- Rescuing of the hydride transfer reaction in the Glu312Asp variant of choline oxidase by a substrate analogue
[作者:Quaye, O; Nguyen, T; Gannavaram, S; Pennati, A; Gadda, G,期刊:Archives of Biochemistry and Biophysics , 页码:1-5 , 文章类型: Article,,卷期:2010年499-1-2]
- In the active site of choline oxidase, Glu312 participates in binding the trimethylammonium group of choline, thereby positioning the alcohol substrate properly for efficient hydride transfer to the enzyme-bound flavin. ...
- Structural changes associated with the acute thermal instability of Rubisco activase
[作者:Barta, C; Dunkle, AM; Wachter, RM; Salvucci, ME,期刊:Archives of Biochemistry and Biophysics , 页码:17-25 , 文章类型: Article,,卷期:2010年499-1-2]
- Inhibition of photosynthesis by heat has been linked to the instability of the ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) chaperone, Rubisco activase. Examination of the recombinant enzyme showed that ADP ...
- Specific molten globule conformation of stem bromelain at alkaline pH
[作者:Dave, S; Mahajan, S; Chandra, V; Dkhar, HK; Sambhavi; Gupta, P,期刊:Archives of Biochemistry and Biophysics , 页码:26-31 , 文章类型: Article,,卷期:2010年499-1-2]
- Stem bromelain (SBM), a therapeutic protein, is rapidly absorbed across the gut epithelium. Because SBM encounters an alkaline pH at its principal site of absorption, we investigated the alkaline-induced denaturation of ...
- Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions
[作者:Byun, S; Tortorella, MD; Malfait, AM; Fok, K; Frank, EH; Grodzinsky, AJ,期刊:Archives of Biochemistry and Biophysics , 页码:32-39 , 文章类型: Article,,卷期:2010年499-1-2]
- The availability of therapeutic molecules to targets within cartilage depends on transport through the avascular matrix. We studied equilibrium partitioning and non-equilibrium transport into cartilage of Pf-pep, a 760 D...
- HER2-mediated upregulation of MMP-1 is involved in gastric cancer cell invasion
[作者:Bao, W; Fu, HJ; Jia, LT; Zhang, Y; Li, W; Jin, BQ; Yao, LB; Chen, SY; Yang, AG,期刊:Archives of Biochemistry and Biophysics , 页码:49-55 , 文章类型: Article,,卷期:2010年499-1-2]
- HER2 overexpression is associated with metastasis the main cause of death in individuals with gastric cancer. In this study, we demonstrated that vector-based shRNA significantly knocked down the expression of HER2 and c...
- Lower succinyl-CoA:3-ketoacid-CoA transferase (SCOT) and ATP citrate lyase in pancreatic islets of a rat model of type 2 diabetes: Knockdown of SCOT inhibits insulin release in rat insulinoma cells
[作者:Hasan, NM; Longacre, MJ; Ahmed, MS; Kendrick, MA; Gu, H; Ostenson, CG; Fukao, T; MacDonald, MJ,期刊:Archives of Biochemistry and Biophysics , 页码:62-68 , 文章类型: Article,,卷期:2010年499-1-2]
- Succinyl-CoA:3-ketoacid-CoA transferase (SCOT) is a mitochondrial enzyme that catalyzes the reversible transfer of coenzyme-A from acetoacetyl-CoA to succinate to form acetoacetate and succinyl-CoA. mRNAs of SCOT and ATP...
- Identification of pregnancy-associated CA125-reactive protein as a carbohydrate-binding immunoglobulin G
[作者:Milutinovic, B; Mitic, N; Jankovic, M,期刊:Archives of Biochemistry and Biophysics , 页码:69-76 , 文章类型: Article,,卷期:2010年499-1-2]
- Cancer antigen 125 (CA125), also referred to as mucin 16, is expressed under both normal and pathological conditions and the complexity of its structure indicates multifunctionality, i.e. both the protein and carbohydrat...
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