- mTORC1 Directly Phosphorylates and Regulates Human MAF1
[作者：Michels, AA; Robitaille, AM; Buczynski-Ruchonnet, D; Hodroj, W; Reina, JH; Hall, MN; Hernandez, N,期刊：Molecular and Cellular Biology, 页码：3749-3757 , 文章类型： Article，,卷期：2010年30-15]
- mTORC1 is a central regulator of growth in response to nutrient availability, but few direct targets have been identified. RNA polymerase (pol) III produces a number of essential RNA molecules involved in protein synthes...
- A Novel Fluorescent Sensor Protein for Visualization of Redox States in the Cytoplasm and in Peroxisomes
[作者：Yano, T; Oku, M; Akeyama, N; Itoyama, A; Yurimoto, H; Kuge, S; Fujiki, Y; Sakai, Y,期刊：Molecular and Cellular Biology, 页码：3758-3766 , 文章类型： Article，,卷期：2010年30-15]
- Reactive oxygen species are generated within peroxisomes during peroxisomal metabolism. However, due to technological difficulties, the intraperoxisomal redox state remain elusive, and the effect of peroxisome deficiency...
- Drosophila von Hippel-Lindau Tumor Suppressor Gene Function in Epithelial Tubule Morphogenesis
[作者：Hsouna, A; Nallamothu, G; Kose, N; Guinea, M; Dammai, V; Hsu, T,期刊：Molecular and Cellular Biology, 页码：3779-3794 , 文章类型： Article，,卷期：2010年30-15]
- Mutations in the human von Hippel-Lindau (VHL) gene are the cause of VHL disease that displays multiple benign and malignant tumors. The VHL gene has been shown to regulate angiogenic potential and glycolic metabolism vi...
- Interplay between DNA Methylation and Transcription Factor Availability: Implications for Developmental Activation of the Mouse Myogenin Gene
[作者：Palacios, D; Summerbell, D; Rigby, PWJ; Boyes, J,期刊：Molecular and Cellular Biology, 页码：3805-3815 , 文章类型： Article，,卷期：2010年30-15]
- During development, gene activation is stringently regulated to restrict expression only to the correct cell type and correct developmental stage. Here, we present mechanistic evidence that suggests DNA methylation contr...
- Epidermal Growth Factor Receptor Activation Remodels the Plasma Membrane Lipid Environment To Induce Nanocluster Formation
[作者：Ariotti, N; Liang, H; Xu, YF; Zhang, YQ; Yonekubo, Y; Inder, K; Du, GW; Parton, RG; Hancock, JF; Plowman, SJ,期刊：Molecular and Cellular Biology, 页码：3795-3804 , 文章类型： Article，,卷期：2010年30-15]
- Signal transduction is regulated by the lateral segregation of proteins into nanodomains on the plasma membrane. However, the molecular mechanisms that regulate the lateral segregation of cell surface receptors, such as ...
- Sphingosine Kinase 1 Induces Tolerance to Human Epidermal Growth Factor Receptor 2 and Prevents Formation of a Migratory Phenotype in Response to Sphingosine 1-Phosphate in Estrogen Receptor-Positive Breast Cancer Cells
[作者：Long, JS; Edwards, J; Watson, C; Tovey, S; Mair, KM; Schiff, R; Natarajan, V; Pyne, NJ; Pyne, S,期刊：Molecular and Cellular Biology, 页码：3827-3841 , 文章类型： Article，,卷期：2010年30-15]
- We demonstrate here a new concept termed "oncogene tolerance" whereby human EGF receptor 2 (HER2) increases sphingosine kinase 1 (SK1) expression in estrogen receptor-positive (ER+) MCF-7 HER2 cells and SK1, in turn, lim...
- Bag1-L Is a Phosphorylation-Dependent Coactivator of c-Jun during Neuronal Apoptosis
[作者：Da Costa, CR; Villadiego, J; Sancho, R; Fontana, X; Packham, G; Nateri, AS; Behrens, A,期刊：Molecular and Cellular Biology, 页码：3842-3852 , 文章类型： Article，,卷期：2010年30-15]
- In the nervous system, cell death by apoptosis plays a critical role during normal development and pathological neurodegeneration. Jun N-terminal kinases (JNKs) are essential regulators of neuronal apoptosis. The AP-1 tr...
