- Lentiviral-Mediated HoxB4 Expression in Human Embryonic Stem Cells Initiates Early Hematopoiesis in a Dose-Dependent Manner but Does Not Promote Myeloid Differentiation
[作者:Unger, C; Karner, E; Treschow, A; Stellan, B; Felldin, U; Concha, H; Wendel, M; Hovatta, O; Aints, A; Ahrlund-Richter, L; Dilber, MS,期刊:Stem Cells, 页码:2455-2466 , 文章类型: Article,,卷期:2008年26-10]
- The variation of HoxB4 expression levels might be a key regulatory mechanism in the differentiation of human embryonic stem cell (hESC)-derived hematopoietic stem cells (HSCs). In this study, hESCs ectopically expressing...
- Reprogramming of Neural Progenitor Cells into Induced Pluripotent Stem Cells in the Absence of Exogenous Sox2 Expression
[作者:Eminli, S; Utikal, J; Arnold, K; Jaenisch, R; Hochedlinger, K,期刊:Stem Cells, 页码:2467-2474 , 文章类型: Article,,卷期:2008年26-10]
- Expression of the transcription factors Oct4, Sox2, Klf4, and c-Myc in mesodermal and endodermal derivatives, including fibroblasts, lymphocytes, liver, stomach, and beta cells, generates induced pluripotent stem (iPS) c...
- OP9 Stroma Augments Survival of Hematopoietic Precursors and Progenitors During Hematopoietic Differentiation from Human Embryonic Stem Cells
[作者:Ji, JF; Vijayaragavan, K; Bosse, M; Weisel, K; Bhatia, M,期刊:Stem Cells, 页码:2485-2495 , 文章类型: Article,,卷期:2008年26-10]
- The cellular mechanism and target cell affected by stromal microenvironments in augmenting hematopoietic specification from pluripotent human embryonic stem cells (hESCs) has yet to be evaluated. Here, in contrast to aor...
- MicroRNA Discovery and Profiling in Human Embryonic Stem Cells by Deep Sequencing of Small RNA Libraries
[作者:Bar, M; Wyman, SK; Fritz, BR; Qi, JL; Garg, KS; Parkin, RK; Kroh, EM; Bendoraite, A; Mitchell, PS; Nelson, AM; Ruzzo, WL; Ware, C; Radich, JP; Gentleman, R; Ruohola-Baker, H; Tewari, M,期刊:Stem Cells, 页码:2496-2505 , 文章类型: Article,,卷期:2008年26-10]
- We used massively parallel pyrosequencing to discover and characterize microRNAs (miRNAs) expressed in human embryonic stem cells (hESC). Sequencing of small RNA cDNA libraries derived from undifferentiated hESC and from...
- A Stable Niche Supports Long-Term Maintenance of Human Epidermal Stem Cells in Organotypic Cultures
[作者:Muffler, S; Stark, HJ; Amoros, M; Falkowska-Hansen, B; Boehnke, K; Buhring, HJ; Marme, A; Bickenbach, JR; Boukamp, P,期刊:Stem Cells, 页码:2506-2515 , 文章类型: Article,,卷期:2008年26-10]
- Stem cells in human interfollicular epidermis are still difficult to identify, mainly because of a lack of definitive markers and the inability to label human beings for label-retaining cells (LRCs). Here, we report that...
- CD34+Testicular Stromal Cells Support Long-Term Expansion of Embryonic and Adult Stem and Progenitor Cells
[作者:Kim, J; Seandel, M; Falciatori, I; Wen, DC; Rafii, S,期刊:Stem Cells, 页码:2516-2522 , 文章类型: Article,,卷期:2008年26-10]
- Stem cells reside in specialized microenvironments created by supporting stromal cells that orchestrate self-renewal and lineage-specific differentiation. However, the precise identity of the cellular and molecular pathw...
