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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共18条记录   Molecular Architecture of the Human Prp19/CDC5L Complex [作者：Grote, M; Wolf, E; Will, CL; Lemm, I; Agafonov, DE; Schomburg, A; Fischle, W; Urlaub, H; Luhrmann, R,期刊：Molecular and Cellular Biology, 页码：2105-2119 , 文章类型： Article，,卷期：2010年30-9] Protein complexes containing Prp19 play a central role during catalytic activation of the spliceosome, and Prp19 and its related proteins are major components of the spliceosome's catalytic core RNP. To learn more about ... PRH/Hhex Controls Cell Survival through Coordinate Transcriptional Regulation of Vascular Endothelial Growth Factor Signaling [作者：Noy, P; Williams, H; Sawasdichai, A; Gaston, K; Jayaraman, PS,期刊：Molecular and Cellular Biology, 页码：2120-2134 , 文章类型： Article，,卷期：2010年30-9] The proline-rich homeodomain protein (PRH) plays multiple roles in the control of gene expression during embryonic development and in the adult. Vascular endothelial growth factor (VEGF) is a mitogen that stimulates cell... CENP-A Reduction Induces a p53-Dependent Cellular Senescence Response To Protect Cells from Executing Defective Mitoses [作者：Maehara, K; Takahashi, K; Saitoh, S,期刊：Molecular and Cellular Biology, 页码：2090-2104 , 文章类型： Article，,卷期：2010年30-9] Cellular senescence is an irreversible growth arrest and is presumed to be a natural barrier to tumor development. Like telomere shortening, certain defects in chromosome integrity can trigger senescence; however, the ro... Control of Adipogenesis by the SUMO-Specific Protease SENP2 [作者：Chung, SS; Ahn, BY; Kim, M; Choi, HH; Park, HS; Kang, S; Park, SG; Kim, YB; Cho, YM; Lee, HK; Chung, CH; Park, KS,期刊：Molecular and Cellular Biology, 页码：2135-2146 , 文章类型： Article，,卷期：2010年30-9] Here, we demonstrate that SENP2, a desumoylating enzyme, plays a critical role in the control of adipogenesis. SENP2 expression was markedly increased upon the induction of adipocyte differentiation, and this increase wa... Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNA(Leu(UUR)) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes [作者：Li, RH; Guan, MX,期刊：Molecular and Cellular Biology, 页码：2147-2154 , 文章类型： Article，,卷期：2010年30-9] Mutations in mitochondrial tRNA genes are associated with a wide spectrum of human diseases. In particular, the tRNA(Leu(UUR)) A3243G mutation causes mitochondrial encephalomyopathy, lactic acidosis, and stroke-like symp... Functional Interplay between Acetylation and Methylation of the RelA Subunit of NF-kappa B [作者：Yang, XD; Tajkhorshid, E; Chen, LF,期刊：Molecular and Cellular Biology, 页码：2170-2180 , 文章类型： Article，,卷期：2010年30-9] Posttranslational modifications of the RelA subunit of NF-kappa B, including acetylation and methylation, play a key role in controlling the strength and duration of its nuclear activity. Whether these modifications are ... The TAL1/SCL Transcription Factor Regulates Cell Cycle Progression and Proliferation in Differentiating Murine Bone Marrow Monocyte Precursors [作者：Dey, S; Curtis, DJ; Jane, SM; Brandt, SJ,期刊：Molecular and Cellular Biology, 页码：2181-2192 , 文章类型： Article，,卷期：2010年30-9] Monocytopoiesis involves the stepwise differentiation in the bone marrow (BM) of common myeloid precursors (CMPs) to monocytes. The basic helix-loop-helix transcription factor TAL1/SCL plays a critical role in other hema... MED14 Tethers Mediator to the N-Terminal Domain of Peroxisome Proliferator-Activated Receptor gamma and Is Required for Full Transcriptional Activity and Adipogenesis [作者：Grontved, L; Madsen, MS; Boergesen, M; Roeder, RG; Mandrup, S,期刊：Molecular and Cellular Biology, 页码：2155-2169 , 文章类型： Article，,卷期：2010年30-9] The Mediator subunit MED1/TRAP220/DRIP205/PBP interacts directly with many nuclear receptors and was long thought to be responsible for