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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共16条记录   Cancer Cell of Origin: Spotlight on Luminal Progenitors [作者：Chaffer, CL; Weinberg, RA,期刊：Cell Stem Cell, 页码：271-272 , 文章类型： Editorial Material，,卷期：2010年7-3] Does basal type breast cancer arise from oncogenic transformation of a basal cell type? In this issue of Cell Stem Cell, Molyneux et al. (2010) investigate the provenance of the basal-type BRCA1 breast carcinoma and come... Microarraying for Mechanosensivitity [作者：Schaffer, DV,期刊：Cell Stem Cell, 页码：273-274 , 文章类型： Editorial Material，,卷期：2010年7-3] In a recent issue of Science, Gilbert et al. combine biomaterial microarrays with lineage tracking to demonstrate that muscle stem cell survival is sensitive to the microenvironment's mechanical stiffness (Gilbert et al.... The STATs on Naive iPSC Reprogramming [作者：Hanna, JH,期刊：Cell Stem Cell, 页码：274-276 , 文章类型： Editorial Material，,卷期：2010年7-3] Pluripotency can be induced in somatic cells via ectopic expression of defined transcription factors. In this issue of Cell Stem Cell, Yang et al. (2010) demonstrate that Lif/Stat3 signaling directly contributes to the i... Hypoxia Signaling in Hematopoietic Stem Cells: A Double-Edged Sword [作者：Pollard, PJ; Kranc, KR,期刊：Cell Stem Cell, 页码：276-278 , 文章类型： Editorial Material，,卷期：2010年7-3] Although hematopoietic stem cells (HSCs) reside in hypoxic niches, the significance of hypoxia signaling in HSCs remains unclear. In this issue of Cell Stem Cell, Takubo et al. (2010) and Simsek et al. (2010) demonstrate... Tumor-Initiating Cells Are Rare in Many Human Tumors [作者：Ishizawa, K; Rasheed, ZA; Karisch, R; Wang, QJ; Kowalski, J; Susky, E; Pereira, K; Karamboulas, C; Moghal, N; Rajeshkumar, NV; Hidalgo, M; Tsao, M; Ailles, L; Waddell, TK; Maitra, A; Neel, BG; Matsui, W,期刊：Cell Stem Cell, 页码：279-282 , 文章类型： Article，,卷期：2010年7-3] The Orphan Drug Act and the Development of Stem Cell-Based Products for Rare Diseases [作者：Freeman, SN; Burke, KA; Imoisili, MA; Cote, TR,期刊：Cell Stem Cell, 页码：283-287 , 文章类型： Editorial Material，,卷期：2010年7-3] The Orphan Drug Act encourages the development of products for rare diseases and conditions. Many conditions that stand to benefit from stem cell-based products are rare diseases. We address the Orphan Drug Act in relati... Polycomb Group Proteins Set the Stage for Early Lineage Commitment [作者：Surface, LE; Thornton, SR; Boyer, LA,期刊：Cell Stem Cell, 页码：288-298 , 文章类型： Review，,卷期：2010年7-3] Precise control of gene expression patterns is critical for the specification of cellular diversity during metazoan development. Polycomb group (PcG) proteins comprise a class of transcriptional modifiers that have dynam... Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer [作者：Sauvageau, M; Sauvageau, G,期刊：Cell Stem Cell, 页码：299-313 , 文章类型： Review，,卷期：2010年7-3] Polycomb Group (PcG) proteins are transcriptional repressors that epigenetically modify chromatin and participate in the establishment and maintenance of cell fates. These proteins play important roles in both stem cell ... Stat3 Activation Is Limiting for Reprogramming to Ground State Pluripotency [作者：Yang, JA; van Oosten, AL; Theunissen, TW; Guo, G; Silva, JCR; Smith, A,期刊：Cell Stem Cell, 页码：319-328 , 文章类型： Article，,卷期：2010年7-3] The cytokine leukemia inhibitory factor (Lif) sustains self-renewal of mouse embryonic and induced pluripotent stem cells by activating Jak kinase