- Conserved aspartic acid residues lining the extracellular loop I of sodium-coupled bile acid transporter ASBT interact with Na+ and 7 alpha-OH moieties on the ligand cholestane skeleton
[作者:Hussainzada, N; Da Silva, TC; Zhang, EY; Swaan, PW,期刊:Journal of Biological Chemistry, 页码:20653-20663 , 文章类型: Article,,卷期:2008年283-30]
- Functional contributions of residues Val-99-Ser-126 lining extracellular loop (EL) 1 of the apical sodium-dependent bile acid transporter were determined via cysteine-scanning mutagenesis, thiol modification, and in sili...
- Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase
[作者:Kang, NJ; Lee, KW; Lee, DE; Rogozin, EA; Bode, AM; Lee, HJ; Dong, ZG,期刊:Journal of Biological Chemistry, 页码:20664-20673 , 文章类型: Article,,卷期:2008年283-30]
- Cocoa was shown to inhibit chemically induced carcinogenesis in animals and exert antioxidant activity in humans. However, the molecular mechanisms of the chemopreventive potential of cocoa and its active ingredient(s) r...
- The PIM1 kinase is a critical component of a survival pathway activated by docetaxel and promotes survival of docetaxel-treated prostate cancer cells
[作者:Zemskova, M; Sahakian, E; Bashkirova, S; Lilly, M,期刊:Journal of Biological Chemistry, 页码:20635-20644 , 文章类型: Article,,卷期:2008年283-30]
- A defining characteristic of solid tumors is the capacity to divide aggressively and disseminate under conditions of nutrient deprivation, limited oxygen availability, and exposure to cytotoxic drugs or radiation. Surviv...
- Modification of Drosophila p53 by SUMO modulates its transactivation and pro-apoptotic functions
[作者:Mauri, F; McNamee, LM; Lunardi, A; Chiacchiera, F; Del Sal, G; Brodsky, MH; Collavin, L,期刊:Journal of Biological Chemistry, 页码:20848-20856 , 文章类型: Article,,卷期:2008年283-30]
- Conjugation to SUMO is a reversible post-translational modification that regulates several transcription factors involved in cell proliferation, differentiation, and disease. The p53 tumor suppressor can be modified by S...
- Modulation of voltage- and Ca2+-dependent gating of Ca(v)1.3 L-type calcium channels by alternative splicing of a C-terminal regulatory domain
[作者:Singh, A; Gebhart, M; Fritsch, R; Sinnegger-Brauns, MJ; Poggiani, C; Hoda, JC; Engel, J; Romanin, C; Striessnig, J; Koschak, A,期刊:Journal of Biological Chemistry, 页码:20733-20744 , 文章类型: Article,,卷期:2008年283-30]
- Low voltage activation of Ca(V)1.3 L-type Ca2+ channels controls excitability in sensory cells and central neurons as well as sinoatrial node pacemaking. Ca(V)1.3-mediated pacemaking determines neuronal vulnerability of ...
- Multiple intrinsically disordered sequences alter DNA binding by the homeodomain of the Drosophila Hox protein Ultrabithorax
[作者:Liu, Y; Matthews, KS; Bondos, SE,期刊:Journal of Biological Chemistry, 页码:20874-20887 , 文章类型: Article,,卷期:2008年283-30]
- During animal development, distinct tissues, organs, and appendages are specified through differential gene transcription by Hox transcription factors. However, the conserved Hox homeodomains bind DNA with high affinity ...
- Functional and structural characterization of a cation-dependent O-methyltransferase from the cyanobacterium Synechocystis sp strain PCC 6803
[作者:Kopycki, JG; Stubbs, MT; Brandt, W; Hagemann, M; Porzel, A; Schmidt, J; Schliemann, W; Zenk, MH; Vogt, T,期刊:Journal of Biological Chemistry, 页码:20888-20896 , 文章类型: Article,,卷期:2008年283-30]
- The coding sequence of the cyanobacterium Synechocystis sp. strain PCC 6803 slr0095 gene was cloned and functionally expressed in Escherichia coli. The corresponding enzyme was classified as a cation- and S-adenosyl-L-me...
- Oxidative inactivation of the proteasome in retinal pigment epithelial cells - A potential link between oxidative stress and up-regulation of interleukin-8
[作者:Fernandes, AF; Zhou, JL; Zhang, XY; Bian, QN; Sparrow, J; Taylor, A; Pereira, P; Shang, F,期刊:Journal of Biological Chemistry, 页码:20745-20753 , 文章类型: Article,,卷期:2008年283-30]
Oxidative stress and inflammation are implicated in the pathogenesis of many age-related diseases. Stress-induced overproduction of inflammatory cytokines, such as interleukin-8 (IL-8), is one of the early events of i...
- Phosphorylation of bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1
[作者:Deng, HB; Yu, F; Chen, JQ; Zhao, YM; Xiang, JL; Lin, AN,期刊:Journal of Biological Chemistry, 页码:20754-20760 , 文章类型: Article,,卷期:2008年283-30]
- The mitogen-activated protein kinase JNK1 suppresses interleukin-3 withdrawal-induced cell death through phosphorylation of the BH3-only pro-apoptotic Bcl-2 family protein Bad at Thr-201. It is unknown whether JNK1 regul...
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