- DOCK2 Is a Microglial Specific Regulator of Central Nervous System Innate Immunity Found in Normal and Alzheimer's Disease Brain
[作者:Cimino, PJ; Sokal, I; Leverenz, J; Fukui, Y; Montine, TJ,期刊:American Journal of Pathology, 页码:1622-1630 , 文章类型: Article,,卷期:2009年175-4]
- Neuroinflammation is a hallmark of several neurodegenerative diseases, including Alzheimer's disease (AD). Strong epidemiological and experimental evidence supports the use of nonsteroidal anti-inflammatory drugs to redu...
- HMGA1 Is Induced by Wnt/beta-Catenin Pathway and Maintains Cell Proliferation in Gastric Cancer
[作者:Akaboshi, S; Watanabe, S; Hino, Y; Sekita, Y; Xi, Y; Araki, K; Yamamura, K; Oshima, M; Ito, T; Baba, H; Nakao, M,期刊:American Journal of Pathology, 页码:1675-1685 , 文章类型: Article,,卷期:2009年175-4]
- The development of stomach cancer is closely associated with chronic inflammation, and the Wnt/beta-catenin signaling pathway is activated in most cases of this cancer. High-mobility group A (HMGA) proteins are oncogenic...
- Platelet-Derived Growth Factor Receptor Expression and Activation in Choroid Plexus Tumors
[作者:Koos, B; Paulsson, J; Jarvius, M; Sanchez, BC; Wrede, B; Mertsch, S; Jeibmann, A; Kruse, A; Peters, O; Wolff, JEA; Galla, HJ; Soderberg, O; Paulus, W; Ostman, A; Hasselblatt, M,期刊:American Journal of Pathology, 页码:1631-1637 , 文章类型: Article,,卷期:2009年175-4]
- Choroid plexus tumors are intraventricular neoplasms predominantly affecting young children. in contrast to choroid plexus papillomas, choroid plexus carcinomas progress frequently, necessitating the development of adjuv...
- Alterations in Aortic Cellular Constituents during Thoracic Aortic Aneurysm Development Myofibroblast-Mediated Vascular Remodeling
[作者:Jones, JA; Beck, C; Barbour, JR; Zavadzkas, JA; Mukherjee, R; Spinale, FG; Ikonomidis, JS,期刊:American Journal of Pathology, 页码:1746-1756 , 文章类型: Article,,卷期:2009年175-4]
- The present study tested the hypothesis that changes in the resident endogenous cellular population accompany alterations in aortic collagen and elastin content during thoracic aortic aneurysm (TAA) development in a muri...
- Advanced Glycation End Product Receptor-1 Transgenic Mice Are Resistant to Inflammation, Oxidative Stress, and Post-Injury Intimal Hyperplasia
[作者:Torreggiani, M; Liu, HX; Wu, J; Zheng, F; Cai, WJ; Striker, G; Vlassara, H,期刊:American Journal of Pathology, 页码:1722-1732 , 文章类型: Article,,卷期:2009年175-4]
- The high levels of oxidative stress (OS) and inflammation associated with cardiovascular disease are linked to pro-oxidants such as advanced glycation end products (AGEs). AGEs interact with multiple receptors, including...
- An Induction in Hepatic HDL Secretion Associated with Reduced ATPase Expression
[作者:Pandey, NR; Renwick, J; Rabaa, S; Misquith, A; Kouri, L; Twomey, E; Sparks, DL,期刊:American Journal of Pathology, 页码:1777-1787 , 文章类型: Article,,卷期:2009年175-4]
- Linoleic acid-phospholipids stimulate high-density lipoprotein (HDL) net secretion from liver cells by blocking the endocytic recycling of apoA-I. Experiments were undertaken to determine whether apoA-I accumulation in t...
- Decay-Accelerating Factor Suppresses Complement C3 Activation and Retards Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice
[作者:Leung, VWY; Yun, S; Botto, M; Mason, JC; Malik, TH; Song, WC; Paixao-Cavalcante, D; Pickering, MC; Boyle, JJ; Haskard, DO,期刊:American Journal of Pathology, 页码:1757-1767 , 文章类型: Article,,卷期:2009年175-4]
- Decay-accelerating factor (DAF; CD55) is a membrane protein that regulates complement pathway activity at the level of Q. To test the hypothesis that DAF plays an essential role in limiting complement activation in the a...
- Vascular Endothelial Growth Factors C and D Induces Proliferation of Lymphangioleiomyomatosis Cells through Autocrine Crosstalk with Endothelium
[作者:Issaka, RB; Oommen, S; Gupta, SK; Liu, G; Myers, JL; Ryu, JH; Vlahakis, NE,期刊:American Journal of Pathology, 页码:1410-1420 , 文章类型: Article,,卷期:2009年175-4]
- Lymphangioleiomyomatosis (LAM) is a potentially fatal lung disease characterized by nodules of proliferative smooth muscle-tike cells. The exact nature of these LAM cells and their proliferative stimuli are poorly charac...
- Calcification Locates to Transglutaminases in Advanced Human Atherosclerotic Lesions
[作者:Matlung, HL; Groen, HC; de Vos, J; van Walsum, T; van der Lugt, A; Niessen, WJ; Wentzel, JJ; Vanbavel, E; Bakker, ENTP,期刊:American Journal of Pathology, 页码:1374-1379 , 文章类型: Article,,卷期:2009年175-4]
- Transglutaminases play an important role in vascular smooth muscle cell-induced calcification in vitro. In this study, we determined whether these enzymes are also involved in human atherosclerotic calcification using ni...
- Kindlin-1 Is Required for RhoGTPase-Mediated Lamellipodia Formation in Keratinocytes
[作者:Has, C; Herz, C; Zimina, E; Qu, HY; He, YH; Zhang, ZG; Wen, TT; Gache, Y; Aumailley, M; Bruckner-Tuderman, L,期刊:American Journal of Pathology, 页码:1442-1452 , 文章类型: Article,,卷期:2009年175-4]
- Kindlin-1 is an epithelial-specific member of the novel kindlin protein family, which are regulators of integrin functions. Mutations in the gene that encodes Kindlin-1, FERMT1 (KIND1), cause the Kindler syndrome (KS), a...
- Nitric Oxide Induces the Progression of Abdominal Aortic Aneurysms through the Matrix Metalloproteinase Inducer EMMPRIN
[作者:Lizarbe, TR; Tarin, C; Gomez, M; Lavin, B; Aracil, E; Orte, LM; Zaragoza, C,期刊:American Journal of Pathology, 页码:1421-1430 , 文章类型: Article,,卷期:2009年175-4]
- Nitric Oxide (NO) is involved in the development and progression of abdominal aortic aneurysms (AAA). We found that inhibition of inducible NO synthase (iNOS) protects mice in an elastase-induced AAA model, significantly...
- Involvement of Sphingosine 1-Phosphate (SIP)/S1P(3) Signaling in Cholestasis-Induced Liver Fibrosis
[作者:Li, CY; Jiang, XM; Yang, L; Liu, XH; Yue, S; Li, LY,期刊:American Journal of Pathology, 页码:1464-1472 , 文章类型: Article,,卷期:2009年175-4]
- Bioactive sphingosine 1-phosphate (SIP) and S1P receptors (S1PRs) have been implicated in many critical cellular events, including inflammation, cancer, and angiogenesis. However, the role of S1P/S1PR signaling in the pa...
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