- TIMP-3: A novel target for glucocorticoid signaling at the blood-brain barrier
[作者:Hartmann, C; El-Gindi, J; Lohmann, C; Lischpler, M; Zeni, P; Galla, HJ,期刊:Biochemical and Biophysical Research Communications, 页码:182-186 , 文章类型: Article,,卷期:2009年390-2]
- Glucocorticoids (GCs) are used in the treatment of neuroinflammatory diseases such as multiple sclerosis. Several studies have demonstrated the beneficial effect of GCs on the balance between matrix metalloproteinases (M...
- FRET-based kinetic analysis of highly reactive heterochiral DNA toward EcoRI endonuclease
[作者:Urata, H; Tamaki, C; Matsuno, M; Wada, S; Akagi, M,期刊:Biochemical and Biophysical Research Communications, 页码:192-195 , 文章类型: Article,,卷期:2009年390-2]
- We found unusual reactivity of a heterochiral dodecadeoxynucleotide toward EcoRI that contains an unnatural L-nucleotide residue at the 3'-flanking site of the hexameric EcoRI recognition sequence. In this study, the kin...
- Early growth response-1 is involved in foam cell formation and is upregulated by the TLR9-MyD88-ERK1/2 pathway
[作者:Kim, JS; Park, DW; Lee, HK; Kim, JR; Baek, SH,期刊:Biochemical and Biophysical Research Communications, 页码:196-200 , 文章类型: Article,,卷期:2009年390-2]
- Early growth response-1 (Egr-1), a zinc finger transcription factor, plays a key regulatory role in pathological cardiovascular processes including atherosclerosis. Here, we investigate whether Egr-1 expression and foam ...
- The LIM domain protein Wtip interacts with the receptor tyrosine kinase Ror2 and inhibits canonical Wnt signalling
[作者:van Wijk, NV; Witte, F; Feike, AC; Schambony, A; Birchmeier, W; Mundlos, S; Stricker, S,期刊:Biochemical and Biophysical Research Communications, 页码:211-216 , 文章类型: Article,,卷期:2009年390-2]
- Wtip is a LIM domain Protein of the Ajuba/Zyxin family involved in kidney and neural crest development; Ror2 is a receptor tyrosine kinase involved in the development of skeleton, heart, lung, genitalia and kidneys. Here...
- RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation
[作者:Ruan, YY; Guo, L; Qiao, Y; Hong, Y; Zhou, L; Sun, LL; Wang, LJ; Zhu, HY; Wang, L; Yun, XJ; Xie, JH; Gu, JX,期刊:Biochemical and Biophysical Research Communications, 页码:217-222 , 文章类型: Article,,卷期:2009年390-2]
- CLEC-2 is a C-type lectin-like receptor and plays an important role in platelet activation. Snake venom toxin rhodocytin and the endogenous sialoglycoprotein podoplanin are identified as ligands for CLEC-2 and function a...
- The bHLH transcription factor Hand2 regulates the expression of nanog in ANS differentiation
[作者:Hashimoto, Y; Myojin, R; Katoh, N; Ohtsu, M; Tashiro, F; Onoda, F; Murakami, Y,期刊:Biochemical and Biophysical Research Communications, 页码:223-229 , 文章类型: Article,,卷期:2009年390-2]
- The basic helix-loop-helix transcription factor Hand2 is induced by bone morphogenetic proteins (BMPs) in neural crest-derived precursor cells during the early stage of development of the autonomic nervous system (ANS). ...
- Transport of hypoxia-inducible factor HIF-1 alpha into the nucleus involves importins 4 and 7
[作者:Chachami, G; Paraskeva, E; Mingot, JM; Braliou, GG; Gorlich, D; Simos, G,期刊:Biochemical and Biophysical Research Communications, 页码:235-240 , 文章类型: Article,,卷期:2009年390-2]
- Hypoxia-inducible transcription factor 1 (HIF-1) mediates the cellular response to hypoxia. HIF-1 activity is controlled via the synthesis, degradation or intracellular localization of its alpha subunit. HIF-1 alpha cont...
- Redox regulation of transcriptional activity of retinoic acid receptor by thioredoxin glutathione reductase (TGR)
[作者:Park, UH; Han, HS; Um, E; An, XH; Kim, EJ; Um, SJ,期刊:Biochemical and Biophysical Research Communications, 页码:241-246 , 文章类型: Article,,卷期:2009年390-2]
- The retinoic acid receptor (RAR), as one of the retinoic acid (RA)-responsive transcription activators, mediates various biological processes by regulating RA target gene expression. In studying how RAR activity is regul...
- microRNA miR-27b impairs human adipocyte differentiation and targets PPAR gamma
[作者:Karbiener, M; Fischer, C; Nowitsch, S; Opriessnig, P; Papak, C; Ailhaud, G; Dani, C; Amri, EZ; Scheideler, M,期刊:Biochemical and Biophysical Research Communications, 页码:247-251 , 文章类型: Article,,卷期:2009年390-2]
- Obesity has emerged as a global health problem with more than 1.1 billion adults to be classified as overweight or obese, and is associated with type 2 diabetes, cardiovascular disease, and several cancers. Since obesity...
- beta-Catenin/TCF/LEF1 can directly regulate phenylephrine-induced cell hypertrophy and Anf transcription in cardiomyocytes
[作者:Zhang, CG; Jia, ZQ; Li, BH; Zhang, H; Liu, YN; Chen, P; Ma, KT; Zhou, CY,期刊:Biochemical and Biophysical Research Communications, 页码:258-262 , 文章类型: Article,,卷期:2009年390-2]
- beta-Catenin/TCF/LEF1 signaling is implicated in cardiac hypertrophy. We demonstrate that knockdown of beta-catenin attenuates phenylephrine (PE)-induced cardiomyocyte hypertrophy and the up-regulation of the fetal gene ...
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