- Glucose Controls Nuclear Accumulation, Promoter Binding, and Transcriptional Activity of the MondoA-Mlx Heterodimer
[作者:Peterson, CW; Stoltzman, CA; Sighinolfi, MP; Han, KS; Ayer, DE,期刊:Molecular and Cellular Biology, 页码:2887-2895 , 文章类型: Article,,卷期:2010年30-12]
- Maintenance of energy homeostasis is a fundamental requirement for organismal fitness: defective glucose homeostasis underlies numerous metabolic diseases and cancer. At the cellular level, the ability to sense and adapt...
- Lin9, a Subunit of the Mammalian DREAM Complex, Is Essential for Embryonic Development, for Survival of Adult Mice, and for Tumor Suppression
[作者:Reichert, N; Wurster, S; Ulrich, T; Schmitt, K; Hauser, S; Probst, L; Gotz, R; Ceteci, F; Moll, R; Rapp, U; Gaubatz, S,期刊:Molecular and Cellular Biology, 页码:2896-2908 , 文章类型: Article,,卷期:2010年30-12]
- The retinoblastoma tumor suppressor protein (pRB) and related p107 and p130 "pocket proteins" function together with the E2F transcription factors to repress gene expression during the cell cycle and development. Recent ...
- Genetic Demonstration of a Redundant Role of Extracellular Signal-Regulated Kinase 1 (ERK1) and ERK2 Mitogen-Activated Protein Kinases in Promoting Fibroblast Proliferation
[作者:Voisin, L; Saba-El-Leil, MK; Julien, C; Fremin, C; Meloche, S,期刊:Molecular and Cellular Biology, 页码:2918-2932 , 文章类型: Article,,卷期:2010年30-12]
- The extracellular signal-regulated kinase 1 and 2 (ERK1/2) mitogen-activated protein (MAP) kinase signaling pathway plays an important role in the proliferative response of mammalian cells to mitogens. However, the indiv...
- Stat5 Promotes Survival of Mammary Epithelial Cells through Transcriptional Activation of a Distinct Promoter in Akt1
[作者:Creamer, BA; Sakamoto, K; Schmidt, JW; Triplett, AA; Moriggl, R; Wagner, KU,期刊:Molecular and Cellular Biology, 页码:2957-2970 , 文章类型: Article,,卷期:2010年30-12]
- The signal transducer and activator of transcription 5 (Stat5) plays a pivotal role in the proliferation, secretory differentiation, and survival of mammary epithelial cells. However, there is little information about St...
- Multiple E2F-Induced MicroRNAs Prevent Replicative Stress in Response to Mitogenic Signaling
[作者:Bueno, MJ; de Cedron, MG; Laresgoiti, U; Fernandez-Piqueras, J; Zubiaga, AM; Malumbres, M,期刊:Molecular and Cellular Biology, 页码:2983-2995 , 文章类型: Article,,卷期:2010年30-12]
- Transcription of microRNAs (miRNAs) is thought to be regulated similarly to that of protein-coding genes. However, how miRNAs are regulated during the cell division cycle is not well understood. We have analyzed the tran...
- TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo
[作者:Abreu, E; Aritonovska, E; Reichenbach, P; Cristofari, G; Culp, B; Terns, RM; Lingner, J; Terns, MP,期刊:Molecular and Cellular Biology, 页码:2971-2982 , 文章类型: Article,,卷期:2010年30-12]
- Recruitment to telomeres is a pivotal step in the function and regulation of human telomerase; however, the molecular basis for recruitment is not known. Here, we have directly investigated the process of telomerase recr...
- The ATDC (TRIM29) Protein Binds p53 and Antagonizes p53-Mediated Functions
[作者:Yuan, ZG; Villagra, A; Peng, LR; Coppola, D; Glozak, M; Sotomayor, EM; Chen, JD; Lane, WS; Seto, E,期刊:Molecular and Cellular Biology, 页码:3004-3015 , 文章类型: Article,,卷期:2010年30-12]
- The ataxia telangiectasia group D-complementing (ATDC) gene product, also known as TRIM29, is a member of the tripartite motif (TRIM) protein family. ATDC has been proposed to form homo-or heterodimers and to bind nuclei...
- Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1
[作者:Taguchi, K; Maher, JM; Suzuki, T; Kawatani, Y; Motohashi, H; Yamamoto, M,期刊:Molecular and Cellular Biology, 页码:3016-3026 , 文章类型: Article,,卷期:2010年30-12]
- Keap1 regulates Nrf2 activity in response to xenobiotic and oxidative stresses. Nrf2 is an essential regulator of cytoprotective genes. Keap1-null mice are lethal by weaning age due to malnutrition caused by severe hyper...
- SORLA/SORL1 Functionally Interacts with SPAK To Control Renal Activation of Na+-K+-Cl- Cotransporter 2
[作者:Reiche, J; Theilig, F; Rafiqi, FH; Carlo, AS; Militz, D; Mutig, K; Todiras, M; Christensen, EI; Ellison, DH; Bader, M; Nykjaer, A; Bachmann, S; Alessi, D; Willnow, TE,期刊:Molecular and Cellular Biology, 页码:3027-3037 , 文章类型: Article,,卷期:2010年30-12]
- Proper control of NaCl excretion in the kidney is central to bodily functions, yet many mechanisms that regulate reabsorption of sodium and chloride in the kidney remain incompletely understood. Here, we identify an impo...
- Ubiquitin-Independent Degradation of Antiapoptotic MCL-1
[作者:Stewart, DP; Koss, B; Bathina, M; Perciavalle, RM; Bisanz, K; Opferman, JT,期刊:Molecular and Cellular Biology, 页码:3099-3110 , 文章类型: Article,,卷期:2010年30-12]
- Antiapoptotic myeloid cell leukemia 1 (MCL-1) is an essential modulator of survival during the development and maintenance of a variety of cell lineages. Its turnover, believed to be mediated by the ubiquitin-proteasome ...
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