- Unbiased, Genome-Wide In Vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-Specific Liver Gene Expression
[作者:Ling, GY; Sugathan, A; Mazor, T; Fraenkel, E; Waxman, DJ,期刊:Molecular and Cellular Biology, 页码:5531-5544 , 文章类型: Article,,卷期:2010年30-23]
- We have used a simple and efficient method to identify condition-specific transcriptional regulatory sites in vivo to help elucidate the molecular basis of sex-related differences in transcription, which are widespread i...
- The Protein Kinase C Cascade Regulates Recruitment of Matrix Metalloprotease 9 to Podosomes and Its Release and Activation
[作者:Xiao, HL; Bai, XH; Kapus, A; Lu, WY; Mak, AS; Liu, MY,期刊:Molecular and Cellular Biology, 页码:5545-5561 , 文章类型: Article,,卷期:2010年30-23]
- Podosomes are transient cell surface structures essential for degradation of extracellular matrix during cell invasion. Protein kinase C (PKC) is involved in the regulation of podosome formation; however, the roles of in...
- Dual Functions of Nbs1 in the Repair of DNA Breaks and Proliferation Ensure Proper V(D)J Recombination and T-Cell Development
[作者:Saidi, A; Li, TL; Weih, F; Concannon, P; Wang, ZQ,期刊:Molecular and Cellular Biology, 页码:5572-5581 , 文章类型: Article,,卷期:2010年30-23]
- Immunodeficiency and lymphoid malignancy are hallmarks of the human disease Nijmegen breakage syndrome (NBS; OMIM 251260), which is caused by NBS1 mutations. Although NBS1 has been shown to bind to the T-cell receptor al...
- The Adaptor Protein TRIP6 Antagonizes Fas-Induced Apoptosis but Promotes Its Effect on Cell Migration
[作者:Lai, YJ; Lin, VTG; Zheng, Y; Benveniste, EN; Lin, FT,期刊:Molecular and Cellular Biology, 页码:5582-5596 , 文章类型: Article,,卷期:2010年30-23]
- The Fas/CD95 receptor mediates apoptosis but is also capable of triggering nonapoptotic signals. However, the mechanisms that selectively regulate these opposing effects are not yet fully understood. Here we demonstrate ...
- Progesterone Receptor Induces ErbB-2 Nuclear Translocation To Promote Breast Cancer Growth via a Novel Transcriptional Effect: ErbB-2 Function as a Coactivator of Stat3
[作者:Beguelin, W; Flaque, MCD; Proietti, CJ; Cayrol, F; Rivas, MA; Tkach, M; Rosemblit, C; Tocci, JM; Charreau, EH; Schillaci, R; Elizalde, PV,期刊:Molecular and Cellular Biology, 页码:5456-5472 , 文章类型: Article,,卷期:2010年30-23]
- Progesterone receptor (PR) and ErbB-2 bidirectional cross talk participates in breast cancer development. Here, we identified a new mechanism of the PR and ErbB-2 interaction involving the PR induction of ErbB-2 nuclear ...
- Genome-Wide Distribution of MacroH2A1 Histone Variants in Mouse Liver Chromatin
[作者:Changolkar, LN; Singh, G; Cui, KR; Berletch, JB; Zhao, KJ; Disteche, CM; Pehrson, JR,期刊:Molecular and Cellular Biology, 页码:5473-5483 , 文章类型: Article,,卷期:2010年30-23]
- Studies of macroH2A histone variants indicate that they have a role in regulating gene expression. To identify direct targets of the macroH2A1 variants, we produced a genome-wide map of the distribution of macroH2A1 nucl...
- Characterization of Puma-Dependent and Puma-Independent Neuronal Cell Death Pathways following Prolonged Proteasomal Inhibition
[作者:Tuffy, LP; Concannon, CG; D'Orsi, B; King, MA; Woods, I; Huber, HJ; Ward, MW; Prehn, JHM,期刊:Molecular and Cellular Biology, 页码:5484-5501 , 文章类型: Article,,卷期:2010年30-23]
- Proteasomal stress and the accumulation of polyubiquitinated proteins are key features of numerous neurodegenerative disorders. Previously we demonstrated that stabilization of p53 and activation of its target gene, puma...
- A TFIIH-Associated Mediator Head Is a Basal Factor of Small Nuclear Spliced Leader RNA Gene Transcription in Early-Diverged Trypanosomes
[作者:Lee, JH; Cai, G; Panigrahi, AK; Dunham-Ems, S; Nguyen, TN; Radolf, JD; Asturias, FJ; Gunzl, A,期刊:Molecular and Cellular Biology, 页码:5502-5513 , 文章类型: Article,,卷期:2010年30-23]
- Genome annotation suggested that early-diverged kinetoplastids possess a reduced set of basal transcription factors. More recent work, however, on the lethal parasite Trypanosoma brucei identified extremely divergent ort...
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