- Brain Cancer Stem Cells Display Preferential Sensitivity to Akt Inhibition
[作者:Eyler, CE; Foo, WC; Lafiura, KM; McLendon, RE; Hjelmeland, AB; Rich, JN,期刊:Stem Cells, 页码:3027-3036 , 文章类型: Article,,卷期:2008年26-12]
- Malignant brain tumors are among the most lethal cancers, and conventional therapies are largely limited to palliation. Novel therapies targeted against specific molecular pathways may offer superior efficacy and less to...
- Human T-Cell Lymphotropic Virus Type 1 Infection of CD34(+) Hematopoietic Progenitor Cells Induces Cell Cycle Arrest by Modulation of p21(cip1/waf1) and Survivin
[作者:Banerjee, P; Sieburg, M; Samuelson, E; Feuer, G,期刊:Stem Cells, 页码:3047-3058 , 文章类型: Article,,卷期:2008年26-12]
- Human T-cell lymphotropic virus type 1 (HTLV-1) is an oncogenic retrovirus and the etiologic agent of adult T-cell leukemia (ATL), an aggressive CD4(+) malignancy. HTLV-2 is highly homologous to HTLV-1; however, infectio...
- Identification of a Small Subpopulation of Candidate Leukemia-Initiating Cells in the Side Population of Patients with Acute Myeloid Leukemia
[作者:Moshaver, B; van Rhenen, A; Kelder, A; van der Pol, M; Terwijn, M; Bachas, C; Westra, AH; Ossenkoppele, GJ; Zweegman, S; Schuurhuis, GJ,期刊:Stem Cells, 页码:3059-3067 , 文章类型: Article,,卷期:2008年26-12]
- In acute myeloid leukemia (AML), apart from the CD34(+)CD38(-) compartment, the side population (SP) compartment contains leukemic stem cells (LSCs). We have previously shown that CD34(+)CD38(-) LSCs can be identified us...
- OCT4 Spliced Variants Are Differentially Expressed in Human Pluripotent and Nonpluripotent Cells
[作者:Atlasi, Y; Mowla, SJ; Ziaee, SAM; Gokhale, PJ; Andrews, PW,期刊:Stem Cells, 页码:3068-3074 , 文章类型: Article,,卷期:2008年26-12]
- OCT4 is a master regulator of self-renewal in embryonic stem cells and can potentially encode two spliced variants, designated OCT4A and OCT4B. We have examined the expression pattern of these OCT4 isoforms in various hu...
- Isolation of Primordial Germ Cells from Differentiating Human Embryonic Stem Cells
[作者:Tilgner, K; Atkinson, SP; Golebiewska, A; Stojkovic, M; Lako, M; Armstrong, L,期刊:Stem Cells, 页码:3075-3085 , 文章类型: Article,,卷期:2008年26-12]
- Of all the cell types that can be obtained from the differentiation of embryonic stem cells, primordial germ cells are arguably the most fascinating, as they represent the in vitro completion of the reproductive cycle of...
- Spatiotemporal Recapitulation of Central Nervous System Development by Murine Embryonic Stem Cell-Derived Neural Stem/Progenitor Cells
[作者:Okada, Y; Matsumoto, A; Shimazaki, T; Enoki, R; Koizumi, A; Ishii, S; Itoyama, Y; Sobue, G; Okano, H,期刊:Stem Cells, 页码:3086-3098 , 文章类型: Article,,卷期:2008年26-12]
- Neural stem/progenitor cells (NS/PCs) can generate a wide variety of neural cells. However, their fates are generally restricted, depending on the time and location of NS/PC origin. Here we demonstrate that we can recapi...
- Secreted Proteoglycans Directly Mediate Human Embryonic Stem Cell-Basic Fibroblast Growth Factor 2 Interactions Critical for Proliferation
[作者:Levenstein, ME; Berggren, WT; Lee, JE; Conard, KR; Llanas, RA; Wagner, RJ; Smith, LM; Thomson, JA,期刊:Stem Cells, 页码:3099-3107 , 文章类型: Article,,卷期:2008年26-12]
- Human embryonic stem (ES) cells can be maintained in an undifferentiated state if the culture medium is first conditioned on a layer of mouse embryonic fibroblast (MEF) feeder cells. Here we show that human ES cell proli...
