- The CRL4(Cdt2) Ubiquitin Ligase Mediates the Proteolysis of Cyclin-Dependent Kinase Inhibitor Xic1 through a Direct Association with PCNA
[作者：Kim, DH; Budhavarapu, VN; Herrera, CR; Nam, HW; Kim, YS; Yew, PR,期刊：Molecular and Cellular Biology, 页码：4120-4133 , 文章类型： Article，,卷期：2010年30-17]
- During DNA polymerase switching, the Xenopus laevis Cip/Kip-type cyclin-dependent kinase inhibitor Xic1 associates with trimeric proliferating cell nuclear antigen (PCNA) and is recruited to chromatin, where it is ubiqui...
- Myocardin-Related Transcription Factor A Is a Common Mediator of Mechanical Stress- and Neurohumoral Stimulation-Induced Cardiac Hypertrophic Signaling Leading to Activation of Brain Natriuretic Peptide Gene Expression
[作者：Kuwahara, K; Kinoshita, H; Kuwabara, Y; Nakagawa, Y; Usami, S; Minami, T; Yamada, Y; Fujiwara, M; Nakao, K,期刊：Molecular and Cellular Biology, 页码：4134-4148 , 文章类型： Article，,卷期：2010年30-17]
- Subjecting cardiomyocytes to mechanical stress or neurohumoral stimulation causes cardiac hypertrophy characterized in part by reactivation of the fetal cardiac gene program. Here we demonstrate a new common mechanism by...
- Ikaros and Aiolos Inhibit Pre-B-Cell Proliferation by Directly Suppressing c-Myc Expression
[作者：Ma, SB; Pathak, S; Mandal, M; Trinh, L; Clark, MR; Lu, RQ,期刊：Molecular and Cellular Biology, 页码：4149-4158 , 文章类型： Article，,卷期：2010年30-17]
- Pre-B-cell expansion is driven by signals from the interleukin-7 receptor and the pre-B-cell receptor and is dependent on cyclin D3 and c-Myc. We have shown previously that interferon regulatory factors 4 and 8 induce th...
- Opposing Roles of Dnmt1 in Early- and Late-Stage Murine Prostate Cancer
[作者：Kinney, SRM; Moser, MT; Pascual, M; Greally, JM; Foster, BA; Karpf, AR,期刊：Molecular and Cellular Biology, 页码：4159-4174 , 文章类型： Article，,卷期：2010年30-17]
- Previous studies have shown that tumor progression in the transgenic adenocarcinoma of mouse prostate (TRAMP) model is characterized by global DNA hypomethylation initiated during early-stage disease and locus-specific D...
- Sortilin Facilitates Signaling of Ciliary Neurotrophic Factor and Related Helical Type 1 Cytokines Targeting the gp130/Leukemia Inhibitory Factor Receptor beta Heterodimer
[作者：Larsen, JV; Hansen, M; Moller, B; Madsen, P; Scheller, J; Nielsen, M; Petersen, CM,期刊：Molecular and Cellular Biology, 页码：4175-4187 , 文章类型： Article，,卷期：2010年30-17]
- Sortilin is a member of the Vps10p domain family of neuropeptide and neurotrophin binding neuronal receptors. The family members interact with and partly share a variety of ligands and partake in intracellular sorting an...
- Independent and Cooperative Roles of Adaptor Molecules in Proximal Signaling during Fc epsilon RI-Mediated Mast Cell Activation
[作者：Kambayashi, T; Okumura, M; Baker, RG; Hsu, CJ; Baumgart, T; Zhang, WG; Koretzky, GA,期刊：Molecular and Cellular Biology, 页码：4188-4196 , 文章类型： Article，,卷期：2010年30-17]
- Activation through Fc epsilon RI, a high-affinity IgE-binding receptor, is critical for mast cell function during allergy. The formation of a multimolecular proximal signaling complex nucleated by the adaptor molecules S...
