- The kinetic mechanism of human uridine phosphorylase 1: Towards the development of enzyme inhibitors for cancer chemotherapy
[作者:Renck, D; Ducati, RG; Palma, MS; Santos, DS; Basso, LA,期刊:Archives of Biochemistry and Biophysics , 页码:35-42 , 文章类型: Article,,卷期:2010年497-1-2]
- Uridine phosphorylase (UP) is a key enzyme in the pyrimidine salvage pathway, catalyzing the reversible phosphorolysis of uridine to uracil and ribose-l-phosphate (R1P). The human UP type 1 (hUP1) is a molecular target f...
- Identification of biologically active sequences in the laminin alpha 2 chain G domain
[作者:Urushibata, S; Hozumi, K; Ishikawa, M; Katagiri, F; Kikkawa, Y; Nomizu, M,期刊:Archives of Biochemistry and Biophysics , 页码:43-54 , 文章类型: Article,,卷期:2010年497-1-2]
- Laminin alpha 2 chain is specifically expressed in the basement membrane surrounding muscle and nerve. We screened biologically active sequences in the mouse laminin alpha 2 chain G domain using 110 soluble peptides by t...
- Dose-dependent changes in cyclin D1 in response to 4-nitroquinoline 1-oxide-induced DNA damage
[作者:Suwaki, N; Child, ES; Elphick, LM; Mann, DJ,期刊:Archives of Biochemistry and Biophysics , 页码:55-61 , 文章类型: Article,,卷期:2010年497-1-2]
- Cells respond to DNA damage by either repairing the damage or committing to a death or senescence pathway, dependent on the level of damage sustained. In this study, we show that the protein levels of cyclin D1 and the C...
- Nanosecond pulsed electric fields stimulate apoptosis without release of pro-apoptotic factors from mitochondria in B16f10 melanoma
[作者:Ford, WE; Ren, W; Blackmore, PF; Schoenbach, KH; Beebe, SJ,期刊:Archives of Biochemistry and Biophysics , 页码:82-89 , 文章类型: Article,,卷期:2010年497-1-2]
- Nanosecond pulsed electric fields (nsPEFs) eliminates B16f10 melanoma in mice, but cell death mechanisms and kinetics of molecular events of cell death are not fully characterized. Treatment of B16f10 cells in vitro resu...
- The solubility of nucleobases in aqueous arginine solutions
[作者:Hirano, A; Tokunaga, H; Tokunaga, M; Arakawa, T; Shiraki, K,期刊:Archives of Biochemistry and Biophysics , 页码:90-96 , 文章类型: Article,,卷期:2010年497-1-2]
- Arginine is widely used in refolding, purification, analysis and formulation of proteins, primarily because of its ability to suppress protein-protein and protein-surface interactions. Such a property of arginine is at l...
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