- The evolving experience with therapeutic TNF inhibition in sepsis: considering the potential influence of risk of death
[作者:Qiu, P; Cui, XZ; Barochia, A; Li, Y; Natanson, C; Eichacker, PQ,期刊:Expert opinion on investigational drugs, 页码:1555-1564 , 文章类型: Review,,卷期:2011年20-11]
- Introduction: Septic shock is highly lethal and its incidence is increasing. Although TNF-alpha plays a key role in sepsis pathogenesis, past efforts to therapeutically inhibit it had limited success. However, there is c...
- Preclinical and clinical activity of the topoisomerase I inhibitor, karenitecin, in melanoma
[作者:Munster, PN; Daud, AI,期刊:Expert opinion on investigational drugs, 页码:1565-1574 , 文章类型: Article,,卷期:2011年20-11]
- Introduction: This review covers the preclinical and clinical activity of the novel camptothecin analog, karenitecin, in melanoma.Areas covered: While the camptothecins are widely used antitumor agents that inhibit topoi...
- Accelerated healing of diabetic wounds by NorLeu(3)-angiotensin (1-7)
[作者:Rodgers, K; Verco, S; Bolton, L; diZerega, G,期刊:Expert opinion on investigational drugs, 页码:1575-1581 , 文章类型: Article,,卷期:2011年20-11]
- Introduction: Diabetes is a disorder that is well known to delay wound repair resulting in the formation of colonized, chronic wounds. The resultant ulcers contribute to increased risk of morbidity, including osteomyelit...
- Dehydroaltenusin is a specific inhibitor of mammalian DNA polymerase alpha
[作者:Mizushina, Y; Maeda, N; Kuriyama, I; Yoshida, H,期刊:Expert opinion on investigational drugs, 页码:1523-1534 , 文章类型: Review,,卷期:2011年20-11]
- Introduction: We carried out a screen for small molecule selective inhibitors of eukaryotic DNA polymerases (pols). Dehydroaltenusin, isolated from a fungus (Alternaria tenuis), was found to be a specific inhibitor of po...
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