- miR-375 Inhibits Differentiation of Neurites by Lowering HuD Levels
[作者：Abdelmohsen, K; Hutchison, ER; Lee, EK; Kuwano, Y; Kim, MM; Masuda, K; Srikantan, S; Subaran, SS; Marasa, BS; Mattson, MP; Gorospe, M,期刊：Molecular and Cellular Biology, 页码：4197-4210 , 文章类型： Article，,卷期：2010年30-17]
- Neuronal development and plasticity are maintained by tightly regulated gene expression programs. Here, we report that the developmentally regulated microRNA miR-375 affects dendrite formation and maintenance. miR-375 ov...
- Cross Talk between Insulin and Bone Morphogenetic Protein Signaling Systems in Brown Adipogenesis
[作者：Zhang, HB; Schulz, TJ; Espinoza, DO; Huang, TL; Emanuelli, B; Kristiansen, K; Tseng, YH,期刊：Molecular and Cellular Biology, 页码：4224-4233 , 文章类型： Article，,卷期：2010年30-17]
- Both insulin and bone morphogenetic protein (BMP) signaling systems are important for adipocyte differentiation. Analysis of gene expression in BMP7-treated fibroblasts revealed a coordinated change in insulin signaling ...
- Islet beta-Cell-Specific MafA Transcription Requires the 5'-Flanking Conserved Region 3 Control Domain
[作者：Raum, JC; Hunter, CS; Artner, I; Henderson, E; Guo, M; Elghazi, L; Sosa-Pineda, B; Ogihara, T; Mirmira, RG; Sussel, L; Stein, R,期刊：Molecular and Cellular Biology, 页码：4234-4244 , 文章类型： Article，,卷期：2010年30-17]
- MafA is a key transcriptional activator of islet beta cells, and its exclusive expression within beta cells of the developing and adult pancreas is distinct among pancreatic regulators. Region 3 ( base pairs -8118 to -77...
- Deficiency in a Glutamine-Specific Methyltransferase for Release Factor Causes Mouse Embryonic Lethality
[作者：Liu, P; Nie, S; Li, B; Yang, ZQ; Xu, ZM; Fei, JA; Lin, CS; Zeng, R; Xu, GL,期刊：Molecular and Cellular Biology, 页码：4245-4253 , 文章类型： Article，,卷期：2010年30-17]
- Biological methylation is a fundamental enzymatic reaction for a variety of substrates in multiple cellular processes. Mammalian N6amt1 was thought to be a homologue of bacterial N-6-adenine DNA methyltransferases, but i...
- Genes of the Ecdysone Biosynthesis Pathway Are Regulated by the dATAC Histone Acetyltransferase Complex in Drosophila
[作者：Pankotai, T; Popescu, C; Martin, D; Grau, B; Zsindely, N; Bodai, L; Tora, L; Ferrus, A; Boros, I,期刊：Molecular and Cellular Biology, 页码：4254-4266 , 文章类型： Article，,卷期：2010年30-17]
- Uncovering mechanisms that regulate ecdysone production is an important step toward understanding the regulation of insect metamorphosis and processes in steroid-related pathologies. We report here the transcriptome anal...
- Protein Tyrosine Kinase 6 Directly Phosphorylates AKT and Promotes AKT Activation in Response to Epidermal Growth Factor
[作者：Zheng, Y; Peng, MY; Wang, ZB; Asara, JM; Tyner, AL,期刊：Molecular and Cellular Biology, 页码：4280-4292 , 文章类型： Article，,卷期：2010年30-17]
- Protein tyrosine kinase 6 (PTK6) is a nonmyristoylated Src-related intracellular tyrosine kinase. Although not expressed in the normal mammary gland, PTK6 is expressed in a majority of human breast tumors examined, and i...
- The Embryonic Transcription Cofactor LBH Is a Direct Target of the Wnt Signaling Pathway in Epithelial Development and in Aggressive Basal Subtype Breast Cancers
[作者：Rieger, ME; Sims, AH; Coats, ER; Clarke, RB; Briegel, KJ,期刊：Molecular and Cellular Biology, 页码：4267-4279 , 文章类型： Article，,卷期：2010年30-17]
- Limb-bud and heart (LBH) is a novel key transcriptional regulator of vertebrate development. However, the molecular mechanisms upstream of LBH and its role in adult development are unknown. Here we show that in epithelia...
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