- Pluripotency associated genes are reactivated by chromatin-modifying agents in neurosphere cells
[作者:Ruau, D; Ensenat-Waser, R; Dinger, TC; Vallabhapurapu, DS; Rolletschek, A; Hacker, C; Hieronymus, T; Wobus, AM; Muller, AM; Zenke, M,期刊:Stem Cells, 页码:920-926 , 文章类型: Article,,卷期:2008年26-4]
- Chromatin architecture in stem cells determines the pattern of gene expression and thereby cell identity and fate. The chromatin-modifying agents trichostatin A (TSA) and 5-Aza-2'-deoxycytidine (AzaC) affect histone acet...
- Genes involved in post-transcriptional regulation are overrepresented in stem/progenitor spermatogonia of cryptorchid mouse testes
[作者:Orwig, KE; Ryu, BY; Master, SR; Phillips, BT; Mack, M; Avarbock, MR; Chodosh, L; Brinster, RL,期刊:Stem Cells, 页码:927-938 , 文章类型: Article,,卷期:2008年26-4]
- Gene expression and consequent biological activity of adult tissue stem cells are regulated by signals emanating from the local microenvironment (niche). To gain insights into the molecular regulation of spermatogonial s...
- Derivation of neurons with functional properties from adult limbal epithelium: Implications in autologous cell therapy for photoreceptor degeneration
[作者:Zhao, X; Das, AV; Bhattacharya, S; Thoreson, WB; Sierra, JR; Mallya, KB; Ahmad, I,期刊:Stem Cells, 页码:939-949 , 文章类型: Article,,卷期:2008年26-4]
- The limbal epithelium (LE), a circular and narrow epithelium that separates cornea from conjunctiva, harbors stem cells/progenitors in its basal layer that regenerate cornea. We have previously demonstrated that cells in...
- Tumor necrosis factor-alpha inhibition of skeletal muscle regeneration is mediated by a caspase-dependent stem cell response
[作者:Moresi, V; Pristera, A; Scicchitano, BM; Molinaro, M; Teodori, L; Sassoon, D; Adamo, S; Coletti, D,期刊:Stem Cells, 页码:997-1008 , 文章类型: Article,,卷期:2008年26-4]
- Skeletal muscle is susceptible to injury following trauma, neurological dysfunction, and genetic diseases. Skeletal muscle homeostasis is maintained by a pronounced regenerative capacity, which includes the recruitment o...
- Vaccinia virus infection modulates the hematopoietic cell compartments in the bone marrow
[作者:Singh, P; Yao, YX; Weliver, A; Broxmeyer, HE; Hong, SC; Chang, CH,期刊:Stem Cells, 页码:1009-1016 , 文章类型: Article,,卷期:2008年26-4]
- Successful proliferation and differentiation of hematopoietic progenitor cells in bone marrow (BM) is essential to generate all mature blood cell types, including those involved in the immune response. Although vaccinia ...
- Sustained endothelial progenitor cell dysfunction after chronic hypoxia-induced pulmonary hypertension
[作者:Marsboom, G; Pokreisz, P; Gheysens, O; Vermeersch, P; Gillijns, H; Pellens, M; Liu, XS; Collen, D; Janssens, S,期刊:Stem Cells, 页码:1017-1026 , 文章类型: Article,,卷期:2008年26-4]
- Circulating endothelial progenitor cells (EPCs) contribute to neovascularization of ischemic tissues and repair of injured endothelium. The role of bone marrow-derived progenitor cells in hypoxia-induced pulmonary vascul...
- Gli1 induces G2/M arrest and apoptosis in hippocampal but not tumor-derived neural stem cells
[作者:Galvin, KE; Ye, H; Erstad, DJ; Feddersen, R; Wetmore, C,期刊:Stem Cells, 页码:1027-1036 , 文章类型: Article,,卷期:2008年26-4]
- Sonic hedgehog (Shh) is necessary for sustaining the proliferation of neural stem cells (NSCs), yet little is known about its mechanisms. Whereas Gli1, Gli2, and Gli3, the primary mediators of Shh signaling, were all exp...
- Hedgehog signaling alters adipocyte maturation of human mesenchymal stem cells
[作者:Fontaine, C; Cousin, W; Plaisant, M; Dani, C; Peraldi, P,期刊:Stem Cells, 页码:1037-1046 , 文章类型: Article,,卷期:2008年26-4]
- Human stem cells are powerful tools by which to investigate molecular mechanisms of cell growth and differentiation under normal and pathological conditions. Hedgehog signaling, the dysregulation of which causes several ...
