- Anticancer drugs up-regulate HspBP1 and thereby antagonize the prosurvival function of hsp70 in tumor cells
[作者:Tanimura, S; Hirano, AI; Hashizume, J; Yasunaga, M; Kawabata, T; Ozaki, KI; Kohno, M,期刊:Journal of Biological Chemistry, 页码:35430-35439 , 文章类型: Article,,卷期:2007年282-49]
- The 70-kDa heat shock protein (Hsp70) is up-regulated in a wide variety of tumor cell types and contributes to the resistance of these cells to the induction of cell death by anticancer drugs. Hsp70 binding protein 1 (Hs...
- The role of the fibronectin IGD motif in stimulating fibroblast migration
[作者:Millard, CJ; Ellis, IR; Pickford, AR; Schor, AM; Schor, SL; Campbell, ID,期刊:Journal of Biological Chemistry, 页码:35530-35535 , 文章类型: Article,,卷期:2007年282-49]
- The motogenic activity of migration-stimulating factor, a truncated isoform of fibronectin (FN), has been attributed to the IGD motifs present in its FN type 1 modules. The structure-function relationship of various reco...
- Calcium-activated (p)ppGpp synthetase in chloroplasts of land plants
[作者:Tozawa, Y; Nozawa, A; Kanno, T; Narisawa, T; Masuda, S; Kasai, K; Nanamiya, H,期刊:Journal of Biological Chemistry, 页码:35536-35545 , 文章类型: Article,,卷期:2007年282-49]
- The genetic system of chloroplasts, including the machinery for transcription, translation, and DNA replication, exhibits substantial similarity to that of eubacteria. Chloroplasts are also thought to possess a system fo...
- Kinetics of the interactions between yeast elongation factors 1A and 1B alpha, guanine nucleotides, and aminoacyl-tRNA
[作者:Gromadski, KB; Schummer, T; Stromgaard, A; Knudsen, CR; Kinzy, TG; Rodnina, MV,期刊:Journal of Biological Chemistry, 页码:35629-35637 , 文章类型: Article,,卷期:2007年282-49]
- The interactions of elongation factor 1A (eEF1A) from Saccharomyces cerevisiae with elongation factor 1B alpha (eEF1B alpha), guanine nucleotides, and aminoacyl-tRNA were studied kinetically by fluorescence stopped-flow....
- Activation of a C-terminal transcriptional activation domain of ERK5 by autophosphorylation
[作者:Morimoto, H; Kondoh, K; Nishimoto, S; Terasawa, K; Nishida, E,期刊:Journal of Biological Chemistry, 页码:35449-35456 , 文章类型: Article,,卷期:2007年282-49]
- ERK5 plays a crucial role in many biological processes by regulating transcription. ERK5 has a large C-terminal-half that contains a transcriptional activation domain. However, it has remained unclear how its transcripti...
- Histone deacetylase 3 down-regulates cholesterol synthesis through repression of lanosterol synthase gene expression
[作者:Villagra, A; Ulloa, N; Zhang, XH; Yuan, ZG; Sotomayor, E; Seto, E,期刊:Journal of Biological Chemistry, 页码:35457-35470 , 文章类型: Article,,卷期:2007年282-49]
- In vertebrates, a key step in the biosynthesis of cholesterol and steroid hormones is the conversion of (S)-2,3-oxidosqualene to lanosterol. The enzyme that catalyzes this complex cyclization/rearrangement step via the p...
- Pseudomonas fluorescens CHA0 produces enantio-pyochelin, the optical antipode of the pseudomonas aeruginosa siderophore pyochelin
[作者:Youard, ZA; Mislin, GLA; Majcherczyk, PA; Schalk, IJ; Reimmann, C,期刊:Journal of Biological Chemistry, 页码:35546-35553 , 文章类型: Article,,卷期:2007年282-49]
- The siderophore pyochelin is made by a thiotemplate mechanism from salicylate and two molecules of cysteine. In Pseudomonas aeruginosa, the first cysteine residue is converted to its D-isoform during thiazoline ring form...
- Methylation of bacterial release factors RF1 and RF2 is required for normal translation termination in vivo
[作者:Mora, L; Heurgue-Hamard, V; de Zamaroczy, M; Kervestin, S; Buckingham, RH,期刊:Journal of Biological Chemistry, 页码:35638-35645 , 文章类型: Article,,卷期:2007年282-49]
- Bacterial release factors RF1 and RF2 are methylated on the Gln residue of a universally conserved tripeptide motif GGQ, which interacts with the peptidyl transferase center of the large ribosomal subunit, triggering hyd...
- Evolution of differences in transport function in Slc11a family members
[作者:Techau, ME; Valdez-Taubas, J; Popoff, JF; Francis, R; Seaman, M; Blackwell, JM,期刊:Journal of Biological Chemistry, 页码:35646-35656 , 文章类型: Article,,卷期:2007年282-49]
- Slc11a1 ( formerly Nramp1) is a proton/divalent cation transporter that regulates cation homeostasis in macrophages. Slc11a2 mediates divalent cation uptake via the gut and delivery into cells. The mode of action of the ...
- Tandem phosphorylation of Ser-911 and Thr-912 at the C terminus of yeast plasma membrane H+-ATPase leads to glucose-dependent activation
[作者:Lecchi, S; Nelson, CJ; Allen, KE; Swaney, DL; Thompson, KL; Coon, JJ; Sussman, MR; Slayman, CW,期刊:Journal of Biological Chemistry, 页码:35471-35481 , 文章类型: Article,,卷期:2007年282-49]
- In recent years there has been growing interest in the post translational regulation of P-type ATPases by protein kinase mediated phosphorylation. Pma1 H+-ATPase, which is responsible for H+-dependent nutrient uptake in ...
- TNFR1 and TNFR2 signaling interplay in cardiac myocytes
[作者:Defer, N; Azroyan, A; Pecker, F; Pavoine, C,期刊:Journal of Biological Chemistry, 页码:35564-35573 , 文章类型: Article,,卷期:2007年282-49]
- Tumor necrosis factor alpha(TNF alpha) plays a major role in chronic heart failure, signaling through two different receptor subtypes, TNFR1 and TNFR2. Our aim was to further delineate the functional role and signaling p...
- Sts1 can overcome the loss of Rad23 and Rpn10 and represents a novel regulator of the ubiquitin/proteasome pathway
[作者:Romero-Perez, L; Chen, L; Lambertson, D; Madura, K,期刊:Journal of Biological Chemistry, 页码:35574-35582 , 文章类型: Article,,卷期:2007年282-49]
- A rad23 Delta rpn10 Delta double mutant accumulates multi-Ub proteins, is deficient in proteolysis, and displays sensitivity to drugs that generate damaged proteins. Overexpression of Sts1 restored normal growth in rad23...
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