- Endothelial-Specific Expression of WNK1 Kinase Is Essential for Angiogenesis and Heart Development in Mice
[作者:Xie, J; Wu, T; Xu, K; Huang, IK; Cleaver, O; Huang, CL,期刊:American Journal of Pathology, 页码:1315-1327 , 文章类型: Article,,卷期:2009年175-3]
- WNK1 [with-no-lysine (K)-1] is a ubiquitous serine/threonine kinase with a unique placement of the catalytic lysine residue. Increased WNK1 expression levels in humans causes a hypertension-hyperkalemia syndrome by alter...
- Hypercholesterolemic Mice Exhibit Lymphatic Vessel Dysfunction and Degeneration
[作者:Lim, HY; Rutkowski, JM; Helft, J; Reddy, ST; Swartz, MA; Randolph, GJ; Angeli, V,期刊:American Journal of Pathology, 页码:1328-1337 , 文章类型: Article,,卷期:2009年175-3]
- Lymphatic vessels are essential for lipid absorption and transport. Despite increasing numbers of observations linking lymphatic vessels and lipids, little research has been devoted to address how dysregulation of lipid ...
- Mitochondrial (Dys)function in Adipocyte (De)differentiation and Systemic Metabolic Alterations
[作者:De Pauw, A; Tejerina, S; Raes, M; Keijer, J; Arnould, T,期刊:American Journal of Pathology, 页码:927-939 , 文章类型: Review,,卷期:2009年175-3]
- In mammals, adipose tissue, composed of BAT and WAT, collaborates in energy partitioning and performs metabolic regulatory functions. it is the most flexible tissue in the body, because it is remodeled in size and shape ...
- Tissue Inhibitor of Metalloproteinase-4 Is Elevated in Early-Stage Breast Cancers with Accelerated Progression and Poor Clinical Course
[作者:Liss, M; Sreedhar, N; Keshgegian, A; Sauter, G; Chernick, MR; Prendergast, GC; Wallon, UM,期刊:American Journal of Pathology, 页码:940-946 , 文章类型: Article,,卷期:2009年175-3]
- An increasing number of breast cancer patients are diagnosed with small, localized, early-stage tumors. These patients are typically thought to have a good prognosis for long-term disease-free survival, but epidemiologic...
- Characterization of RAGE, HMGB1, and S100 beta in Inflammation-Induced Preterm Birth and Fetal Tissue Injury
[作者:Buhimschi, CS; Baumbusch, MA; Dulay, AT; Oliver, EA; Lee, S; Zhao, GM; Bhandari, V; Ehrenkranz, RA; Weiner, CP; Madri, JA; Buhimschi, IA,期刊:American Journal of Pathology, 页码:958-975 , 文章类型: Article,,卷期:2009年175-3]
- Immune activation represents an adaptive reaction triggered by both noxious exogenous (microbes) and endogenous [high mobility group box-1 protein (HMGB1), S100 calcium binding proteins] inducers of inflammation. Cell st...
- Relationships between Deficits in Tissue Mass and Transcriptional Programs after Partial Hepatectomy in Mice
[作者:Li, JN; Campbell, JS; Mitchell, C; McMahan, RS; Yu, XS; Riehle, KJ; Bumgarner, RE; Fausto, N,期刊:American Journal of Pathology, 页码:947-957 , 文章类型: Article,,卷期:2009年175-3]
- Liver regeneration after two-thirds partial hepatectomy (2/3 PH) results in synchronized proliferation of hepatocytes and rapid restoration of liver mass. Understanding the mechanisms that regulate this process has both ...
- Netrin-1 Overexpression Protects Kidney from Ischemia Reperfusion Injury by Suppressing Apoptosis
[作者:Wang, WW; Reeves, WB; Pays, L; Mehlen, P; Ramesh, G,期刊:American Journal of Pathology, 页码:1010-1018 , 文章类型: Article,,卷期:2009年175-3]
- Netrin-1, a diffusible laminin-related protein, is highly expressed in the kidney. However, the pathophysiological roles of netrin-1 in the kidney are unknown. To address this question directly, we used transgenic mice t...
