- In vitro modeling of respiratory syncytial virus infection of pediatric bronchial epithelium, the primary target of infection in vivo
[作者:Villenave, R; Thavagnanam, S; Sarlang, S; Parker, J; Douglas, I; Skibinski, G; Heaney, LG; McKaigue, JP; Coyle, PV; Shields, MD; Power, UF,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5040-5045 , 文章类型: Article,,卷期:2012年109-13]
- Respiratory syncytial virus (RSV) is the major viral cause of severe pulmonary disease in young infants worldwide. However, the mechanisms by which RSV causes disease in humans remain poorly understood. To help bridge th...
- Crimean-Congo hemorrhagic fever virus nucleoprotein reveals endonuclease activity in bunyaviruses
[作者:Guo, Y; Wang, WM; Ji, W; Deng, MP; Sun, YN; Zhou, HG; Yang, C; Deng, F; Wang, HL; Hu, ZH; Lou, ZY; Rao, ZH,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5046-5051 , 文章类型: Article,,卷期:2012年109-13]
- Crimean-Congo hemorrhagic fever virus (CCHFV), a virus with high mortality in humans, is a member of the genus Nairovirus in the family Bunyaviridae, and is a causative agent of severe hemorrhagic fever (HF). It is class...
- Insights from past millennia into climatic impacts on human health and survival
[作者:McMichael, AJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4730-4737 , 文章类型: Article,,卷期:2012年109-13]
- Climate change poses threats to human health, safety, and survival via weather extremes and climatic impacts on food yields, fresh water, infectious diseases, conflict, and displacement. Paradoxically, these risks to hea...
- Reconfigurable interactions and three-dimensional patterning of colloidal particles and defects in lamellar soft media
[作者:Trivedi, RP; Klevets, II; Senyuk, B; Lee, T; Smalyukh, II,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4744-4749 , 文章类型: Article,,卷期:2012年109-13]
- Colloidal systems find important applications ranging from fabrication of photonic crystals to direct probing of phenomena typically encountered in atomic crystals and glasses. New applications-such as nanoantennas, plas...
- Rescue of neuronal migration deficits in a mouse model of fetal Minamata disease by increasing neuronal Ca2+ spike frequency
[作者:Fahrion, JK; Komuro, Y; Li, Y; Ohno, N; Littner, Y; Raoult, E; Galas, L; Vaudry, D; Komuro, H,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5057-5062 , 文章类型: Article,,卷期:2012年109-13]
- In the brains of patients with fetal Minamata disease (FMD), which is caused by exposure to methylmercury (MeHg) during development, many neurons are hypoplastic, ectopic, and disoriented, indicating disrupted migration,...
- Tomato immune receptor Ve1 recognizes effector of multiple fungal pathogens uncovered by genome and RNA sequencing
[作者:de Jonge, R; van Esse, HP; Maruthachalam, K; Bolton, MD; Santhanam, P; Saber, MK; Zhang, Z; Usami, T; Lievens, B; Subbarao, KV; Thomma, BPHJ,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5110-5115 , 文章类型: Article,,卷期:2012年109-13]
- Fungal plant pathogens secrete effector molecules to establish disease on their hosts, and plants in turn use immune receptors to try to intercept these effectors. The tomato immune receptor Ve1 governs resistance to rac...
- Selective esterase-ester pair for targeting small molecules with cellular specificity
[作者:Tian, L; Yang, YL; Wysocki, LM; Arnold, AC; Hu, A; Ravichandran, B; Sternson, SM; Looger, LL; Lavis, LD,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4756-4761 , 文章类型: Article,,卷期:2012年109-13]
- Small molecules are important tools to measure and modulate intracellular signaling pathways. A longstanding limitation for using chemical compounds in complex tissues has been the inability to target bioactive small mol...
- Reactive polymer enables efficient in vivo bioorthogonal chemistry
[作者:Devaraj, NK; Thurber, GM; Keliher, EJ; Marinelli, B; Weissleder, R,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4762-4767 , 文章类型: Article,,卷期:2012年109-13]
- There has been intense interest in the development of selective bioorthogonal reactions or "click" chemistry that can proceed in live animals. Until now however, most reactions still require vast surpluses of reactants b...
- A sulfated carbohydrate epitope inhibits axon regeneration after injury
[作者:Brown, JM; Xia, J; Zhuang, BQ; Cho, KS; Rogers, CJ; Gama, CI; Rawat, M; Tully, SE; Uetani, N; Mason, DE; Tremblay, ML; Peters, EC; Habuchi, O; Chen, DF; Hsieh-Wilson, LC,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:4768-4773 , 文章类型: Article,,卷期:2012年109-13]
- Chondroitin sulfate proteoglycans (CSPGs) represent a major barrier to regenerating axons in the central nervous system (CNS), but the structural diversity of their polysaccharides has hampered efforts to dissect the str...
- Synaptic evidence for the efficacy of spaced learning
[作者:Kramar, EA; Babayan, AH; Gavin, CF; Cox, CD; Jafari, M; Gall, CM; Rumbaugh, G; Lynch, G,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:5121-5126 , 文章类型: Article,,卷期:2012年109-13]
- The superiority of spaced vs. massed training is a fundamental feature of learning. Here, we describe unanticipated timing rules for the production of long-term potentiation (LTP) in adult rat hippocampal slices that can...
- Evidence from central Mexico supporting the Younger Dryas extraterrestrial impact hypothesis
[作者:Israde-Alcantara, I; Bischoff, JL; Dominguez-Vazquez, G; Li, HC; DeCarli, PS; Bunch, TE; Wittke, JH; Weaver, JC; Firestone, RB; West, A; Kennett, JP; Mercer, C; Xie, SJ; Richman, EK; Kinzie, CR; Wolbach, WS,期刊:Proceedings of the National Academy of Sciences of the United States of America, 页码:E738-E747 , 文章类型: Article,,卷期:2012年109-13]
- We report the discovery in Lake Cuitzeo in central Mexico of a black, carbon-rich, lacustrine layer, containing nanodiamonds, microspherules, and other unusual materials that date to the early Younger Dryas and are inter...
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