- Integrative Genomic Profiling of Human Prostate Cancer
[作者：Taylor, BS; Schultz, N; Hieronymus, H; Gopalan, A; Xiao, YH; Carver, BS; Arora, VK; Kaushik, P; Cerami, E; Reva, B; Antipin, Y; Mitsiades, N; Landers, T; Dolgalev, I; Major, JE; Wilson, M; Socci, ND; Lash, AE; Heguy, A; Eastham, JA; Scher, HI; Reuter, VE; Scardino, PT; Sander, C; Sawyers, CL; Gerald, WL,期刊：Cancer Cell, 页码：11-22 , 文章类型： Article，,卷期：2010年18-1]
- Annotation of prostate cancer genomes provides a foundation for discoveries that can impact disease understanding and treatment. Concordant assessment of DNA copy number, m RNA expression, and focused exon resequencing i...
- Siah2-Dependent Concerted Activity of HIF and FoxA2 Regulates Formation of Neuroendocrine Phenotype and Neuroendocrine Prostate Tumors
[作者：Qi, JF; Nakayama, K; Cardiff, RD; Borowsky, AD; Kaul, K; Williams, R; Krajewski, S; Mercola, D; Carpenter, PM; Bowtell, D; Ronai, ZA,期刊：Cancer Cell, 页码：23-38 , 文章类型： Article，,卷期：2010年18-1]
- Neuroendocrine (NE) phenotype, seen in >30% of prostate adenocarcinomas (PCa), and NE prostate tumors are implicated in aggressive prostate cancer. Formation of NE prostate tumors in the TRAMP mouse model was suppressed ...
- 4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors
[作者：She, QB; Halilovic, E; Ye, Q; Zhen, W; Shirasawa, S; Sasazuki, T; Solit, DB; Rosen, N,期刊：Cancer Cell, 页码：39-51 , 文章类型： Article，,卷期：2010年18-1]
- PIK3CA and PTEN alterations are common in human cancer, but only a fraction of such tumors are dependent upon AKT signaling. AKT independence is associated with redundant activation of cap-dependent translation mediated ...
- PCBP1 Suppresses the Translation of Metastasis-Associated PRL-3 Phosphatase
[作者：Wang, HH; Vardy, LA; Tan, CP; Loo, JM; Guo, K; Li, J; Lim, SG; Zhou, JB; Chng, WJ; Ng, SB; Li, HX; Zeng, Q,期刊：Cancer Cell, 页码：52-62 , 文章类型： Article，,卷期：2010年18-1]
- Overexpression of phosphatase of regenerating liver (PRL)-3 is associated with the progression of diverse human cancers. We show that the overexpression of PRL-3 protein is not directly associated with its transcript lev...
- A Synthetic Lethal Interaction between K-Ras Oncogenes and Cdk4 Unveils a Therapeutic Strategy for Non-small Cell Lung Carcinoma
[作者：Puyol, M; Martin, A; Dubus, P; Mulero, F; Pizcueta, P; Khan, G; Guerra, C; Santamaria, D; Barbacid, M,期刊：Cancer Cell, 页码：63-73 , 文章类型： Article，,卷期：2010年18-1]
- We have unveiled a synthetic lethal interaction between K-Ras oncogenes and Cdk4 in a mouse tumor model that closely recapitulates human non-small cell lung carcinoma (NSCLC). Ablation of Cdk4, but not Cdk2 or Cdk6, indu...
- Wnt/Ca2+/NFAT Signaling Maintains Survival of Ph+ Leukemia Cells upon Inhibition of Bcr-Abl
[作者：Gregory, MA; Phang, TL; Neviani, P; Alvarez-Calderon, F; Eide, CA; O'Hare, T; Zaberezhnyy, V; Williams, RT; Druker, BJ; Perrotti, D; DeGregori, J,期刊：Cancer Cell, 页码：74-87 , 文章类型： Article，,卷期：2010年18-1]
- Although Bcr-Abl kinase inhibitors have proven effective in the treatment of chronic myeloid leukemia (CML), they generally fail to eradicate Bcr-Abl(+) leukemia cells. To identify genes whose inhibition sensitizes Bcr-A...
- PML/RARA Oxidation and Arsenic Binding Initiate the Antileukemia Response of As2O3
[作者：Jeanne, M; Lallemand-Breitenbach, V; Ferhi, O; Koken, M; Le Bras, M; Duffort, S; Peres, L; Berthier, C; Soilihi, H; Raught, B; de The, H,期刊：Cancer Cell, 页码：88-98 , 文章类型： Article，,卷期：2010年18-1]
- As2O3 cures acute promyelocytic leukemia (APL) by initiating PML/RARA oncoprotein degradation, through sumoylation of its PML moiety. However, how As2O3 initiates PML sumoylation has remained largely unexplained. As2O3 b...
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