- A Developmentally Regulated Heparan Sulfate Epitope Defines a Subpopulation with Increased Blood Potential During Mesodermal Differentiation
[作者:Baldwin, RJ; ten Dam, GB; van Kuppevelt, TH; Lacaud, G; Gallagher, JT; Kouskoff, V; Merry, CLR,期刊:Stem Cells, 页码:3108-3118 , 文章类型: Article,,卷期:2008年26-12]
- Heparan sulfate (HS) is a mandatory coreceptor for many growth factors and morphogens involved in embryonic development; its bioactivity is dictated by complex sulfation motifs embedded within the polymer chain. Using a ...
- Herpes Simplex Virus-Mediated Expression of Pax3 and MyoD in Embryoid Bodies Results in Lineage-Related Alterations in Gene Expression Profiles
[作者:Craft, AM; Krisky, DM; Wechuck, JB; Lobenhofer, EK; Jiang, Y; Wolfe, DP; Glorioso, JC,期刊:Stem Cells, 页码:3119-3129 , 文章类型: Article,,卷期:2008年26-12]
- The ability of embryonic stem cells to develop into multiple cell lineages provides a powerful resource for tissue repair and regeneration. Gene transfer offers a means to dissect the complex events in lineage determinat...
- 1,4,5-Inositol Trisphosphate-Operated Intracellular Ca2+ Stores and Angiotensin-II/Endothelin-1 Signaling Pathway Are Functional in Human Embryonic Stem Cell-Derived Cardiomyocytes
[作者:Sedan, O; Dolnikov, K; Zeevi-Levin, N; Leibovich, N; Amit, M; Itskovitz-Eldor, J; Binah, O,期刊:Stem Cells, 页码:3130-3138 , 文章类型: Article,,卷期:2008年26-12]
- On the basis of previous findings suggesting that in human embryonic stem cell-derived cardiomyocytes (hESC-CM) the sarcoplasmic reticulum Ca2+-induced release of calcium machinery is either absent or immature, in the pr...
- Endogenous Matrix Metalloproteinase (MMP)-3 and MMP-9 Promote the Differentiation and Migration of Adult Neural Progenitor Cells in Response to Chemokines
[作者:Barkho, BZ; Munoz, AE; Li, XK; Li, L; Cunningham, LA; Zhao, XY,期刊:Stem Cells, 页码:3139-3149 , 文章类型: Article,,卷期:2008年26-12]
- Adult neurogenesis is regulated by both intrinsic programs and extrinsic stimuli. The enhanced proliferation of adult neural stem/progenitor cells (aNPCs) in the subventricular zone and the migration of neuroblasts towar...
- A Cross-Talk Between Stromal Cell-Derived Factor-1 and Transforming Growth Factor-beta Controls the Quiescence/Cycling Switch of CD34(+) Progenitors Through FoxO3 and Mammalian Target of Rapamycin
[作者:Chabanon, A; Desterke, C; Rodenburger, E; Clay, D; Guerton, B; Boutin, L; Bennaceur-Griscelli, A; Pierre-Louis, O; Uzan, G; Abecassis, L; Bourgeade, MF; Lataillade, JJ; Le Bousse-Kerdiles, MC,期刊:Stem Cells, 页码:3150-3161 , 文章类型: Article,,卷期:2008年26-12]
- Cell cycle regulation plays a fundamental role in stem cell biology. A balance between quiescence and proliferation of hematopoietic stem cells in interaction with the microenvironment is critical for sustaining long-ter...
- CD138/Syndecan-1 and SSEA-1 Mark Distinct Populations of Developing Ciliary Epithelium That Are Regulated Differentially by Wnt Signal
[作者:Koso, H; Iida, A; Tabata, Y; Baba, Y; Satoh, S; Taketo, MM; Watanabe, S,期刊:Stem Cells, 页码:3162-3171 , 文章类型: Article,,卷期:2008年26-12]
- Ciliary epithelium (CE), which consists of nonpigmented and pigmented layers, develops from the optic vesicle. However, the molecular mechanisms underlying CE development have not been closely examined, in part because c...
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