and the transcription factor Stat3. Here we investigate whether Jak/Stat3... Female Human iPSCs Retain an Inactive X Chromosome [作者：Tchieu, J; Kuoy, E; Chin, MH; Trinh, H; Patterson, M; Sherman, SP; Aimiuwu, O; Lindgren, A; Hakimian, S; Zack, JA; Clark, AT; Pyle, AD; Lowry, WE; Plath, K,期刊：Cell Stem Cell, 页码：329-342 , 文章类型： Article，,卷期：2010年7-3] Generating induced pluripotent stem cells (iPSCs) requires massive epigenome reorganization. It is unclear whether reprogramming of female human cells reactivates the inactive X chromosome (Xi), as in mouse. Here we esta... Myc Represses Primitive Endoderm Differentiation in Pluripotent Stem Cells [作者：Smith, KN; Singh, AM; Dalton, S,期刊：Cell Stem Cell, 页码：343-354 , 文章类型： Article，,卷期：2010年7-3] The generation of induced pluripotent stem cells (iPSCs) provides a novel method to facilitate investigations into the mechanisms that control stem cell pluripotency and self-renewal. Myc has previously been shown to be ... Functional Diversity of ESC-Derived Motor Neuron Subtypes Revealed through Intraspinal Transplantation [作者：Peljto, M; Dasen, JS; Mazzoni, EO; Jessell, TM; Wichterle, H,期刊：Cell Stem Cell, 页码：355-366 , 文章类型： Article，,卷期：2010年7-3] Cultured ESCs can form different classes of neurons, but whether these neurons can acquire specialized subtype features typical of neurons in vivo remains unclear. We show here that mouse ESCs can be directed to form hig... Regulated Segregation of Kinase Dyrk1A during Asymmetric Neural Stem Cell Division Is Critical for EGFR-Mediated Biased Signaling [作者：Ferron, SR; Pozo, N; Laguna, A; Aranda, S; Porlan, E; Moreno, M; Fillat, C; de la Luna, S; Sanchez, P; Arbones, ML; Farinas, I,期刊：Cell Stem Cell, 页码：367-379 , 文章类型： Article，,卷期：2010年7-3] Stem cell division can result in two sibling cells exhibiting differential mitogenic and self-renewing potential. Here, we present evidence that the dual-specificity kinase Dyrk1A is part of a molecular pathway involved ... The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche [作者：Simsek, T; Kocabas, F; Zheng, JK; DeBerardinis, RJ; Mahmoud, AI; Olson, EN; Schneider, JW; Zhang, CC; Sadek, HA,期刊：Cell Stem Cell, 页码：380-390 , 文章类型： Article，,卷期：2010年7-3] Bone marrow transplantation is the primary therapy for numerous hematopoietic disorders. The efficiency of bone marrow transplantation depends on the function of long-term hematopoietic stem cells (LT-HSCs), which is mar... Regulation of the HIF-1 alpha Level Is Essential for Hematopoietic Stem Cells [作者：Takubo, K; Goda, N; Yamada, W; Iriuchishima, H; Ikeda, E; Kubota, Y; Shima, H; Johnson, RS; Hirao, A; Suematsu, M; Suda, T,期刊：Cell Stem Cell, 页码：391-402 , 文章类型： Article，,卷期：2010年7-3] Hematopoietic stem cells (HSCs) are sustained in a specific microenvironment known as the stem cell niche. Mammalian HSCs are kept quiescent in the endosteal niche, a hypoxic zone of the bone marrow (BM). In this study, ... BRCA1 Basal-like Breast Cancers Originate from Luminal Epithelial Progenitors and Not from Basal Stem Cells [作者：Molyneux, G; Geyer, FC; Magnay, FA; McCarthy, A; Kendrick, H; Natrajan, R; MacKay, A; Grigoriadis, A; Tutt, A; Ashworth, A; Reis, JS; Smalley, MJ,期刊：Cell Stem Cell, 页码：403-417 , 文章类型： Article，,卷期：2010年7-3] Breast cancers in BRCA1 mutation carriers frequently have a distinctive basal-like phenotype. It has been suggested that this results from an origin in basal breast epithelial stem cells. Here, we demonstrate that deleti...