- Putting the 'HAT' back on survival signalling: the promises and challenges of HDAC inhibition in the treatment of neurological conditions
[作者:Sleiman, SF; Basso, M; Mahishi, L; Kozikowski, AP; Donohoe, ME; Langley, B; Ratan, RR,期刊:Expert opinion on investigational drugs, 页码:573-584 , 文章类型: Review,,卷期:2009年18-5]
- Decreased histone acetyltransferase activity and transcriptional dysfunction have been implicated in almost all neurodegenerative conditions. increasing net histone acetyltransferase activity through inhibition of the hi...
- Synthesis and biological evaluation of novel hydrazide based cytotoxic agents
[作者:Grande, F; Yamada, R; Cao, XF; Aiello, F; Garofalo, A; Neamati, N,期刊:Expert opinion on investigational drugs, 页码:555-568 , 文章类型: Article,,卷期:2009年18-5]
- Recently, we designed and synthesized a series of pyrroloquinoxaline compounds with hydrazine moiety linking a nitrogen-containing polycyclic group to a heteroaroyl system. Several derivatives, with attractive drug-like ...
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