- ER beta Impedes Prostate Cancer EMT by Destabilizing HIF-1 alpha and Inhibiting VEGF-Mediated Snail Nuclear Localization: Implications for Gleason Grading
[作者：Mak, P; Leav, I; Pursell, B; Bae, D; Yang, XF; Taglienti, CA; Gouvin, LM; Sharma, VM; Mercurio, AM,期刊：Cancer Cell, 页码：319-332 , 文章类型： Article，,卷期：2010年17-4]
- High Gleason grade prostate carcinomas are aggressive, poorly differentiated tumors that exhibit diminished estrogen receptor beta (ER beta) expression. We report that a key function of ER beta and its specific ligand 5 ...
- Sp1/NF kappa B/HDAC/miR-29b Regulatory Network in KIT-Driven Myeloid Leukemia
[作者：Liu, SJ; Wu, LC; Pang, JX; Santhanam, R; Schwind, S; Wu, YZ; Hickey, CJ; Yu, JH; Becker, H; Maharry, K; Radmacher, MD; Li, CL; Whitman, SP; Mishra, A; Stauffer, N; Eiring, AM; Briesewitz, R; Baiocchi, RA; Chan, KK; Paschka, P; Caligiuri, MA; Byrd, JC; Croce, CM; Bloomfield, CD; Perrotti, D; Garzon, R; Marcucci, G,期刊：Cancer Cell, 页码：333-347 , 文章类型： Article，,卷期：2010年17-4]
- The biologic and clinical significance of KIT overexpression that associates with KIT gain-of-function mutations occurring in subsets of acute myeloid leukemia (AML) (i.e., core binding factor AML) is unknown. Here, we s...
- A Transcriptional Signature and Common Gene Networks Link Cancer with Lipid Metabolism and Diverse Human Diseases
[作者：Hirsch, HA; Iliopoulos, D; Joshi, A; Zhang, Y; Jaeger, SA; Bulyk, M; Tsichlis, PN; Liu, XS; Struhl, K,期刊：Cancer Cell, 页码：348-361 , 文章类型： Article，,卷期：2010年17-4]
- Transcriptional profiling of two isogenic models of transformation identifies a gene signature linking cancer with inflammatory and metabolic diseases. In accord with this common transcriptional program, many drugs used ...
- A Hierarchy of Self-Renewing Tumor-Initiating Cell Types in Glioblastoma
[作者：Chen, RH; Nishimura, MC; Bumbaca, SM; Kharbanda, S; Forrest, WF; Kasman, IM; Greve, JM; Soriano, RH; Gilmour, LL; Rivers, CS; Modrusan, Z; Nacu, S; Guerrero, S; Edgar, KA; Wallin, JJ; Lamszus, K; Westphal, M; Heim, S; James, CD; VandenBerg, SR; Costello, JF; Moorefield, S; Cowdrey, CJ; Prados, M; Phillips, HS,期刊：Cancer Cell, 页码：362-375 , 文章类型： Article，,卷期：2010年17-4]
- The neural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133(-) cells exhibiting similar properties have ...
- Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence
[作者：Chicas, A; Wang, XW; Zhang, CL; McCurrach, M; Zhao, Z; Mert, O; Dickins, RA; Narita, M; Zhang, M; Lowe, SW,期刊：Cancer Cell, 页码：376-387 , 文章类型： Article，,卷期：2010年17-4]
- The RB protein family (RB, p107, and p130) has overlapping and compensatory functions in cell-cycle control. However, cancer-associated mutations are almost exclusively found in RB, implying that RB has a nonredundant ro...
- Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
[作者：Kim, J; Tang, JY; Gong, RY; Kim, J; Lee, JJ; Clemons, KV; Chong, CR; Chang, KS; Fereshteh, M; Gardner, D; Reya, T; Liu, JO; Epstein, EH; Stevens, DA; Beachy, PA,期刊：Cancer Cell, 页码：388-399 , 文章类型： Article，,卷期：2010年17-4]
- In a screen of drugs previously tested in humans we identified itraconazole, a systemic antifungal, as a potent antagonist of the Hedgehog (Hh) signaling pathway that acts by a mechanism distinct from its inhibitory effe...
- A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo
[作者：Cerchietti, LC; Ghetu, AF; Zhu, X; Da Silva, GF; Zhong, SJ; Matthews, M; Bunting, KL; Polo, JM; Fares, C; Arrowsmith, CH; Yang, SN; Garcia, M; Coop, A; MacKerell, AD; Prive, GG; Melnick, A,期刊：Cancer Cell, 页码：400-411 , 文章类型： Article，,卷期：2010年17-4]
- The BCL6 transcriptional repressor is the most frequently involved oncogene in diffuse large B cell lymphoma (DLBCL). We combined computer-aided drug design with functional assays to identify low-molecular-weight compoun...
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