- p38 Mitogen-Activated Protein Kinase Promotes Cell Survival in Response to DNA Damage but Is Not Required for the G(2) DNA Damage Checkpoint in Human Cancer Cells
[作者：Phong, MS; Van Horn, RD; Li, SY; Tucker-Kellogg, G; Surana, U; Ye, XS,期刊：Molecular and Cellular Biology, 页码：3816-3826 , 文章类型： Article，,卷期：2010年30-15]
- p38 mitogen-activated protein kinase (MAPK) is rapidly activated by stresses and is believed to play an important role in the stress response. While Chk1 is known to mediate G(2) DNA damage checkpoint control, p38 was al...
- Gfi1 Expression Is Controlled by Five Distinct Regulatory Regions Spread over 100 Kilobases, with Scl/Tal1, Gata2, PU.1, Erg, Meis1, and Runx1 Acting as Upstream Regulators in Early Hematopoietic Cells
[作者：Wilson, NK; Timms, RT; Kinston, SJ; Cheng, YH; Oram, SH; Landry, JR; Mullender, J; Ottersbach, K; Gottgens, B,期刊：Molecular and Cellular Biology, 页码：3853-3863 , 文章类型： Article，,卷期：2010年30-15]
- The growth factor independence 1 (Gfi1) gene was originally discovered in the hematopoietic system, where it functions as a key regulator of stem cell homeostasis, as well as neutrophil and T-cell development. Outside th...
- PAC1 Gene Knockout Reveals an Essential Role of Chaperone-Mediated 20S Proteasome Biogenesis and Latent 20S Proteasomes in Cellular Homeostasis
[作者：Sasaki, K; Hamazaki, J; Koike, M; Hirano, Y; Komatsu, M; Uchiyama, Y; Tanaka, K; Murata, S,期刊：Molecular and Cellular Biology, 页码：3864-3874 , 文章类型： Article，,卷期：2010年30-15]
- The 26S proteasome, a central enzyme for ubiquitin-dependent proteolysis, is a highly complex structure comprising 33 distinct subunits. Recent studies have revealed multiple dedicated chaperones involved in proteasome a...
- HuR Uses AUF1 as a Cofactor To Promote p16(INK4) mRNA Decay
[作者：Chang, N; Yi, J; Guo, GE; Liu, XW; Shang, YF; Tong, TJ; Cui, QH; Zhan, M; Gorospe, M; Wang, WG,期刊：Molecular and Cellular Biology, 页码：3875-3886 , 文章类型： Article，,卷期：2010年30-15]
- In this study, we show that HuR destabilizes p16(INK4) mRNA. Although the knockdown of HuR or AUF1 increased p16 expression, concomitant AUF1 and HuR knockdown had a much weaker effect. The knockdown of Ago2, a component...
- Cks1 Activates Transcription by Binding to the Ubiquitylated Proteasome
[作者：Holic, R; Kukalev, A; Lane, S; Andress, EJ; Lau, I; Yu, CWH; Edelmann, MJ; Kessler, BM; Yu, VPCC,期刊：Molecular and Cellular Biology, 页码：3894-3901 , 文章类型： Article，,卷期：2010年30-15]
- Cyclin-dependent kinase-associated protein 1 (Cks1) is involved in the control of the transcription of a subset of genes in addition to its role in controlling the cell cycle in the budding yeast Saccharomyces cerevisiae...
- Regulation of the Expression and Activity of the Antiangiogenic Homeobox Gene GAX/MEOX2 by ZEB2 and MicroRNA-221
[作者：Chen, Y; Banda, M; Speyer, CL; Smith, JS; Rabson, AB; Gorski, DH,期刊：Molecular and Cellular Biology, 页码：3902-3913 , 文章类型： Article，,卷期：2010年30-15]
- Tumors secrete proangiogenic factors to induce the ingrowth of blood vessels from the stroma. These peptides bind to cell surface receptors on vascular endothelial cells (ECs), triggering signaling cascades that activate...
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