- Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXR alpha
[作者:Kim, K; Kim, KH; Kim, HH; Cheong, J,期刊:Biochemical Journal, 页码:219-230 , 文章类型: Article,,卷期:2008年416-2]
- HBV (hepatitis B virus) is a primary cause of chronic liver disease, which frequently results in hepatitis, cirrhosis and ultimately HCC (hepatocellular carcinoma). Recently, we showed that HBx (HBV protein X) expression...
- The Drosophila dp21-activated kinase Mbt modulates DE-cadherin-mediated cell adhesion by phosphorylation of Armadillo
[作者:Menzel, N; Melzer, J; Waschke, J; Lenz, C; Wecklein, H; Lochnit, G; Drenckhahn, D; Raabe, T,期刊:Biochemical Journal, 页码:231-241 , 文章类型: Article,,卷期:2008年416-2]
- Phosphorylation by tyrosine and serine/threonine kinases regulate the interactions between components of the cadherin-catenin cell-adhesion complex and thus can influence the dynamic modulation of cell adhesion under nor...
- Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions
[作者:Wong, GW; Krawczyk, SA; Kitidis-Mitrokostas, C; Revett, T; Gimeno, R; Lodish, HF,期刊:Biochemical Journal, 页码:161-177 , 文章类型: Article,,卷期:2008年416-2]
- The insulin-sensitizing hormone, adiponectin, belongs to the expanding Clq/TNF (tumour necrosis factor) family of proteins. We recently identified a family of adiponectin paralogues designated as CTRP ((C) under bar lq/(...
- A calmodulin antagonist reveals a calmodulin-independent interdomain interaction essential for activation of inositol 1,4, 5-trisphosphate receptors
[作者:Sun, Y; Taylor, CW,期刊:Biochemical Journal, 页码:243-253 , 文章类型: Article,,卷期:2008年416-2]
- CaM (calmodulin) has been implicated in the regulation Of IP3R [IP3 (inositol 1,4,5-trisphosphate) receptors] and a recent report suggested that CaM tightly tethered to IP3R wits essential for IP3R activation [Nadif Kasr...
- Receptor for advanced glycation end-products (RAGE) modulates neutrophil adhesion and migration on glycoxidated extracellular matrix
[作者:Toure, F; Zahm, JM; Garnotel, R; Lambert, E; Bonnet, N; Schmidt, AM; Vitry, F; Chanard, J; Gillery, P; Rieu, P,期刊:Biochemical Journal, 页码:255-261 , 文章类型: Article,,卷期:2008年416-2]
- AGEs (advanced glycation end-products) accumulate in collagen molecules during uraemia and diabetes, two diseases associated with high susceptibility to bacterial infection. Because neutrophils bind to collagen during th...
- A requirement for thioredoxin in redox-sensitive modulation of T-cadherin expression in endothelial cells
[作者:Joshi, MB; Ivanov, D; Philippow, M; Kyriakakis, E; Erne, P; Resink, TJ,期刊:Biochemical Journal, 页码:271-280 , 文章类型: Article,,卷期:2008年416-2]
- T-cad (T-cadherin), a glycosylphosphatidylinositol-anchored cadherin superfamily member, is expressed widely in the brain and cardiovascular system, and absent, decreased, or even increased, in cancers. Mechanisms contro...
- Mapping of the ATP-binding domain of human fructosamine 3-kinase-related protein by affinity labelling with 5 '-[p-(fluorosulfonyl)benzoyl]adenosine
[作者:Payne, LS; Brown, PM; Middleditch, M; Baker, E; Cooper, GJS; Loomes, KM,期刊:Biochemical Journal, 页码:281-288 , 文章类型: Article,,卷期:2008年416-2]
- fructosamine 3-kinase (Fn3K) fructosamine 3-kinase-related protein (Fn3KRP) glycation
- Carotenoid oxygenases involved in plant branching catalyse a highly specific conserved apocarotenoid cleavage reaction
[作者:Alder, A; Holdermann, I; Beyer, P; Al-Babili, S,期刊:Biochemical Journal, 页码:289-296 , 文章类型: Article,,卷期:2008年416-2]
- Recent studies with the high-tillering mutants in rice (Oryza sativa), the max ((m) under bar ore axillary, growth) mutants in Arabidopsis thaliana and the rins ((r) under bara (m) under bar osu (s) under bar) mutants in...
- Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin
[作者:Cronier, S; Gros, N; Tattum, MH; Jackson, GS; Clarke, AR; Collinge, J; Wadsworth, JDF,期刊:Biochemical Journal, 页码:297-305 , 文章类型: Article,,卷期:2008年416-2]
- Disease-related PrPSc [pathogenic PrP (prion protein)] is classically distinguished from its normal cellular precursor, PrPC(cellular PrP) by its detergent insolubility and partial resistance to proteolysis. Although mol...
- Growth of beta(2)-microglobulin-related amyloid fibrils by non-esterified fatty acids at a neutral pH
[作者:Hasegawa, K; Tsutsumi-Yasuhara, S; Ookoshi, T; Ohhashi, Y; Kimura, H; Takahashi, N; Yoshida, H; Miyazaki, R; Goto, Y; Naiki, H,期刊:Biochemical Journal, 页码:307-315 , 文章类型: Article,,卷期:2008年416-2]
- A beta 2M (beta(2)-microglobulin-related) amyloidosis is a frequent and serious complication in patients on long-term dialysis. Partial unfolding of beta 2-m (beta(2)-microglobulin) may be essential to its assembly into ...
- ER alpha suppresses slug expression directly by transcriptional repression
[作者:Ye, Y; Xiao, Y; Wang, WT; Yearsley, K; Gao, JX; Barsky, SH,期刊:Biochemical Journal, 页码:179-187 , 文章类型: Article,,卷期:2008年416-2]
- Two of the most common signalling pathways in breast cancer are the ER (oestrogen receptor) ligand activation pathway and the E-cadlierin-snail-SlUg-EMT (epithelial-mesenchymal transition) pathway. Although these pathway...
- Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2)
[作者:Schuller, AC; Ahmed, Z; Levitt, JA; Suen, KM; Suhling, K; Ladbury, JE,期刊:Biochemical Journal, 页码:189-199 , 文章类型: Article,,卷期:2008年416-2]
- The adaptor protein She (Src homology and collagen-containing protein) plays an important role in the activation of signalling pathways downstream of RTKs (receptor tyrosine kinases) regulating diverse cellular functions...
- Mutations linked to interstitial lung disease can abrogate anti-amyloid function of prosurfactant protein C
[作者:Nerelius, C; Martin, E; Peng, SW; Gustafsson, M; Nordling, K; Weaver, T; Johansson, J,期刊:Biochemical Journal, 页码:201-209 , 文章类型: Article,,卷期:2008年416-2]
- The newly synthesized proSP-C (surfactant protein C precursor) is an integral ER (endoplasmic reticulum) membrane protein with a single metastable polyvaline a-helical transmembrane domain that comprises two-thirds of th...
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