- Detection of reactive oxygen species via endogenous oxidative pentose phosphate cycle activity in response to oxygen concentration - Implications for the mechanism of HIF-1 alpha stabilization under moderate hypoxia
[作者:Tuttle, SW; Maity, A; Oprysko, PR; Kachur, AV; Ayene, IS; Biaglow, JE; Koch, CJ,期刊:Journal of Biological Chemistry, 页码:36790-36796 , 文章类型: Article,,卷期:2007年282-51]
- The oxidative pentose phosphate cycle (OPPC) is necessary to maintain cellular reducing capacity during periods of increased oxidative stress. Metabolic flux through the OPPC increases stoichiometrically in response to a...
- DNA accelerates the inhibition of human cathepsin V by serpins
[作者:Ong, PC; McGowan, S; Pearce, MC; Irving, JA; Kan, WT; Grigoryev, SA; Turk, B; Silverman, GA; Brix, K; Bottomley, SP; Whisstock, JC; Pike, RN,期刊:Journal of Biological Chemistry, 页码:36980-36986 , 文章类型: Article,,卷期:2007年282-51]
- A balance between proteolytic activity and protease inhibition is crucial to the appropriate function of many biological processes. There is mounting evidence for the presence of both papain-like cysteine proteases and s...
- Site-specific effects of peptide lipidation on beta-Amyloid aggregation and cytotoxicity
[作者:Qahwash, IM; Boire, A; Lanning, J; Pytel, TKP; Meredith, SC,期刊:Journal of Biological Chemistry, 页码:36987-36997 , 文章类型: Article,,卷期:2007年282-51]
- beta-Amyloid (A beta) aggregates at low concentrations in vivo, and this may involve covalently modified forms of these peptides. Modification of A beta by 4-hydroxynonenal (4-HNE) initially increases the hydrophobicity ...
- Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis
[作者:Fuenzalida, K; Quintanilla, R; Ramos, P; Piderit, D; Fuentealba, RA; Martinez, G; Inestrosa, NC; Bronfman, M,期刊:Journal of Biological Chemistry, 页码:37006-37015 , 文章类型: Article,,卷期:2007年282-51]
- Peroxisome proliferator-activated receptor gamma(PPAR gamma) has been proposed as a therapeutic target for neurodegenerative diseases because of its anti-inflammatory action in glial cells. However, PPAR gamma agonists p...
- Identification of in Vivo phosphorylation sites and their functional significance in the sodium iodide symporter
[作者:Vadysirisack, DD; Chen, ESW; Zhang, Z; Tsai, MD; Chang, GD; Jhiang, SM,期刊:Journal of Biological Chemistry, 页码:36820-36828 , 文章类型: Article,,卷期:2007年282-51]
- The Na+/I- symporter (NIS)-mediated iodide uptake activity is the basis for targeted radioiodide ablation of thyroid cancers. Although it has been shown that NIS protein is phosphorylated, neither the in vivo phosphoryla...
- Signal peptide peptidase and gamma-secretase share equivalent inhibitor binding pharmacology
[作者:Iben, LG; Olson, RE; Balanda, LA; Jayachandra, S; Robertson, BJ; Hay, V; Corradi, J; Prasad, CVC; Zaczek, R; Albright, CF; Toyn, JH,期刊:Journal of Biological Chemistry, 页码:36829-36836 , 文章类型: Article,,卷期:2007年282-51]
- The enzyme gamma-secretase has long been considered a potential pharmaceutical target for Alzheimer disease. Presenilin ( the catalytic subunit of gamma-secretase) and signal peptide peptidase (SPP) are related transmemb...
- Negative regulation of inducible nitric-oxide synthase expression mediated through transforming growth factor-beta-dependent modulation of transcription factor TCF11
[作者:Berg, DT; Gupta, A; Richardson, MA; O'Brien, LA; Calnek, D; Grinnell, BW,期刊:Journal of Biological Chemistry, 页码:36837-36844 , 文章类型: Article,,卷期:2007年282-51]
- Inducible nitric-oxide synthase ( iNOS) plays a central role in the regulation of vascular function and response to injury. A central mediator controlling iNOS expression is transforming growth factor-beta (TGF-beta), wh...
- Mitochondrial ND5 gene variation associated with encephalomyopathy and mitochondrial ATP consumption
[作者:McKenzie, M; Liolitsa, D; Akinshina, N; Campanella, M; Sisodiya, S; Hargreaves, I; Nirmalananthan, N; Sweeney, MG; Abou-Sleiman, PM; Wood, NW; Hanna, MG; Duchen, MR,期刊:Journal of Biological Chemistry, 页码:36845-36852 , 文章类型: Article,,卷期:2007年282-51]
- Mitochondrial encephalomyopathy and lactic acidosis with strokelike episodes ( MELAS) is a severe young onset stroke disorder without effective treatment. We have identified a MELAS patient harboring a 13528A -> G mitoch...
- Lysophosphatidylcholine metabolism in Saccharomyces cerevisiae - The role of P-type ATPases in transport and a broad specificity acyltransferase in acylation
[作者:Riekhof, WR; Wu, J; Gijon, MA; Zarini, S; Murphy, RC; Voelker, DR,期刊:Journal of Biological Chemistry, 页码:36853-36861 , 文章类型: Article,,卷期:2007年282-51]
- We recently described a new route for the synthesis of phosphatidylethanolamine (PtdEtn) from exogenous lyso-PtdEtn, which we have termed the exogenous lysolipid metabolism ( ELM) pathway. The ELM pathway for lyso-PtdEtn...
- Interaction of the DYNLT (TCTEX1/RP3) light chains and the intermediate chains reveals novel intersubunit regulation during assembly of the dynein complex
[作者:Lo, KWH; Kogoy, JM; Rasoul, BA; King, SM; Pfister, KK,期刊:Journal of Biological Chemistry, 页码:36871-36878 , 文章类型: Article,,卷期:2007年282-51]
- The cytoplasmic dynein 1 cargo binding domain is formed by five subunits including the intermediate chain and the DYNLT, DYNLL, and DYNLRB light chain families. Six isoforms of the intermediate chain and two isoforms of ...
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