- Overexpression of MHC Class I Heavy Chain Protein in Young Skeletal Muscle Leads to Severe Myositis Implications for Juvenile Myositis
[作者:Li, CKC; Knopp, P; Moncrieffe, H; Singh, B; Shah, S; Nagaraju, K; Varsani, H; Gao, B; Wedderburn, LR,期刊:American Journal of Pathology, 页码:1030-1040 , 文章类型: Article,,卷期:2009年175-3]
- Folding and transport of proteins, such as major histocompatibitity complex (MHC) class 1, through the endoplasmic reticulum (ER) is tightly regulated in all cells, including muscle tissue, where the specialized ER sarco...
- The BH3-Only Protein Bid Does Not Mediate Death-Receptor-Induced Liver Injury in Obstructive Cholestasis
[作者:Nalapareddy, PD; Schungel, S; Hong, JY; Manns, MP; Jaeschke, H; Vogel, A,期刊:American Journal of Pathology, 页码:1077-1085 , 文章类型: Article,,卷期:2009年175-3]
- The accumulation of bile acids during obstructive cholestasis causes liver injury and fibrosis, which is at least partly mediated by the death receptors Tumor necrosis factor-related apoptosis-inducing ligand, Tumor necr...
- Essential Roles for Early Growth Response Transcription Factor Egr-1 in Tissue Fibrosis and Wound Healing
[作者:Wu, MH; Melichian, DS; de la Garza, M; Gruner, K; Bhattacharyya, S; Barr, L; Nair, A; Shahrara, S; Sporn, PHS; Mustoe, TA; Tourtellotte, WG; Varga, J,期刊:American Journal of Pathology, 页码:1041-1055 , 文章类型: Article,,卷期:2009年175-3]
- The early growth response gene (Egr-1) codes for a zinc finger transcription factor that has important roles in the regulation of cell growth, differentiation, and survival. Aberrant Egr-1 expression is implicated in car...
- Alteration of Tight Junction Proteins Is an Early Event in Psoriasis Putative Involvement of Proinflammatory Cytokines
[作者:Kirschner, N; Poetzl, C; von den Driesch, PV; Wladykowski, E; Moll, I; Behne, MJ; Brandner, JM,期刊:American Journal of Pathology, 页码:1095-1106 , 文章类型: Article,,卷期:2009年175-3]
- Psoriasis is an inflammatory skin disease characterized by hyperproliferation of keratinocytes, impaired barrier function, and pronounced infiltration of inflammatory cells. Tight junctions (TJs) are cell-cell junctions ...
- Sjogren's Syndrome-Like Ocular Surface Disease in Thrombospondin-1 Deficient Mice
[作者:Turpie, B; Yoshimura, T; Gulati, A; Rios, JD; Dartt, DA; Masli, S,期刊:American Journal of Pathology, 页码:1136-1147 , 文章类型: Article,,卷期:2009年175-3]
- Thrombospondin-1 (TSP-1) is a major activator of latent transforming growth factor-beta in vitro as well as in vivo. Mice deficient in TSP-1, despite appearing normal at birth, develop a chronic form of ocular surface di...
- Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 Modulates Experimental Autoimmune Encephalomyelitis via an iNKT Cell-Dependent Mechanism
[作者:Fujita, M; Otsuka, T; Mizuno, M; Tomi, C; Yamamura, T; Miyake, S,期刊:American Journal of Pathology, 页码:1116-1123 , 文章类型: Article,,卷期:2009年175-3]
- Carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) is a CEA family member that has been reported to have an important role in the regulation of Th1-mediated colitis. In this study, we examined the ro...
- Human Immunodeficiency Virus (HIV) Infection of Human Macrophages Is Increased by Dopamine A Bridge between HIV-Associated Neurologic Disorders and Drug Abuse
[作者:Gaskill, PJ; Calderon, TM; Luers, AJ; Eugenin, EA; Javitch, JA; Berman, JW,期刊:American Journal of Pathology, 页码:1148-1159 , 文章类型: Article,,卷期:2009年175-3]
- The prevalence of human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) that result from HIV infection of the central nervous system is increasing. Macrophages, the primary target for HIV within t...
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