IZnCu(CN)-(CH2)(n)-(NRR2)-R-1, obtained from N-(2-iodoethyl)phthalimide, N-(2-iodopropyl)phthalimide, and N-(2-iodoethyl)benzamide, undergo conjugate addition to propyne iminium triflate ...
- The use of Nafion (R)-H to promote epoxide cyclizations
[作者:Taylor, SK; Dickinson, MG; May, SA; Pickering, DA; Sadek, PC,期刊:Synthesis, 页码:1133-1136 , 文章类型: Article,,卷期:1998年-8]
- Nafion(R)-H is shown to be an effective promoter of epoxide cyclizations to aromatic positions. The reactions can be done by passing a solution of the epoxide through a column packed with Nafion(R)-H, or by stirring a mi...
- Synthesis of 5-oxatrienes: Useful intermediates for the preparation of hexahydrobenzofuran structures by intramolecular Diels-Alder reaction
[作者:Deagostino, A; Prandi, C; Venturello, P,期刊:Synthesis, 页码:1149-1152 , 文章类型: Article,,卷期:1998年-8]
- The metalation with the Schlosser's base LICKOR (alkyllithium potassium alcoholate) at the gamma terminus, selectively induces 1,4-elimination reaction in cyclic alpha,beta-unsaturated acetals, and in this way hydroxy-fu...
- Application of erythro-2-amino-1,2-diphenylethanol as a highly efficient chiral auxiliary. Highly stereoselective Staudinger-type beta-lactam synthesis using a 2-chloro-1-methylpyridinium salt as the dehydrating agent
[作者:Matsui, S; Hashimoto, Y; Saigo, K,期刊:Synthesis, 页码:1161-1166 , 文章类型: Article,,卷期:1998年-8]
- The Staudinger-type reaction of carboxylic acids with imines, using a 2-chloro-1-methylpyridinium salt as the dehydrating reagent, proceeded smoothly under mild conditions to afford the desired beta-lactams in high yield...
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