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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共8条记录   Novel TACE inhibitors in drug discovery: a review of patented compounds [作者：Murumkar, PR; DasGupta, S; Chandani, SR; Giridhar, R; Yadav, MR,期刊：Expert Opinion on Therapeutic Patents, 页码：31-57 , 文章类型： Review，,卷期：2010年20-1] TNF-alpha converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-alpha from membrane bound TNF-alpha precursor protein. TNF-alpha is believed to play pathophysiological roles in inflammatio... Inhibitors of diacylglycerol acyltransferase: a review of 2008 patents [作者：King, AJ; Judd, AS; Souers, AJ,期刊：Expert Opinion on Therapeutic Patents, 页码：19-29 , 文章类型： Review，,卷期：2010年20-1] Background. Postprandial hypertriglyceridemia has been identified as a major independent risk factor for future cardiovascular events. Therefore, inhibition of triglyceride synthesis has enormous therapeutic potential in... Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors [作者：Wang, HM; Liang, PH,期刊：Expert Opinion on Therapeutic Patents, 页码：59-71 , 文章类型： Review，,卷期：2010年20-1] Importance of the field: Picornaviruses are small non-enveloped RNA viruses with genomic RNA of 7500 - 8000 nuclecitides, whereas coronaviruses (CoV) are RNA viruses with larger genome of 27 - 32 kb. Both types of viruse... Radiation countermeasure agents: an update [作者：Dumont, F; Le Roux, A; Bischoff, P,期刊：Expert Opinion on Therapeutic Patents, 页码：73-101 , 文章类型： Review，,卷期：2010年20-1] Importance of the field: Ionizing radiation (IR) can produce deleterious effects in living tissues, leading to significant morbidity and a potentially fatal illness affecting various organs dose-dependently. As people ma... Heterocyclic indazole derivatives as SGK1 inhibitors, WO2008138448 [作者：Lang, F; Gorlach, A,期刊：Expert Opinion on Therapeutic Patents, 页码：129-135 , 文章类型： Article，,卷期：2010年20-1] Heterocyclic indazole derivatives are claimed in patent WO2008138448 as inhibitors of the serum- and glucocorticoid-inducible-kinase 1 (SGK1) and drugs for the pharmacological treatment of SGK1-related diseases, such as ... Antifungal agents, WO2009025733 [作者：Sudhir, PV; Ranan, DS; Ganpat, AN,期刊：Expert Opinion on Therapeutic Patents, 页码：137-143 , 文章类型： Article，,卷期：2010年20-1] Background: The incidence and prevalence of serious mycoses continues to be a public health problem. These infections are an important cause of morbidity and mortality, especially in immunocompromised patients. The prese... Anti-VEGF agents for age-related macular degeneration [作者：Ozkiris, A,期刊：Expert Opinion on Therapeutic Patents, 页码：103-118 , 文章类型： Review，,卷期：2010年20-1] Age-related macular degeneration (AMD) is a leading cause of legal blindness in the elderly in the industrialized world and the third major cause of blindness around the globe. Although neovascular AMD is less prevalent ... Phospholipase A(2) inhibitors as potential therapeutic agents for the treatment of inflammatory diseases [作者：Magrioti, V; Kokotos, G,期刊：Expert Opinion on Therapeutic Patents, 页码：1-18 , 文章类型： Review，,卷期：2010年20-1] Importance of the field. The various phospholipase A(2) (PLA(2)) types have been implicated in diverse kinds of lipid signaling and inflammatory diseases. Rheumatoid arthritis, lung inflammation, neurological disorders, ...