- Diabetic Albuminuria Is Due to a Small Fraction of Nephrons Distinguished by Albumin-Stained Tubules and Glomerular Adhesions
[作者:Kralik, PM; Long, YS; Song, Y; Yang, L; Wei, HY; Coventry, S; Zheng, SR; Epstein, PN,期刊:American Journal of Pathology, 页码:500-509 , 文章类型: Article,,卷期:2009年175-2]
- OVE26 diabetic mice develop severe albuminuria. Immunohistochemical analysis revealed a pattern of intense albumin staining in a small subset of OVE26 tubules. Immunostaining was strikingly heterogeneous; some tubules st...
- Differential Interferon Responses Enhance Viral Epitope Generation by Myocardial Immunoproteasomes in Murine Enterovirus Myocarditis
[作者:Jakel, S; Kuckelkorn, U; Szalay, G; Plotz, M; Textoris-Taube, K; Opitz, E; Klingel, K; Stevanovic, S; Kandolf, R; Kotsch, K; Stangl, K; Kloetzel, PM; Voigt, A,期刊:American Journal of Pathology, 页码:510-518 , 文章类型: Article,,卷期:2009年175-2]
- Murine models of coxsackievirus B3 (CVB3)-induced myocarditis mimic the divergent human disease course of cardiotropic viral infection, with host-specific outcomes ranging from complete recovery in resistant mice to chro...
- Activation of mTORC1 Signaling Pathway in AIDS-Related Lymphomas
[作者:El-Salem, M; Raghunath, PN; Marzec, M; Liu, XB; Kasprzycka, M; Robertson, E; Wasik, MA,期刊:American Journal of Pathology, 页码:817-824 , 文章类型: Article,,卷期:2009年175-2]
- Using inummohistochemistry with antibodies against the phosphoserine residues in both S6rp and 4E binding protein 1, we identified the activation of the mammalian target of rapamycin (mTORC)1 pathway in 29 cases of AIDS-...
- IL-21 Contributes to JAK3/STAT3 Activation and Promotes Cell Growth in ALK-Positive Anaplastic Large Cell Lymphoma
[作者:Bard, JD; Gelebart, P; Anand, M; Zak, Z; Hegazy, SA; Amin, HM; Lai, R,期刊:American Journal of Pathology, 页码:825-834 , 文章类型: Article,,卷期:2009年175-2]
- Interleukin (IL)-21 has been reported to both stimulate cell growth and promote survival in benign lymphoid cells and several types of hematopoietic neoplasms. It induces JAK3/STAT3 signaling, a biologically important ce...
- Overexpression of HO-1 Protects against TNF-alpha-Mediated Airway Inflammation by Down-Regulation of TNFR1-Dependent Oxidative Stress
[作者:Lee, IT; Luo, SF; Lee, CW; Wang, SW; Lin, CC; Chang, CC; Chen, YL; Chau, LY; Yang, CM,期刊:American Journal of Pathology, 页码:519-532 , 文章类型: Article,,卷期:2009年175-2]
- Oxidative stresses are believed to play an important role in the induction of both cell adhesion molecules and pro-inflammatory cytokines, a key event in a variety of Inflammatory processes. The enzyme heme oxygenase-1 (...
- Development of Arterial Blood Supply in Experimental Liver Metastases
[作者:Dezso, K; Bugyik, E; Papp, V; Laszlo, V; Dome, B; Tovari, J; Timar, J; Nagy, P; Paku, S,期刊:American Journal of Pathology, 页码:835-843 , 文章类型: Article,,卷期:2009年175-2]
- In this study, we present a mechanism for the development of arterial blood supply in experimental liver metastases. To analyze the arterialization process of experimental liver metastases, we elucidated a few key questi...
- MMP-13 Plays a Role in Keratinocyte Migration, Angiogenesis, and Contraction in Mouse Skin Wound Healing
[作者:Hattori, N; Mochizuki, S; Kishi, K; Nakajima, T; Takaishi, H; D'Armiento, J; Okada, Y,期刊:American Journal of Pathology, 页码:533-546 , 文章类型: Article,,卷期:2009年175-2]
- Matrix metalloproteinases (MMPs) have been implicated in wound healing. To analyze the roles of MMP-9 and MMP-13 in wound healing, we generated full-thickness cutaneous wounds in MMP-9 knockout (KO), MMP-13 KO, MMP-9/13 ...
- Macrophages Are Alternatively Activated in Patients with Endometriosis and Required for Growth and Vascularization of Lesions in a Mouse Model of Disease
[作者:Bacci, M; Capobianco, A; Monno, A; Cottone, L; Di Puppo, F; Camisa, B; Mariani, M; Brignole, C; Ponzoni, M; Ferrari, S; Panina-Bordignon, P; Manfredi, AA; Rovere-Querini, P,期刊:American Journal of Pathology, 页码:547-556 , 文章类型: Article,,卷期:2009年175-2]
- The mechanisms that sustain endometrial tissues at ectopic sites in patients with endometriosis are poorly understood. Various leukocytes, including macrophages, infiltrate endometriotic lesions. in this study, we deplet...
