- 9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: Optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro
[作者:KRECMEROVA MARCELA; JANSA PETR; DRACINSKY MARTIN; SAZELOVA PETRA; KASICKA VACLAV; NEYTS JOHAN; AUWERX JOERI; KISS ELEONORA; GORIS NESYA; STEPAN GEORGE; JANEBA ZLATKO,期刊:Bioorganic & Medicinal Chemistry, 页码:1199-1208 , 文章类型: Article,,卷期:2013年21-5]
- New large-scale synthetic approach to antiretroviral agent 9-[2-(R)-(phosphonomethoxy) propyl]-2,6-diaminopurine, (R)-PMPDAP, was developed. Reaction of (R)-propanediol carbonate with 2,6-diaminopurine afforded exclusive...
- N-2-Trimethylacetyl substituted and unsubstituted-N-4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2 ,3-d]pyrimidine-2,4-diamines: Design, cellular receptor tyrosine kinase inhibitory activities and in vivo evaluation as antiangiogenic, antimetastatic and antitumor agents
[作者:GANGJEE ALEEM; NAMJOSHI OJAS A; YU JIANMING; IHNAT MICHAEL A; THORPE JESSICA E; BAILEYDOWNS LORA C,期刊:Bioorganic & Medicinal Chemistry, 页码:1312-1323 , 文章类型: Article,,卷期:2013年21-5]
- Six novel N-4-phenylsubstituted-6-(2-pyridin-2-ylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines and their N-2-trimethylacetyl substituted analogs were synthesized as receptor tyrosine kinase (RTK) inhibitors. A microwav...
- Naphthalenyl derivatives for hitting P-gp/MRP1/BCRP transporters
[作者:COLABUFO NICOLA A; CONTINO MARIALESSANDRA; CANTORE MARIANGELA; CAPPARELLI ELENA; PERRONE MARIA GRAZIA; CASSANO GIUSEPPE; GASPARRE GIUSEPPE; LEOPOLDO MARCELLO; BERARDI FRANCESCO; PERRONE ROBERTO,期刊:Bioorganic & Medicinal Chemistry, 页码:1324-1332 , 文章类型: Article,,卷期:2013年21-5]
- Substituted naphthalenyl derivatives bearing oxazole, or thiazole or furyl heteronuclei have been carried out as bioisosters of aryl-oxazoles and -thiazoles derivatives previously reported in order to investigate the rol...
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