- Human Papillomavirus E7 requires the protease calpain to degrade the retinoblastoma protein
[作者:Darnell, GA; Schroder, WA; Antalis, TM; Lambley, E; Major, L; Gardner, J; Birrell, G; Cid-Arregui, A; Suhrbier, A,期刊:Journal of Biological Chemistry, 页码:37492-37500 , 文章类型: Article,,卷期:2007年282-52]
- Cervical cancers transformed by high risk human papilloma virus (HPV) express the E7 oncoprotein, which accelerates the degradation of the retinoblastoma protein (Rb). Here we show that the E7-mediated degradation of Rb ...
- Increased glucose disposal and AMP-dependent kinase signaling in a mouse model of hemochromatosis
[作者:Huang, JH; Gabrielsen, JS; Cooksey, RC; Luo, B; Boros, LG; Jones, DL; Jouihan, HA; Soesanto, Y; Knecht, L; Hazel, MW; Kushner, JP; McClain, DA,期刊:Journal of Biological Chemistry, 页码:37501-37507 , 文章类型: Article,,卷期:2007年282-52]
- Hereditary hemochromatosis is an inherited disorder of increased iron absorption that can result in cirrhosis, diabetes, and other morbidities. We have investigated the mechanisms underlying supranormal glucose tolerance...
- Cell wall-linked cryptococcal phospholipase B1 is a source of secreted enzyme and a determinant of cell wall integrity
[作者:Siafakas, AR; Sorrell, TC; Wright, LC; Wilson, C; Larsen, M; Boadle, R; Williamson, PR; Djordjevic, JT,期刊:Journal of Biological Chemistry, 页码:37508-37514 , 文章类型: Article,,卷期:2007年282-52]
- Phospholipase B (plb1) is secreted by pathogenic fungi and is a proven virulence determinant in Cryptococcus neoformans. Cell-associated plb1 is presumptively involved in fungal membrane biogenesis and remodelling. We ha...
- The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy
[作者:Hanada, T; Noda, NN; Satomi, Y; Ichimura, Y; Fujioka, Y; Takao, T; Inagaki, F; Ohsumi, Y,期刊:Journal of Biological Chemistry, 页码:37298-37302 , 文章类型: Article,,卷期:2007年282-52]
- Autophagy is a bulk degradation process in eukaryotic cells; autophagosomes enclose cytoplasmic components for degradation in the lysosome/vacuole. Autophagosome formation requires two ubiquitin-like conjugation systems,...
- A poised initiation complex is activated by SNF1
[作者:Tachibana, C; Biddick, R; Law, GL; Young, ET,期刊:Journal of Biological Chemistry, 页码:37308-37315 , 文章类型: Article,,卷期:2007年282-52]
- Snf1, the yeast AMP kinase homolog, is essential for derepression of glucose-repressed genes that are activated by Adr1. Although required for Adr1 DNA binding, the precise role of Snf1 is unknown. Deletion of histone de...
- An arthropod cuticular chitin-binding protein endows injured sites with transglutaminase-dependent mesh
[作者:Matsuda, Y; Koshiba, T; Osaki, T; Suyama, H; Arisaka, F; Toh, Y; Kawabata, SI,期刊:Journal of Biological Chemistry, 页码:37316-37324 , 文章类型: Article,,卷期:2007年282-52]
- In mammals, the cornified cell envelope forms beneath the plasma membrane in epithelia and provides a vital physical barrier consisting of insoluble proteins cross-linked by transglutaminase (TGase). In the horseshoe cra...
- Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells
[作者:Bawa-Khalfe, T; Cheng, JK; Wang, ZX; Yeh, ETH,期刊:Journal of Biological Chemistry, 页码:37341-37349 , 文章类型: Article,,卷期:2007年282-52]
- Prostate cancer, the most frequently diagnosed carcinoma in males, is readily modulated via the transcriptional activity of androgen receptors. Our recent publication reported that androgen receptor-dependent transcripti...
- Extracellular ATP mediates necrotic cell swelling in SN4741 dopaminergic neurons through P2X(7) receptors
[作者:Jun, DJ; Kim, J; Jung, SY; Song, R; Noh, JH; Park, YS; Ryu, SH; Kim, JH; Kong, YY; Chung, JM; Kim, KT,期刊:Journal of Biological Chemistry, 页码:37350-37358 , 文章类型: Article,,卷期:2007年282-52]
- Extracellular ATP has recently been identified as an important regulator of cell death in response to pathological insults. When SN4741 cells, which are dopaminergic neurons derived from the substantia nigra of transgeni...
- Mammalian gene PEG10 expresses two reading frames by high efficiency-1 frameshifting in embryonic-associated tissues
[作者:Clark, MB; Janicke, M; Gottesbuhren, U; Kleffmann, T; Legge, M; Poole, ES; Tate, WP,期刊:Journal of Biological Chemistry, 页码:37359-37369 , 文章类型: Article,,卷期:2007年282-52]
- Paternally expressed gene 10 ( PEG10) is a mammalian gene that is essential for embryonic development in mice. The gene contains two overlapping open reading frames ( ORF1 and ORF2) and is derived from a retroelement tha...
- Protein kinase a, not Epac, suppresses Hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells
[作者:Ji, ZY; Mei, FC; Johnson, BH; Thompson, EB; Cheng, XD,期刊:Journal of Biological Chemistry, 页码:37370-37377 , 文章类型: Article,,卷期:2007年282-52]
- Cyclic AMP synergizes strongly with glucocorticoids (GC) to induce apoptosis in normal or malignant lymphoid cells. We examined the individual roles that cAMP-dependent protein kinase (PKA) and Epac (exchange protein dir...
- The epithelial sodium channel (ENaC) traffics to apical membrane in lipid rafts in mouse cortical collecting duct cells
[作者:Hill, WG; Butterworth, MB; Wang, H; Edinger, RS; Lebowitz, J; Peters, KW; Frizzell, RA; Johnson, JP,期刊:Journal of Biological Chemistry, 页码:37402-37411 , 文章类型: Article,,卷期:2007年282-52]
- We previously showed that ENaC is present in lipid rafts in A6 cells, a Xenopus kidney cell line. We now demonstrate that ENaC can be detected in lipid rafts in mouse cortical collecting duct (MPKCCD14) cells by detergen...
- HIV-1 Tat activates dual Nox pathways leading to independent activation of ERK and JNK MAP kinases
[作者:Wu, RF; Ma, ZY; Myers, DP; Terada, LS,期刊:Journal of Biological Chemistry, 页码:37412-37419 , 文章类型: Article,,卷期:2007年282-52]
- Human immunodeficiency virus, type 1 Tat is known to exert pleiotropic effects on the vascular endothelium through mitogen-activated protein (MAP) kinases, although the signaling pathways leading to MAP kinase activation...
- Distinguishing aggrecan loss from aggrecan proteolysis in ADAMTS-4 and ADAMTS-5 single and double deficient mice
[作者:Ilic, MZ; East, CJ; Rogerson, FM; Fosang, AJ; Handley, CJ,期刊:Journal of Biological Chemistry, 页码:37420-37428 , 文章类型: Article,,卷期:2007年282-52]
- Aggrecan loss from mouse cartilage is predominantly because of ADAMTS-5 activity; however, the relative contribution of other proteolytic and nonproteolytic processes to this loss is not clear. This is the first study to...
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