- The H3K27me3 Demethylase dUTX Is a Suppressor of Notch- and Rb-Dependent Tumors in Drosophila
[作者:Herz, HM; Madden, LD; Chen, ZH; Bolduc, C; Buff, E; Gupta, R; Davuluri, R; Shilatifard, A; Hariharan, IK; Bergmann, A,期刊:Molecular and Cellular Biology, 页码:2485-2497 , 文章类型: Article,,卷期:2010年30-10]
- Trimethylated lysine 27 of histone H3 (H3K27me3) is an epigenetic mark for gene silencing and can be demethylated by the JmjC domain of UTX. Excessive H3K27me3 levels can cause tumorigenesis, but little is known about th...
- Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3 beta Signaling
[作者:Edouard, T; Combier, JP; Nedelec, A; Bel-Vialar, S; Metrich, M; Conte-Auriol, F; Lyonnet, S; Parfait, B; Tauber, M; Salles, JP; Lezoualc'h, F; Yart, A; Raynal, P,期刊:Molecular and Cellular Biology, 页码:2498-2507 , 文章类型: Article,,卷期:2010年30-10]
- LEOPARD syndrome (LS), a disorder with multiple developmental abnormalities, is mainly due to mutations that impair the activity of the tyrosine phosphatase SHP2 (PTPN11). How these alterations cause the disease remains ...
- Runx1 Directly Promotes Proliferation of Hair Follicle Stem Cells and Epithelial Tumor Formation in Mouse Skin
[作者:Hoi, CSL; Lee, SE; Lu, SY; McDermitt, DJ; Osorio, KM; Piskun, CM; Peters, RM; Paus, R; Tumbar, T,期刊:Molecular and Cellular Biology, 页码:2518-2536 , 文章类型: Article,,卷期:2010年30-10]
- Runx1/AML1 is a transcription factor implicated in tissue stem cell regulation and belongs to the small Runx family of cancer genes. In the hair follicle (HF), Runx1 epithelial deletion in morphogenesis impairs normal ad...
- Drosophila RB Proteins Repress Differentiation-Specific Genes via Two Different Mechanisms
[作者:Lee, H; Ohno, K; Voskoboynik, Y; Ragusano, L; Martinez, A; Dimova, DK,期刊:Molecular and Cellular Biology, 页码:2563-2577 , 文章类型: Article,,卷期:2010年30-10]
- The RB and E2F proteins play important roles in the regulation of cell division, cell death, and development by controlling the expression of genes involved in these processes. The mechanisms of repression by the retinob...
- A Novel Transcriptional Repressor, Rhit, Is Involved in Heat-Inducible and Age-Dependent Expression of Mpv17-Like Protein, a Participant in Reactive Oxygen Species Metabolism
[作者:Iida, R; Ueki, M; Yasuda, T,期刊:Molecular and Cellular Biology, 页码:2306-2315 , 文章类型: Article,,卷期:2010年30-10]
- Mpv17-like protein (M-LP) is a protein that has been suggested to be involved in the metabolism of reactive oxygen species. The two M-LP isoforms in mouse, M-LPS and M-LPL, are generated by the alternative usage of promo...
- Differential Requirement for H2AX and 53BP1 in Organismal Development and Genome Maintenance in the Absence of Poly(ADP)ribosyl Polymerase 1
[作者:Orsburn, B; Escudero, B; Prakash, M; Gesheva, S; Liu, GS; Huso, DL; Franco, S,期刊:Molecular and Cellular Biology, 页码:2341-2352 , 文章类型: Article,,卷期:2010年30-10]
- Combined deficiencies of poly(ADP)ribosyl polymerase 1 (PARP1) and ataxia telangiectasia mutated (ATM) result in synthetic lethality and, in the mouse, early embryonic death. Here, we investigated the genetic requirement...
- SWR1 Complex Poises Heterochromatin Boundaries for Antisilencing Activity Propagation
[作者:Zhou, BO; Wang, SS; Xu, LX; Meng, FL; Xuan, YJ; Duan, YM; Wang, JY; Hu, H; Dong, XC; Ding, JP; Zhou, JQ,期刊:Molecular and Cellular Biology, 页码:2391-2400 , 文章类型: Article,,卷期:2010年30-10]
- In eukaryotes, chromosomal processes are usually modulated through chromatin-modifying complexes that are dynamically targeted to specific regions of chromatin. In this study, we show that the chromatin-remodeling comple...
- Mechanism of Mediator Recruitment by Tandem Gcn4 Activation Domains and Three Gal11 Activator-Binding Domains
[作者:Herbig, E; Warfield, L; Fish, L; Fishburn, J; Knutson, BA; Moorefield, B; Pacheco, D; Hahn, S,期刊:Molecular and Cellular Biology, 页码:2376-2390 , 文章类型: Article,,卷期:2010年30-10]
- Targets of the tandem Gcn4 acidic activation domains in transcription preinitiation complexes were identified by site-specific cross-linking. The individual Gcn4 activation domains cross-link to three common targets, Gal...
- Identification of SNAPc Subunit Domains That Interact with Specific Nucleotide Positions in the U1 and U6 Gene Promoters
[作者:Kim, MK; Kang, YS; Lai, HT; Barakat, NH; Magante, D; Stumph, WE,期刊:Molecular and Cellular Biology, 页码:2411-2423 , 文章类型: Article,,卷期:2010年30-10]
- The small nuclear RNA (snRNA)-activating protein complex (SNAPc) is essential for transcription of genes coding for the snRNAs (U1, U2, etc.). In Drosophila melanogaster, the heterotrimeric DmSNAPc recognizes a 21-bp DNA...
- Phospholipase C gamma Activation Drives Increased Production of Autotaxin in Endothelial Cells and Lysophosphatidic Acid-Dependent Regression
[作者:Im, E; Motiejunaite, R; Aranda, J; Park, EY; Federico, L; Kim, TI; Clair, T; Stracke, ML; Smyth, S; Kazlauskas, A,期刊:Molecular and Cellular Biology, 页码:2401-2410 , 文章类型: Article,,卷期:2010年30-10]
- We previously reported that vascular endothelial growth factor (VEGF)-dependent activation of phospholipase C gamma 1 (PLC gamma) regulated tube stability by competing with phosphoinositide 3-kinase (PI3K) for their comm...
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