- Role of CD34 antigen in myeloid differentiation of human hematopoietic progenitor cells
[作者:Salati, S; Zini, R; Bianchi, E; Testa, A; Mavilio, F; Manfredini, R; Ferrari, S,期刊:Stem Cells, 页码:950-959 , 文章类型: Article,,卷期:2008年26-4]
- CD34 is a transmembrane protein that is strongly expressed on hematopoietic stem/progenitor cells (HSCs); despite its importance as a marker of HSCs, its function is still poorly understood, although a role in cell adhes...
- Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells
[作者:Chen, CT; Shih, YRV; Kuo, TK; Lee, OK; Wei, YH,期刊:Stem Cells, 页码:960-968 , 文章类型: Article,,卷期:2008年26-4]
- The multidifferentiation ability of mesenchymal stem cells holds great promise for cell therapy. Numerous studies have focused on the establishment of differentiation protocols, whereas little attention has been paid to ...
- Adipogenic human adenovirus Ad-36 induces commitment, differentiation, and lipid accumulation in human adipose-derived stem cells
[作者:Pasarica, M; Mashtalir, N; McAllister, EJ; Kilroy, GE; Koska, J; Permana, P; De Courten, B; Yu, MH; Ravussin, E; Gimble, JM; Dhurandhar, NV,期刊:Stem Cells, 页码:969-978 , 文章类型: Article,,卷期:2008年26-4]
- Human adenovirus Ad-36 is causatively and correlatively linked with animal and human obesity, respectively. Ad-36 enhances differentiation of rodent preadipocytes, but its effect on adipogenesis in humans is unknown. To ...
- Comparative analysis of the frequency and distribution of stem and progenitor cells in the adult mouse brain
[作者:Golmohammadi, MG; Blackmore, DG; Large, B; Azari, H; Esfandiary, E; Paxinos, G; Franklin, KBJ; Reynolds, BA; Rietze, RL,期刊:Stem Cells, 页码:979-987 , 文章类型: Article,,卷期:2008年26-4]
- The neurosphere assay can detect and expand neural stem cells (NSCs) and progenitor cells, but it cannot discriminate between these two populations. Given two assays have purported to overcome this shortfall, we performe...
- Enumeration of neural stem and progenitor cells in the neural colony-forming cell assay
[作者:Louis, SA; Rietze, RL; Deleyrolle, L; Wagey, RE; Thomas, TE; Eaves, AC; Reynolds, BA,期刊:Stem Cells, 页码:988-996 , 文章类型: Article,,卷期:2008年26-4]
- Advancement in our understanding of the biology of adult stem cells and their therapeutic potential relies heavily on meaningful functional assays that can identify and measure stem cell activity in vivo and in vitro. In...
- Lymphoid enhancer factor 1-mediated wnt signaling promotes the initiation of trophoblast lineage differentiation in mouse embryonic stem cells
[作者:He, SY; Pant, D; Schiffmacher, A; Meece, A; Keefer, CL,期刊:Stem Cells, 页码:842-849 , 文章类型: Article,,卷期:2008年26-4]
- Embryonic stem (ES) cells can differentiate into all three embryonic germ layers but rarely into trophectoderm (TE) lineages that contribute to the placenta, although TE differentiation can be initiated by genetic manipu...
- A key role for telomerase reverse transcriptase unit in modulating human embryonic stem cell proliferation, cell cycle dynamics, and in vitro differentiation
[作者:Yang, CB; Przyborski, S; Cooke, MJ; Zhang, X; Stewart, R; Anyfantis, G; Atkinson, SP; Saretzki, G; Armstrong, L; Lako, M,期刊:Stem Cells, 页码:850-863 , 文章类型: Article,,卷期:2008年26-4]
- Embryonic stem cells (ESC) are a unique cell population with the ability to self-renew and differentiate into all three germ layers. Human ESC express the telomerase reverse transcriptase (TERT) gene and the telomerase R...
- Comparison of reporter gene and iron particle labeling for tracking fate of human embryonic stem cells and differentiated endothelial cells in living subjects
[作者:Li, ZJ; Suzuki, Y; Huang, M; Cao, F; Xie, XY; Connolly, AJ; Yang, PC; Wu, JC,期刊:Stem Cells, 页码:864-873 , 文章类型: Article,,卷期:2008年26-4]
- Human embryonic stem (hES) cells are pluripotent stem cells capable of self-renewal and differentiation into virtually all cell types. Thus, they hold tremendous potential as cell sources for regenerative therapies. The ...
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