- Benefits of Utilizing Gene-Modified iPSCs for Clinical Applications
[作者:Ellis, J; Baum, C; Benvenisty, N; Mostoslavsky, G; Okano, H; Stanford, WL; Porteus, M; Sadelain, M,期刊:Cell Stem Cell, 页码:429-430 , 文章类型: Letter,,卷期:2010年7-4]
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- TNF/p38 alpha/Polycomb Signaling to Pax7 Locus in Satellite Cells Links Inflammation to the Epigenetic Control of Muscle Regeneration
[作者:Palacios, D; Mozzetta, C; Consalvi, S; Caretti, G; Saccone, V; Proserpio, V; Marquez, VE; Valente, S; Mai, A; Forcales, SV; Sartorelli, V; Puri, PL,期刊:Cell Stem Cell, 页码:455-469 , 文章类型: Article,,卷期:2010年7-4]
- How regeneration cues are converted into the epigenetic information that controls gene expression in adult stem cells is currently unknown. We identified an inflammation-activated signaling in muscle stem (satellite) cel...
- Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
[作者:Barnabe-Heider, F; Goritz, C; Sabelstrom, H; Takebayashi, H; Pfrieger, FW; Meletis, K; Frisen, J,期刊:Cell Stem Cell, 页码:470-482 , 文章类型: Article,,卷期:2010年7-4]
- Several distinct cell types in the adult central nervous system have been suggested to act as stem or progenitor cells generating new cells under physiological or pathological conditions. We have assessed the origin of n...
- Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis
[作者:Sierra, A; Encinas, JM; Deudero, JJP; Chancey, JH; Enikolopov, G; Overstreet-Wadiche, LS; Tsirka, SE; Maletic-Savatic, M,期刊:Cell Stem Cell, 页码:483-495 , 文章类型: Article,,卷期:2010年7-4]
- In the adult hippocampus, neuroprogenitor cells in the subgranular zone (SGZ) of the dentate gyrus give rise to newborn neuroblasts. However, only a small subset of these cells integrates into the hippocampal circuitry a...
- Early B Cell Factor 2 Regulates Hematopoietic Stem Cell Homeostasis in a Cell-Nonautonomous Manner
[作者:Kieslinger, M; Hiechinger, S; Dobreva, G; Consalez, GG; Grosschedl, R,期刊:Cell Stem Cell, 页码:496-507 , 文章类型: Article,,卷期:2010年7-4]
- Hematopoiesis requires the interaction of hematopoietic stem cells (HSCs) with various stromal microenvironments. Here, we examine the role of early B cell factor 2 (Ebf2), a transcription factor expressed in a subset of...
- Apoptotic Caspases Regulate Induction of iPSCs from Human Fibroblasts
[作者:Li, F; He, ZM; Shen, JP; Huang, QA; Li, WR; Liu, XJ; He, YJ; Wolf, F; Li, CY,期刊:Cell Stem Cell, 页码:508-520 , 文章类型: Article,,卷期:2010年7-4]
- The molecular mechanisms involved in the derivation of induced pluripotent stem cells (iPSCs) from differentiated cells are poorly understood. Here we report that caspases 3 and 8, two proteases associated with apoptotic...
- Identification and Classification of Chromosomal Aberrations in Human Induced Pluripotent Stem Cells
[作者:Mayshar, Y; Ben-David, U; Lavon, N; Biancotti, JC; Yakir, B; Clark, AT; Plath, K; Lowry, WE; Benvenisty, N,期刊:Cell Stem Cell, 页码:521-531 , 文章类型: Article,,卷期:2010年7-4]
- Because of their somatic cell origin, human induced pluripotent stem cells (HiPSCs) are assumed to carry a normal diploid genome, and adaptive chromosomal aberrations have not been fully evaluated. Here, we analyzed the ...
- Combinatorial Transcriptional Control In Blood Stem/Progenitor Cells: Genome-wide Analysis of Ten Major Transcriptional Regulators
[作者:Wilson, NK; Foster, SD; Wang, XN; Knezevic, K; Schutte, J; Kainnakis, P; Chilarska, PM; Kinston, S; Ouwehand, WH; Dzierzak, E; Pimanda, JE; de Bruijn, MFTR; Gottgens, B,期刊:Cell Stem Cell, 页码:532-544 , 文章类型: Article,,卷期:2010年7-4]
- Combinatorial transcription factor (TF) interactions control cellular phenotypes and, therefore, underpin stem cell formation, maintenance, and differentiation. Here, we report the genome-wide binding patterns and combin...
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