- CD105-Positive Cells in Pulmonary Arterial Blood of Adult Human Lung Cancer Patients Include Mesenchymal Progenitors
[作者:Chiba, H; Ishii, G; Ito, TK; Aoyagi, K; Sasaki, H; Nagai, K; Ochiai, A,期刊:Stem Cells, 页码:2523-2530 , 文章类型: Article,,卷期:2008年26-10]
- Mesenchymal progenitor cells (MPCs) exhibit fibroblast-like morphology and are multipotent cells capable of differentiating into various mesenchymal tissues. Although MPCs have been found in adult bone marrow and umbilic...
- Mesenchymal Stem Cells Alter Migratory Property of T and Dendritic Cells to Delay the Development of Murine Lethal Acute Graft-Versus-Host Disease
[作者:Li, H; Guo, ZK; Jiang, XX; Zhu, H; Li, XS; Mao, N,期刊:Stem Cells, 页码:2531-2541 , 文章类型: Article,,卷期:2008年26-10]
- Due to the potent immunoregulatory capacity, mesenchymal stem cells (MSCs) have been used in clinical trials to treat acute graft-versus-host disease (aGvHD), although the detailed in vivo mechanisms remain elusive. In a...
- Migration of Neurotrophic Factors-Secreting Mesenchymal Stem Cells Toward a Quinolinic Acid Lesion as Viewed by Magnetic Resonance Imaging
[作者:Sadan, O; Shemesh, N; Barzilay, R; Bahat-Stromza, M; Melamed, E; Cohen, Y; Offen, D,期刊:Stem Cells, 页码:2542-2551 , 文章类型: Article,,卷期:2008年26-10]
- Stem cell-based treatment is a promising frontier for neurodegenerative diseases. We propose a novel protocol for inducing the differentiation of rat mesenchymal stem cells (MSCs) toward neurotrophic factor (NTF)-secreti...
- Directed Evolution of Motor Neurons from Genetically Engineered Neural Precursors
[作者:Bohl, D; Liu, S; Blanchard, S; Hocquemiller, M; Haase, G; Heard, JM,期刊:Stem Cells, 页码:2564-2575 , 文章类型: Article,,卷期:2008年26-10]
- Stem cell-based therapies hold therapeutic promise for degenerative motor neuron diseases, such as amyotrophic lateral sclerosis, and for spinal cord injury. Fetal neural progenitors present less risk of tumor formation ...
- Characterization of Side Population Cells from Human Airway Epithelium
[作者:Hackett, TL; Shaheen, F; Johnson, A; Wadsworth, S; Pechkovsky, DV; Jacoby, DB; Kicic, A; Stick, SM; Knight, DA,期刊:Stem Cells, 页码:2576-2585 , 文章类型: Article,,卷期:2008年26-10]
- The airway epithelium is the first line of contact with the inhaled external environment and is continuously exposed to and injured by pollutants, allergens, and viruses. However, little is known about epithelial repair ...
- Enhancing the Reliability and Throughput of Neurosphere Culture on Hydrogel Microwell Arrays
[作者:Cordey, M; Limacher, M; Kobel, S; Taylor, V; Lutolf, MP,期刊:Stem Cells, 页码:2586-2594 , 文章类型: Article,,卷期:2008年26-10]
- The neurosphere assay is the standard retrospective assay to test the self-renewal capability and multipotency of neural stem cells (NSCs) in vitro. However, it has recently become clear that not all neurospheres are der...
- Embryonic Stem Cell Therapy of Heart Failure in Genetic Cardiomyopathy
[作者:Yamada, S; Nelson, TJ; Crespo-Diaz, RJ; Perez-Terzic, C; Liu, XK; Miki, T; Seino, S; Behfar, A; Terzic, A,期刊:Stem Cells, 页码:2644-2653 , 文章类型: Article,,卷期:2008年26-10]
- Pathogenic causes underlying nonischemic cardiomyopathies are increasingly being resolved, yet repair therapies for these commonly heritable forms of heart failure are lacking. A case in point is human dilated cardiomyop...
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