- Expression of Integrin alpha 6 beta 1 Enhances Tumorigenesis in Glioma Cells
[作者:Delamarre, E; Taboubi, S; Mathieu, S; Berenguer, C; Rigot, V; Lissitzky, JC; Figarella-Branger, D; Ouafik, L; Luis, J,期刊:American Journal of Pathology, 页码:844-855 , 文章类型: Article,,卷期:2009年175-2]
- The integrin alpha 6 beta 1 and its main ligand laminin-111 are overexpressed in glioblastoma, as compared with normal brain tissue, suggesting they may be involved in glioblastoma malignancy. To address this question, w...
- MYCN Promotes the Expansion of Phox2B-Positive Neuronal Progenitors to Drive Neuroblastoma Development
[作者:Alam, G; Cui, HJ; Shi, HL; Yang, LQ; Ding, J; Mao, L; Maltese, WA; Ding, HF,期刊:American Journal of Pathology, 页码:856-866 , 文章类型: Article,,卷期:2009年175-2]
- Amplification of the oncogene MYCN is a tumorigenic event in the development of a subset of neuroblastomas that commonly consist of undifferentiated or poorly differentiated neuroblasts; with unfavorable clinical outcome...
- ICAM-1 Is Necessary for Epithelial Recruitment of gamma delta T Cells and Efficient Corneal Wound Healing
[作者:Byeseda, SE; Burns, AR; Dieffenbaugher, S; Rumbaut, RE; Smith, CW; Li, ZJ,期刊:American Journal of Pathology, 页码:571-579 , 文章类型: Article,,卷期:2009年175-2]
- Wound healing and inflammation are both significantly reduced in mice that lack gamma delta T cells. Here, the role of epithelial intercellular adhesion molecule-1 (ICAM-1) in gamma delta T cell migration in corneal woun...
- Down-Regulation of DUSP6 Expression in Lung Cancer Its Mechanism and Potential Role in Carcinogenesis
[作者:Okudela, K; Yazawa, T; Woo, T; Sakaeda, M; Ishii, J; Mitsui, H; Shimoyamada, H; Sato, H; Tajiri, M; Ogawa, N; Masuda, M; Takahashi, T; Sugimura, H; Kitamura, H,期刊:American Journal of Pathology, 页码:867-881 , 文章类型: Article,,卷期:2009年175-2]
- Our preliminary studies revealed that oncogenic ICRAS (KRAS/V12) dramatically suppressed the growth of immoritalized airway epithelial cells (NHBE-T, with viral antigen-inactivated P53 and RB proteins). This process appe...
- Suppressive Roles of Calreticulin in Prostate Cancer Growth and Metastasis
[作者:Alur, M; Nguyen, MM; Eggener, SE; Jiang, F; Dadras, SS; Stern, J; Kimm, S; Roehl, K; Kozlowski, J; Pins, M; Michalak, M; Dhir, R; Wang, Z,期刊:American Journal of Pathology, 页码:882-890 , 文章类型: Article,,卷期:2009年175-2]
- Calreticulin is an essential, multifunctional Ca2+-binding protein that participates in the regulation of intracellular Ca2+ homeostasis, cell adhesion, and chaperoning. Calreticulin is abundantly expressed and regulated...
- Disruption of E-Cadherin by Matrix Metalloproteinase Directly Mediates Epithelial-Mesenchymal Transition Downstream of Transforming Growth Factor-beta 1 in Renal Tubular Epithelial Cells
[作者:Zheng, GP; Lyons, JG; Tan, TK; Wang, YP; Hsu, TT; Min, DQ; Succar, L; Rangan, GK; Hu, M; Henderson, BR; Alexander, SI; Harris, DCH,期刊:American Journal of Pathology, 页码:580-591 , 文章类型: Article,,卷期:2009年175-2]
- Epithelial-mesenchymal transition (EMT) plays an important role in organ fibrosis, including that of the kidney. Loss of E-cadherin expression is a hallmark of EMT; however, whether the loss of E-cadherin is a consequenc...
- Matrilysin-1 Mediates Bronchiolization of Alveoli, a Potential Premalignant Change in Lung Cancer
[作者:Wang, XY; Demelash, A; Kim, H; Jensen-Taubman, S; Dakir, EH; Ozbun, L; Birrer, MJ; Linnoila, RI,期刊:American Journal of Pathology, 页码:592-604 , 文章类型: Article,,卷期:2009年175-2]
- Matrilysin-1 (also called matrix metalloproteinase-7) is expressed in injured lung and in cancer but not in normal epithelia. Bronchiolization of the alveoli (BOA), a potential precursor of lung cancer, is a histological...
|