- C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site
[作者:Ma, JH; Martin, JD; Xue, Y; Lor, LA; Kennedy-Wilson, KM; Sinnamon, RH; Ho, TF; Zhang, GF; Schwartz, B; Tummino, PJ; Lai, Z,期刊:Archives of Biochemistry and Biophysics , 页码:207-212 , 文章类型: Article,,卷期:2010年503-2]
- USP7, also known as the hepes simplex virus associated ubiquitin-specific protease (HAUSP), deubiquitinates both mdm2 and p53, and plays an important role in regulating the level and activity of p53. Here, we report that...
- Cell adhesive peptide screening of the mouse laminin alpha 1 chain G domain
[作者:Hozumi, K; Akizuki, T; Yamada, Y; Hara, T; Urushibata, S; Katagiri, F; Kikkawa, Y; Nomizu, M,期刊:Archives of Biochemistry and Biophysics , 页码:213-222 , 文章类型: Article,,卷期:2010年503-2]
- Cell adhesive peptides have been widely applied for therapeutic drugs, drug delivery systems, and biomaterials. Previously, we identified various cell adhesive sequences in the G domains of four laminin alpha chains (alp...
- Properties and tissue distribution of a novel aldo-keto reductase encoding in a rat gene (Akr1b10)
[作者:Endo, S; Matsunaga, T; Kuragano, T; Ohno, S; Kitade, Y; Tajima, K; El-Kabbani, O; Hara, A,期刊:Archives of Biochemistry and Biophysics , 页码:230-237 , 文章类型: Article,,卷期:2010年503-2]
- A recent rat genomic sequencing predicts a gene Akr1b10 that encodes a protein with 83% sequence similarity to human aldo-keto reductase (AKR) 1B10. In this study, we isolated the cDNA for the rat AKR1B10 (R1B10) from ra...
- Autoproteolysis of the SEA module of rMuc3 C-terminal domain modulates its functional composition
[作者:Peng, ZH; He, YH; Yang, YT; Zhu, R; Bai, JY; Li, YC; Yu, H; Zhang, X; Chen, L; Chen, WS; Fang, DC; Wang, R,期刊:Archives of Biochemistry and Biophysics , 页码:238-247 , 文章类型: Article,,卷期:2010年503-2]
- rMuc3 is a typical transmembrane mucin and contains a 174 amino acid domain called an SEA module in its C-terminal domain which is cleaved in eukaryotic cells. However, the mechanism by which the rMuc3 SEA module is prot...
- Metabolism of 4-hydroxy-2-nonenal in human polymorphonuclear leukocytes
[作者:Siems, W; Crifo, C; Capuozzo, E; Uchida, K; Grune, T; Salerno, C,期刊:Archives of Biochemistry and Biophysics , 页码:248-252 , 文章类型: Article,,卷期:2010年503-2]
- Intracellular metabolism of 4-hydroxy-2-nonenal (HNE), a major product and mediator of oxidative stress and inflammation, is analyzed in resting and fMLP-stimulated human polymorphonuclear leukocytes (PMNL), where this c...
- Molecular enzymology of lipoxygenases
[作者:Ivanov, I; Heydeck, D; Hofheinz, K; Roffeis, J; O'Donnell, VB; Kuhn, H; Walther, M,期刊:Archives of Biochemistry and Biophysics , 页码:161-174 , 文章类型: Review,,卷期:2010年503-2]
- Lipoxygenases (LOXs) are lipid peroxidizing enzymes, implicated in the pathogenesis of inflammatory and hyperproliferative diseases, which represent potential targets for pharmacological intervention. Although soybean LO...
- Expression, purification, stability optimization and characterization of human Aurora B kinase domain from E. coli
[作者:Sheth, PR; Ramanathan, L; Ranchod, A; Basso, AD; Barrett, D; Zhao, J; Gray, K; Liu, YH; Zhang, RM; Le, HV,期刊:Archives of Biochemistry and Biophysics , 页码:191-201 , 文章类型: Article,,卷期:2010年503-2]
- Aurora B kinase plays a critical role in regulating mitotic progression, and its dysregulation has been linked to tumorigenesis. The structure of the kinase domain of human Aurora B and the complementary information of b...
- Disruption of quaternary structure in Escherichia coli dihydrodipicolinate synthase (DHDPS) generates a functional monomer that is no longer inhibited by lysine
[作者:Muscroft-Taylor, AC; Catchpole, RJ; Dobson, RCJ; Pearce, FG; Perugini, MA; Gerrard, JA,期刊:Archives of Biochemistry and Biophysics , 页码:202-206 , 文章类型: Article,,卷期:2010年503-2]
- Escherichia coli dihydrodipicolinate synthase (DHDPS, E.C. 4.2.1.52), a natively homotetrameric enzyme was converted to a monomeric species through the introduction of destabilising interactions at two different subunit ...
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