- Targeted 2 '-O Methylation at a Nucleotide within the Pseudoknot of Telomerase RNA Reduces Telomerase Activity In Vivo
[作者:Huang, C; Yu, YT,期刊:Molecular and Cellular Biology, 页码:4368-4378 , 文章类型: Article,,卷期:2010年30-18]
- Telomerase RNA is an essential component of telomerase, a ribonucleoprotein enzyme that maintains chromosome ends in most eukaryotes. Here we employ a novel approach, namely, RNA-guided RNA modification, to assess whethe...
- Evolutionarily Conserved Role of Calcineurin in Phosphodegron-Dependent Degradation of Phosphodiesterase 4D
[作者:Zhu, H; Suk, HY; Yu, RYL; Brancho, D; Olabisi, O; Yang, TTC; Yang, XY; Zhang, JL; Moussaif, M; Durand, JL; Jelicks, LA; Kim, JY; Scherer, PE; Frank, PG; Lisanti, MP; Calvert, JW; Duranski, MR; Lefer, DJ; Huston, E; Baillie, GS; Houslay, MD; Molkentin, JD; Jin, JP; Chow, CW,期刊:Molecular and Cellular Biology, 页码:4379-4390 , 文章类型: Article,,卷期:2010年30-18]
- Calcineurin is a widely expressed and highly conserved Ser/Thr phosphatase. Calcineurin is inhibited by the immunosuppressant drug cyclosporine A (CsA) or tacrolimus (FK506). The critical role of CsA/FK506 as an immunosu...
- The Expression Profile of the Major Mouse SPO11 Isoforms Indicates that SPO11 beta Introduces Double Strand Breaks and Suggests that SPO11 alpha Has an Additional Role in Prophase in both Spermatocytes and Oocytes
[作者:Bellani, MA; Boateng, KA; McLeod, D; Camerini-Otero, RD,期刊:Molecular and Cellular Biology, 页码:4391-4403 , 文章类型: Article,,卷期:2010年30-18]
- Both in mice and humans, two major SPO11 isoforms are generated by alternative splicing: SPO11 alpha (exon 2 skipped) and SPO11 beta. Thus, the alternative splicing event must have emerged before the mouse and human line...
- The C-Terminal Region of Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes mRNA Recruitment, Scanning, and, Together with eIF3j and the eIF3b RNA Recognition Motif, Selection of AUG Start Codons
[作者:Chiu, WL; Wagner, S; Herrmannova, A; Burela, L; Zhang, F; Saini, AK; Valasek, L; Hinnebusch, AG,期刊:Molecular and Cellular Biology, 页码:4415-4434 , 文章类型: Article,,卷期:2010年30-18]
- The C-terminal domain (CTD) of the a/Tif32 subunit of budding yeast eukaryotic translation initiation factor 3 (eIF3) interacts with eIF3 subunits j/Hcr1 and b/Prt1 and can bind helices 16 to 18 of 18S rRNA, suggesting p...
- A Novel Mechanism for SUMO System Control: Regulated Ulp1 Nucleolar Sequestration
[作者:Sydorskyy, Y; Srikumar, T; Jeram, SM; Wheaton, S; Vizeacoumar, FJ; Makhnevych, T; Chong, YT; Gingras, AC; Raught, B,期刊:Molecular and Cellular Biology, 页码:4452-4462 , 文章类型: Article,,卷期:2010年30-18]
- The small ubiquitin-related modifiers (SUMOs) are evolutionarily conserved polypeptides that are co-valently conjugated to protein targets to modulate their subcellular localization, half-life, or activity. Steady-state ...
- Type I Phosphatidylinositol Phosphate Kinase Beta Regulates Focal Adhesion Disassembly by Promoting beta 1 Integrin Endocytosis
[作者:Chao, WT; Ashcroft, F; Daquinag, AC; Vadakkan, T; Wei, ZB; Zhang, PM; Dickinson, ME; Kunz, J,期刊:Molecular and Cellular Biology, 页码:4463-4479 , 文章类型: Article,,卷期:2010年30-18]
- Cell migration requires the regulated disassembly of focal adhesions, but the underlying mechanisms remain poorly defined. We have previously shown that focal adhesion disassembly requires the dynamin 2- and clathrin-dep...
- Analysis of Leigh Syndrome Mutations in the Yeast SURF1 Homolog Reveals a New Member of the Cytochrome Oxidase Assembly Factor Family
[作者:Bestwick, M; Jeong, MY; Khalimonchuk, O; Kim, H; Winge, DR,期刊:Molecular and Cellular Biology, 页码:4480-4491 , 文章类型: Article,,卷期:2010年30-18]
- Three missense SURF1 mutations identified in patients with Leigh syndrome (LS) were evaluated in the yeast homolog Shy1 protein. Introduction of two of the Leigh mutations, (FT)-T-249 and (YD)-D-344, in Shy1 failed to si...
- The Molecular Basis of Phospholipase D2-Induced Chemotaxis: Elucidation of Differential Pathways in Macrophages and Fibroblasts
[作者:Knapek, K; Frondorf, K; Post, J; Short, S; Cox, D; Gomez-Cambronero, J,期刊:Molecular and Cellular Biology, 页码:4492-4506 , 文章类型: Article,,卷期:2010年30-18]
- We report the molecular mechanisms that underlie chemotaxis of macrophages and cell migration of fibroblasts, cells that are essential during the body's innate immune response and during wound repair, respectively. Silen...
- Differential NDR/LATS Interactions with the Human MOB Family Reveal a Negative Role for Human MOB2 in the Regulation of Human NDR Kinases
[作者:Kohler, RS; Schmitz, D; Cornils, H; Hemmings, BA; Hergovich, A,期刊:Molecular and Cellular Biology, 页码:4507-4520 , 文章类型: Article,,卷期:2010年30-18]
- MOB proteins are integral components of signaling pathways controlling important cellular processes, such as mitotic exit, centrosome duplication, apoptosis, and cell proliferation in eukaryotes. The human MOB protein fa...
- Single-Molecule Analysis Reveals Changes in the DNA Replication Program for the POU5F1 Locus upon Human Embryonic Stem Cell Differentiation
[作者:Schultz, SS; Desbordes, SC; Du, Z; Kosiyatrakul, S; Lipchina, I; Studer, L; Schildkraut, CL,期刊:Molecular and Cellular Biology, 页码:4521-4534 , 文章类型: Article,,卷期:2010年30-18]
Human embryonic stem cells (hESCs), due to their pluripotent nature, represent a particularly relevant model system to study the relationship between the replication program and differentiation state. Here, we define ...
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