- Regression of Castrate-Recurrent Prostate Cancer by a Small-Molecule Inhibitor of the Amino-Terminus Domain of the Androgen Receptor
[作者：Andersen, RJ; Mawji, NR; Wang, J; Wang, G; Haile, S; Myung, JK; Watt, K; Tam, T; Yang, YC; Banuelos, CA; Williams, DE; McEwan, IJ; Wang, YZ; Sadar, MD,期刊：Cancer Cell, 页码：535-546 , 文章类型： Article，,卷期：2010年17-6]
- Castration-recurrent prostate cancer (CRPC) is suspected to depend on androgen receptor (AR). The AF-1 region in the amino-terminal domain (NTD) of AR contains most, if not all, of the transcriptional activity. Here we i...
- Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors
[作者：Carretero, J; Shimamura, T; Rikova, K; Jackson, AL; Wilkerson, MD; Borgman, CL; Buttarazzi, MS; Sanofsky, BA; McNamara, KL; Brandstetter, KA; Walton, ZE; Gu, TL; Silva, JC; Crosby, K; Shapiro, GI; Maira, SM; Ji, HB; Castrillon, DH; Kim, CF; Garcia-Echeverria, C; Bardeesy, N; Sharpless, NE; Hayes, ND; Kim, WY; Engelman, JA; Wong, KK,期刊：Cancer Cell, 页码：547-559 , 文章类型： Article，,卷期：2010年17-6]
- In mice, Lkb1 deletion and activation of KraS(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomi...
- NSAID Sulindac and Its Analog Bind RXR alpha and Inhibit RXR alpha-Dependent AKT Signaling
[作者：Zhou, H; Liu, W; Su, Y; Wei, Z; Liu, J; Kolluri, SK; Wu, H; Cao, Y; Chen, JB; Wu, Y; Yan, TD; Cao, XH; Gao, WW; Molotkov, A; Jiang, FQ; Li, WG; Lin, BZ; Zhang, HP; Yu, JH; Luo, SP; Zeng, JZ; Duester, G; Huang, PQ; Zhang, XK,期刊：Cancer Cell, 页码：560-573 , 文章类型： Article，,卷期：2010年17-6]
- Nonsteroidal anti-inflammatory drugs (NSAIDs) exert their anticancer effects through cyclooxygenase-2 (COX-2)-dependent and independent mechanisms. Here, we report that Sulindac, an NSAID, induces apoptosis by binding to...
- Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells
[作者：Mullally, A; Lane, SW; Ball, B; Megerdichian, C; Okabe, R; Al-Shahrour, F; Paktinat, M; Haydu, JE; Housman, E; Lord, AM; Wernig, G; Kharas, MG; Mercher, T; Kutok, JL; Gilliland, DG; Ebert, BL,期刊：Cancer Cell, 页码：584-596 , 文章类型： Article，,卷期：2010年17-6]
- We report a Jak2V617F knockin mouse myeloproliferative neoplasm (MPN) model resembling human polycythemia vera (PV). The MPN is serially transplantable and we demonstrate that the hematopoietic stem cell (HSC) compartmen...
- GSK-3 Promotes Conditional Association of CREB and Its Coactivators with MEIS1 to Facilitate HOX-Mediated Transcription and Oncogenesis
[作者：Wang, Z; Iwasaki, M; Ficara, F; Lin, CW; Matheny, C; Wong, SHK; Smith, KS; Cleary, ML,期刊：Cancer Cell, 页码：597-608 , 文章类型： Article，,卷期：2010年17-6]
- Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. We demonstrate here that GSK-3 maintain...
- The PAF Complex Synergizes with MLL Fusion Proteins at HOX Loci to Promote Leukemogenesis
[作者：Muntean, AG; Tan, JY; Sitwala, K; Huang, YS; Bronstein, J; Connelly, JA; Basrur, V; Elenitoba-Johnson, KSJ; Hess, JL,期刊：Cancer Cell, 页码：609-621 , 文章类型： Article，,卷期：2010年17-6]
- MLL is involved in chromosomal rearrangements that generate fusion proteins with deregulated transcriptional activity. The mechanisms of MLL fusion protein-mediated transcriptional activation are poorly understood. Here ...
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