tethering Mediator to peroxisome proliferator-activated receptor (PPAR)-responsive p... Par1b/MARK2 Phosphorylates Kinesin-Like Motor Protein GAKIN/KIF13B To Regulate Axon Formation [作者：Yoshimura, Y; Terabayashi, T; Miki, H,期刊：Molecular and Cellular Biology, 页码：2206-2219 , 文章类型： Article，,卷期：2010年30-9] Here we report that Par1b/MARK2 regulates axon formation via phosphorylation of a kinesin superfamily protein GAKIN/KIF13B. Accumulating evidence indicated the importance of the evolutionarily conserved kinase Par1b in t... HMGA1a Trapping of U1 snRNP at an Authentic 5 ' Splice Site Induces Aberrant Exon Skipping in Sporadic Alzheimer's Disease [作者：Ohe, K; Mayeda, A,期刊：Molecular and Cellular Biology, 页码：2220-2228 , 文章类型： Article，,卷期：2010年30-9] Overexpression of high-mobility group A protein 1a (HMGA1a) causes aberrant exon 5 skipping of the Presenilin-2 (PS2) pre-mRNA, which is almost exclusively detected in patients with sporadic Alzheimer's disease. An elect... The SUMO E3 Ligase Activity of Pc2 Is Coordinated through a SUMO Interaction Motif [作者：Yang, SH; Sharrocks, AD,期刊：Molecular and Cellular Biology, 页码：2193-2205 , 文章类型： Article，,卷期：2010年30-9] Protein modification by SUMO conjugation has emerged to be an important regulatory event. Recently, the mechanisms through which SUMO elicits its effects on target proteins have been elucidated. One of these is the nonco... p27(kip1) Controls Cell Morphology and Motility by Regulating Microtubule-Dependent Lipid Raft Recycling [作者：Belletti, B; Pellizzari, I; Berton, S; Fabris, L; Wolf, K; Lovat, F; Schiappacassi, M; D'Andrea, S; Nicoloso, MS; Lovisa, S; Sonego, M; Defilippi, P; Vecchione, A; Colombatti, A; Friedl, P; Baldassarre, G,期刊：Molecular and Cellular Biology, 页码：2229-2240 , 文章类型： Article，,卷期：2010年30-9] p27(kip1) (p27) is an inhibitor of cyclin/cyclin-dependent kinase complexes, whose nuclear loss indicates a poor prognosis in various solid tumors. When located in the cytoplasm, p27 binds Op18/stathmin (stathmin), a mic... Microtubule Stabilization by Bone Morphogenetic Protein Receptor-Mediated Scaffolding of c-Jun N-Terminal Kinase Promotes Dendrite Formation [作者：Podkowa, M; Zhao, X; Chow, CW; Coffey, ET; Davis, RJ; Attisano, L,期刊：Molecular and Cellular Biology, 页码：2241-2250 , 文章类型： Article，,卷期：2010年30-9] Neuronal outgrowth occurs via coordinated remodeling of the cytoskeleton involving both actin and microtubules. Microtubule stabilization drives the extending neurite, yet little is known of the molecular mechanisms wher... Repression of Transcriptional Activity of C/EBP alpha by E2F-Dimerization Partner Complexes [作者：Zaragoza, K; Begay, V; Schuetz, A; Heinemann, U; Leutz, A,期刊：Molecular and Cellular Biology, 页码：2293-2304 , 文章类型： Article，,卷期：2010年30-9] The transcription factor CCAAT/enhancer-binding protein alpha (C/EBP alpha) coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, keratinocytes, and cells of the lung a... The RasGAP Proteins Ira2 and Neurofibromin Are Negatively Regulated by Gpb1 in Yeast and ETEA in Humans [作者：Phan, VT; Ding, VW; Li, FL; Chalkley, RJ; Burlingame, A; McCormick, F,期刊：Molecular and Cellular Biology, 页码：2264-2279 , 文章类型： Article，,卷期：2010年30-9] The neurofibromatosis type 1 (NF1) gene encodes the GTPase-activating protein (GAP) neurofibromin, which negatively regulates Ras activity. The yeast Saccharomyces cerevisiae has two neurofibromin homologs, Ira1 and Ira2... TEX14 Interacts with CEP55 To Block Cell Abscission [作者：Iwamori, T; Iwamori, N; Ma, L; Edson, MA; Greenbaum, MP; Matzuk, MM,期刊：Molecular and Cellular Biology, 页码：2280-2292 , 文章类型： Article，,卷期：2010年30-9] In somatic cells, abscission, the physical separation of daughter cells at the completion of cytokinesis, requires CEP55, ALIX, and TSG101. In contrast, cytokinesis is arrested prior to abscission in differentiating male...